Scholars@Duke publication: S-nitrosothiols in lung inflammation

Therapeutic Targets in Airway Inflammation

S-nitrosothiols in lung inflammation

Publication , Chapter

Marshall, HE; Que, LG; Stamler, JS; Gaston, B

January 1, 2003

S-Nitrosothiols (SNOs) are complexes of nitric oxide (NO) bound to thiol groups, which are present in biological systems as proteins and low molecular weight peptides (1,2). SNOs have been regarded by some as markers of NO production [i.e., nitric oxide synthase (NOS) activity] with little inherent bioactivity. However, it has now become apparent that SNOs are critical mediators involved in several cellsignaling pathways. For example, S-nitrosylation reactions (i.e., reactions forming S-NO bonds) are involved in the regulation of p21ras (3) the ryanodine receptor (4), the N-methyl-D-aspartate (NMDA) receptor (5), caspase 3 activity (6,7), and NF-B (p50-p65) (8). In addition, SNOs function physiologically in controlling ventilation (5) and O2 delivery (9).

Duke Scholars

Author Harvey Edwin Marshall III Medicine, Pulmonary, Allergy, and Critical Care Medicine

Author Loretta Georgina Que Medicine, Pulmonary, Allergy, and Critical Care Medicine

ISBN

9780824709563

Publication Date

January 1, 2003

Start / End Page

123 / 142

Citation

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Marshall, H. E., Que, L. G., Stamler, J. S., & Gaston, B. (2003). S-nitrosothiols in lung inflammation. In Therapeutic Targets in Airway Inflammation (pp. 123–142).

Marshall, H. E., L. G. Que, J. S. Stamler, and B. Gaston. “S-nitrosothiols in lung inflammation.” In Therapeutic Targets in Airway Inflammation, 123–42, 2003.

Marshall HE, Que LG, Stamler JS, Gaston B. S-nitrosothiols in lung inflammation. In: Therapeutic Targets in Airway Inflammation. 2003. p. 123–42.

Marshall, H. E., et al. “S-nitrosothiols in lung inflammation.” Therapeutic Targets in Airway Inflammation, 2003, pp. 123–42.

Marshall HE, Que LG, Stamler JS, Gaston B. S-nitrosothiols in lung inflammation. Therapeutic Targets in Airway Inflammation. 2003. p. 123–142.

ISBN

9780824709563

Publication Date

January 1, 2003

Start / End Page

123 / 142