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Estimated tris(1,3-dichloro-2-propyl) phosphate exposure levels for US infants suggest potential health risks.

Publication ,  Journal Article
Hoffman, K; Gearhart-Serna, L; Lorber, M; Webster, TF; Stapleton, HM
Published in: Environmental science & technology letters
August 2017

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been widely used as a flame retardant and is commonly detected in environmental samples. Biomonitoring studies relying on urinary metabolite levels (i.e. bis(1,3-dichloro-2-propyl) phosphate (BDCIPP)) demonstrate widespread exposure, but TDCIPP intake is unknown. Intake data area critical component of meaningful risk assessments and are needed to elucidate the potential health impacts of TDCIPP exposure. Using biomonitoring data, we estimated TDCIPP intake for infants. Infants aged 2-18 months were recruited from central, North Carolina (n=43, recruited 2014-2015), and spot urine samples were analyzed for BDCIPP. TDCIPP intake rates were estimated using daily urine excretion and the fraction of TDCIPP excreted as BDCIPP in urine. Daily TDCIPP intake estimates ranged from 0.01-15.03 μg/kg-day for children included in our assessment, with some variation depending on model assumptions. The U.S. Consumer Products Safety Commission (CPSC) previously established an acceptable daily intake of 5μg/kg-day for non-cancer health risks. Depending on modeling assumptions, we found that 2-9% percent of infants had TDCIPP intake estimates above this threshold. Our results indicate that current TDCIPP exposure levels could pose health risks for highly exposed infants.

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Published In

Environmental science & technology letters

DOI

EISSN

2328-8930

ISSN

2328-8930

Publication Date

August 2017

Volume

4

Issue

8

Start / End Page

334 / 338

Related Subject Headings

  • 4105 Pollution and contamination
  • 4004 Chemical engineering
  • 1002 Environmental Biotechnology
  • 0907 Environmental Engineering
  • 0502 Environmental Science and Management
 

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Hoffman, K., Gearhart-Serna, L., Lorber, M., Webster, T. F., & Stapleton, H. M. (2017). Estimated tris(1,3-dichloro-2-propyl) phosphate exposure levels for US infants suggest potential health risks. Environmental Science & Technology Letters, 4(8), 334–338. https://doi.org/10.1021/acs.estlett.7b00196
Hoffman, Kate, Larisa Gearhart-Serna, Matthew Lorber, Thomas F. Webster, and Heather M. Stapleton. “Estimated tris(1,3-dichloro-2-propyl) phosphate exposure levels for US infants suggest potential health risks.Environmental Science & Technology Letters 4, no. 8 (August 2017): 334–38. https://doi.org/10.1021/acs.estlett.7b00196.
Hoffman K, Gearhart-Serna L, Lorber M, Webster TF, Stapleton HM. Estimated tris(1,3-dichloro-2-propyl) phosphate exposure levels for US infants suggest potential health risks. Environmental science & technology letters. 2017 Aug;4(8):334–8.
Hoffman, Kate, et al. “Estimated tris(1,3-dichloro-2-propyl) phosphate exposure levels for US infants suggest potential health risks.Environmental Science & Technology Letters, vol. 4, no. 8, Aug. 2017, pp. 334–38. Epmc, doi:10.1021/acs.estlett.7b00196.
Hoffman K, Gearhart-Serna L, Lorber M, Webster TF, Stapleton HM. Estimated tris(1,3-dichloro-2-propyl) phosphate exposure levels for US infants suggest potential health risks. Environmental science & technology letters. 2017 Aug;4(8):334–338.
Journal cover image

Published In

Environmental science & technology letters

DOI

EISSN

2328-8930

ISSN

2328-8930

Publication Date

August 2017

Volume

4

Issue

8

Start / End Page

334 / 338

Related Subject Headings

  • 4105 Pollution and contamination
  • 4004 Chemical engineering
  • 1002 Environmental Biotechnology
  • 0907 Environmental Engineering
  • 0502 Environmental Science and Management