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MO-A-213AB-04: Verification of 4D Dose Delivery Using 4D Digital Human Phantom.

Publication ,  Journal Article
Zhang, F; Qin, Y; Segars, W; Yin, F; Cai, J
Published in: Med Phys
June 2012

PURPOSE: At present, techniques of 4D dose verification in radiation therapy for lung cancers associated with respiratory motion are very limited, due to either lack of patient anatomy or breathing information. The aim of this study is to develop a 4D dose verification technique based on XCAT phantom which incorporates both patient anatomy and respiratory mechanics. MATERIALS AND METHODS: The 4D-XCAT phantom which possesses patient specific anatomy and allows input of respiratory parameters was generated using an integrated Matlab program. 10-phase 4DCT, MIP, and AIP images generated from 4D-XCAT were used for designing a 3D conformal treatment plan. Real-time dose delivery was simulated by calculating the deposited dose in each phase of 4D-XCAT for each beam with fixed individual planning dose. The 4D delivered dose was determined by accumulating dose deposition of all beams in all phases using deformable image registration implemented in VelocityAl software. The planned and delivered doses were compared based on target coverage and DVHs of OARs (lungs, cord, heart, and esophagus). RESULTS: Target volume coverage was 97.5% in the simulated real-time delivery, as compared to 95% as planned based on AIP. Maximum cord dose, maximum esophagus dose, mean heart dose, and V20Gy of lung were comparable between the planned and delivered dose; the relative difference were 0.3%, 4.0%, 0%, and 2.8%, respectively. These results indicates AIP-based planning was a close representation of the real 4D dose delivery for both target and OARs when the breathing pattern is regular and reproducible. CONCLUSION: A framework has been successfully established for verifying 4D dose delivery using the 4D-XCAT phantom and deformable image registration. This verification method is capable of incorporating specific patient anatomy and respiratory mechanics.

Duke Scholars

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2012

Volume

39

Issue

6Part20

Start / End Page

3859

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, F., Qin, Y., Segars, W., Yin, F., & Cai, J. (2012). MO-A-213AB-04: Verification of 4D Dose Delivery Using 4D Digital Human Phantom. Med Phys, 39(6Part20), 3859. https://doi.org/10.1118/1.4735756
Zhang, F., Y. Qin, W. Segars, F. Yin, and J. Cai. “MO-A-213AB-04: Verification of 4D Dose Delivery Using 4D Digital Human Phantom.Med Phys 39, no. 6Part20 (June 2012): 3859. https://doi.org/10.1118/1.4735756.
Zhang F, Qin Y, Segars W, Yin F, Cai J. MO-A-213AB-04: Verification of 4D Dose Delivery Using 4D Digital Human Phantom. Med Phys. 2012 Jun;39(6Part20):3859.
Zhang, F., et al. “MO-A-213AB-04: Verification of 4D Dose Delivery Using 4D Digital Human Phantom.Med Phys, vol. 39, no. 6Part20, June 2012, p. 3859. Pubmed, doi:10.1118/1.4735756.
Zhang F, Qin Y, Segars W, Yin F, Cai J. MO-A-213AB-04: Verification of 4D Dose Delivery Using 4D Digital Human Phantom. Med Phys. 2012 Jun;39(6Part20):3859.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2012

Volume

39

Issue

6Part20

Start / End Page

3859

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences