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Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis.

Publication ,  Journal Article
Robertson, SH; Virgincar, RS; Bier, EA; He, M; Schrank, GM; Smigla, RM; Rackley, C; McAdams, HP; Driehuys, B
Published in: Magn Reson Med
October 2017

PURPOSE: The purpose of this work was to accurately characterize the spectral properties of hyperpolarized 129 Xe in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers. METHODS: Subjects underwent hyperpolarized 129 Xe breath-hold spectroscopy, during which 38 dissolved-phase free induction decays (FIDs) were acquired after reaching steady state (echo time/repetition time = 0.875/50 ms; bandwidth = 8.06 kHz; flip angle≈22 °). FIDs were averaged and then decomposed into multiple spectral components using time-domain curve fitting. The resulting amplitudes, frequencies, line widths, and starting phases of each component were compared among groups using a Mann-Whitney-Wilcoxon U test. RESULTS: Three dissolved-phase resonances, consisting of red blood cells (RBCs) and two barrier compartments, were consistently identified in all subjects. In subjects with IPF relative to healthy volunteers, the RBC frequency was 0.70 parts per million (ppm) more negative (P = 0.05), the chemical shift of barrier 2 was 0.6 ppm more negative (P = 0.009), the line widths of both barrier peaks were ∼2 ppm narrower (P < 0.001), and the starting phase of barrier 1 was 20.3 ° higher (P =  0.01). Moreover, the ratio RBC:barriers was reduced by 52.9% in IPF (P < 0.001). CONCLUSIONS: The accurate decomposition of 129 Xe spectra not only has merit for developing a global metric of pulmonary function, but also provides necessary insights to optimize phase-sensitive methods for imaging 129 Xe gas transfer. Magn Reson Med 78:1306-1315, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

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Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

October 2017

Volume

78

Issue

4

Start / End Page

1306 / 1315

Location

United States

Related Subject Headings

  • Young Adult
  • Xenon Isotopes
  • Signal Processing, Computer-Assisted
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Idiopathic Pulmonary Fibrosis
  • Humans
 

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Robertson, S. H., Virgincar, R. S., Bier, E. A., He, M., Schrank, G. M., Smigla, R. M., … Driehuys, B. (2017). Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis. Magn Reson Med, 78(4), 1306–1315. https://doi.org/10.1002/mrm.26533
Robertson, Scott H., Rohan S. Virgincar, Elianna A. Bier, Mu He, Geoffrey M. Schrank, Rose Marie Smigla, Craig Rackley, H Page McAdams, and Bastiaan Driehuys. “Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis.Magn Reson Med 78, no. 4 (October 2017): 1306–15. https://doi.org/10.1002/mrm.26533.
Robertson, Scott H., et al. “Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis.Magn Reson Med, vol. 78, no. 4, Oct. 2017, pp. 1306–15. Pubmed, doi:10.1002/mrm.26533.
Robertson SH, Virgincar RS, Bier EA, He M, Schrank GM, Smigla RM, Rackley C, McAdams HP, Driehuys B. Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis. Magn Reson Med. 2017 Oct;78(4):1306–1315.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

October 2017

Volume

78

Issue

4

Start / End Page

1306 / 1315

Location

United States

Related Subject Headings

  • Young Adult
  • Xenon Isotopes
  • Signal Processing, Computer-Assisted
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Idiopathic Pulmonary Fibrosis
  • Humans