Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University 1995 - 1998
  • Chief Medical Resident, Medicine, University of Alabama Birmingham 1994 - 1995
  • Medical Resident, Medicine, University of Alabama Birmingham 1991 - 1994
  • M.D., Wake Forest University 1991
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2011 - 2020
  • Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2010 - 2011
  • Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2001 - 2010
  • Associate in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1998 - 2001
  • Instructor, Temporary in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1998
• Research
• 

  Selected Grants

  • Role of S-nitrosothiols on Akt1 signaling and pneumonia resolution awarded by National Institutes of Health 2017 - 2021
  • Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2021
  • S-nitrosothiols, NF-KappaB and Inflammation in Acute Lung Injury awarded by National Institutes of Health 2014 - 2019
  • S-nitrosothiol-regulated pathways in acute lung injury awarded by National Institutes of Health 2010 - 2013
  • Regulation of NF-Kappa B by nitric oxide in the lung awarded by National Institutes of Health 2000 - 2006
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Kelleher, Zachary T., Chunbo Wang, Michael T. Forrester, Matthew W. Foster, and Harvey E. Marshall. “ERK-dependent proteasome degradation of Txnip regulates thioredoxin oxidoreductase activity.” J Biol Chem 294, no. 36 (September 6, 2019): 13336–43. https://doi.org/10.1074/jbc.RA119.007733.
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    • Mehta, K., E. J. Soderblom, J. W. Thompson, L. G. Que, H. E. Marshall, M. A. Moseley, and M. W. Foster. “Targeted proteomics for unraveling the post-translational regulation of human nitric oxide synthase 2.” Nitric Oxide 42C (November 15, 2014): 132. https://doi.org/10.1016/j.niox.2014.09.100.
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    • Kelleher, Zachary T., Yonggang Sha, Matthew W. Foster, W Michael Foster, Michael T. Forrester, and Harvey E. Marshall. “Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor κB (NF-κB) activation.” J Biol Chem 289, no. 5 (January 31, 2014): 3066–72. https://doi.org/10.1074/jbc.M113.503938.
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    • Foster, Matthew W., J Will Thompson, Michael T. Forrester, Yonggang Sha, Timothy J. McMahon, Dawn E. Bowles, M Arthur Moseley, and Harvey E. Marshall. “Proteomic analysis of the NOS2 interactome in human airway epithelial cells.” Nitric Oxide 34 (November 1, 2013): 37–46. https://doi.org/10.1016/j.niox.2013.02.079.
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    • Foster, Matthew W., J Will Thompson, Loretta G. Que, Ivana V. Yang, David A. Schwartz, M Arthur Moseley, and Harvey E. Marshall. “Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure.” J Proteome Res 12, no. 5 (May 3, 2013): 2194–2205. https://doi.org/10.1021/pr400066g.
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    • Foster, M. W., J. W. Thompson, L. G. Que, I. V. Yang, D. A. Schwartz, M. A. Moseley, and H. E. Marshall. “Proteomic Analysis Of Human Bronchoalveolar Lavage Fluid After Subsegmental Challenge.” American Journal of Respiratory and Critical Care Medicine 187 (2013).
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    • Marshall, Harvey E., and Matthew W. Foster. “S-nitrosylation of Ras in breast cancer.” Breast Cancer Res 14, no. 6 (November 12, 2012): 113. https://doi.org/10.1186/bcr3331.
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    • Marshall, Harvey E., and Andrew Gow. “Regulation of cellular processes by S-nitrosylation. Preface.” Biochim Biophys Acta 1820, no. 6 (June 2012): 673–74. https://doi.org/10.1016/j.bbagen.2012.04.007.
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    • Sha, Yonggang, and Harvey E. Marshall. “S-nitrosylation in the regulation of gene transcription.” Biochim Biophys Acta 1820, no. 6 (June 2012): 701–11. https://doi.org/10.1016/j.bbagen.2011.05.008.
