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Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology.

Publication ,  Journal Article
Qian, R; Carrasco-Zevallos, OM; Mangalesh, S; Sarin, N; Vajzovic, L; Farsiu, S; Izatt, JA; Toth, CA
Published in: Transl Vis Sci Technol
October 2017

PURPOSE: We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. METHODS: A prototype swept source OCT system with a LWD (defined as distance from the last optical element of the imaging system to the eye) of 350 mm with custom fixation targets was developed to facilitate imaging of children. Imaging was performed in 49 participants from three age groups: 26 adults, 16 children 13 to 18 years old (teenagers), and seven children under 6 years old (young children) under an approved institutional review board protocol. The imaging goal was to acquire high quality scans of the fovea and optic nerve in each eye in the shortest time possible. OCT B-scans and volumes of the fovea and optic nerve head of each eligible eye were captured and graded based on four categories (lateral and axial centration, contrast, and resolution) and on ability to determine presence or absence of pathology. RESULTS: LWD-OCT imaging was successful in 88 of 94 eligible eyes, including seven of 10 eyes of young children. Of the successfully acquired OCT images, 83% of B-scan and volumetric images, including 86% from young children, were graded as high-quality scans. Pathology was observed in high-quality OCT images. CONCLUSIONS: The prototype LWD-OCT system achieved high quality retinal imaging of adults, teenagers, and some young children with and without pathology with reasonable alignment time. TRANSLATIONAL RELEVANCE: The LWD-OCT system can facilitate imaging in children.

Duke Scholars

Published In

Transl Vis Sci Technol

DOI

ISSN

2164-2591

Publication Date

October 2017

Volume

6

Issue

5

Start / End Page

12

Location

United States

Related Subject Headings

  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
  • 0903 Biomedical Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Qian, R., Carrasco-Zevallos, O. M., Mangalesh, S., Sarin, N., Vajzovic, L., Farsiu, S., … Toth, C. A. (2017). Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology. Transl Vis Sci Technol, 6(5), 12. https://doi.org/10.1167/tvst.6.5.12
Qian, Ruobing, Oscar M. Carrasco-Zevallos, Shwetha Mangalesh, Neeru Sarin, Lejla Vajzovic, Sina Farsiu, Joseph A. Izatt, and Cynthia A. Toth. “Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology.Transl Vis Sci Technol 6, no. 5 (October 2017): 12. https://doi.org/10.1167/tvst.6.5.12.
Qian R, Carrasco-Zevallos OM, Mangalesh S, Sarin N, Vajzovic L, Farsiu S, et al. Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology. Transl Vis Sci Technol. 2017 Oct;6(5):12.
Qian, Ruobing, et al. “Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology.Transl Vis Sci Technol, vol. 6, no. 5, Oct. 2017, p. 12. Pubmed, doi:10.1167/tvst.6.5.12.
Qian R, Carrasco-Zevallos OM, Mangalesh S, Sarin N, Vajzovic L, Farsiu S, Izatt JA, Toth CA. Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology. Transl Vis Sci Technol. 2017 Oct;6(5):12.

Published In

Transl Vis Sci Technol

DOI

ISSN

2164-2591

Publication Date

October 2017

Volume

6

Issue

5

Start / End Page

12

Location

United States

Related Subject Headings

  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
  • 0903 Biomedical Engineering