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    • Yang, Ivana V., John Tomfohr, Jaspal Singh, Catherine M. Foss, Harvey E. Marshall, Loretta G. Que, Erin McElvania-Tekippe, Sarita Florence, John S. Sundy, and David A. Schwartz. “The clinical and environmental determinants of airway transcriptional profiles in allergic asthma.” Am J Respir Crit Care Med 185, no. 6 (March 15, 2012): 620–27. https://doi.org/10.1164/rccm.201108-1503OC.
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    • Kelleher, Zachary T., Erin N. Potts, Mulugu V. Brahmajothi, Matthew W. Foster, Richard L. Auten, W Michael Foster, and Harvey E. Marshall. “NOS2 regulation of LPS-induced airway inflammation via S-nitrosylation of NF-{kappa}B p65.” Am J Physiol Lung Cell Mol Physiol 301, no. 3 (September 2011): L327–33. https://doi.org/10.1152/ajplung.00463.2010.
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    • Forrester, Michael T., Divya Seth, Alfred Hausladen, Christine E. Eyler, Matthew W. Foster, Akio Matsumoto, Moran Benhar, Harvey E. Marshall, and Jonathan S. Stamler. “Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation.” J Biol Chem 284, no. 52 (December 25, 2009): 36160–66. https://doi.org/10.1074/jbc.M109.057729.
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    • Marshall, Harvey E., Erin N. Potts, Zachary T. Kelleher, Jonathan S. Stamler, W Michael Foster, and Richard L. Auten. “Protection from lipopolysaccharide-induced lung injury by augmentation of airway S-nitrosothiols.” Am J Respir Crit Care Med 180, no. 1 (July 1, 2009): 11–18. https://doi.org/10.1164/rccm.200807-1186OC.
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    • Kelleher, Zachary T., Akio Matsumoto, Jonathan S. Stamler, and Harvey E. Marshall. “NOS2 regulation of NF-kappaB by S-nitrosylation of p65.” J Biol Chem 282, no. 42 (October 19, 2007): 30667–72. https://doi.org/10.1074/jbc.M705929200.
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    • Hess, Douglas T., Akio Matsumoto, Sung-Oog Kim, Harvey E. Marshall, and Jonathan S. Stamler. “Protein S-nitrosylation: purview and parameters.” Nat Rev Mol Cell Biol 6, no. 2 (February 2005): 150–66. https://doi.org/10.1038/nrm1569.
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    • Marshall, Harvey E., Douglas T. Hess, and Jonathan S. Stamler. “S-nitrosylation: physiological regulation of NF-kappaB.” Proc Natl Acad Sci U S A 101, no. 24 (June 15, 2004): 8841–42. https://doi.org/10.1073/pnas.0403034101.
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    • Liu, Limin, Yun Yan, Ming Zeng, Jian Zhang, Martha A. Hanes, Gregory Ahearn, Timothy J. McMahon, et al. “Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.” Cell 116, no. 4 (February 20, 2004): 617–28. https://doi.org/10.1016/s0092-8674(04)00131-x.
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    • Marshall, Harvey E., and Jonathan S. Stamler. “Nitrosative stress-induced apoptosis through inhibition of NF-kappa B.” J Biol Chem 277, no. 37 (September 13, 2002): 34223–28. https://doi.org/10.1074/jbc.M201638200.
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    • Marshall, H. E., and J. S. Stamler. “Inhibition of NF-kappa B by S-nitrosylation.” Biochemistry 40, no. 6 (February 13, 2001): 1688–93. https://doi.org/10.1021/bi002239y.
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    • Marshall, H. E., K. Merchant, and J. S. Stamler. “Nitrosation and oxidation in the regulation of gene expression.” Faseb J 14, no. 13 (October 2000): 1889–1900. https://doi.org/10.1096/fj.00.011rev.
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    • Marshall, H. E., and J. S. Stamler. “NO waiting to exhale in asthma.” Am J Respir Crit Care Med 161, no. 3 Pt 1 (March 2000): 685–87. https://doi.org/10.1164/ajrccm.161.3.16134.
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    • Marshall, H. E., and J. S. Stamler. “Exhaled nitric oxide (NO), NO synthase activity, and regulation of nuclear factor (NF)-kappaB.” Am J Respir Cell Mol Biol 21, no. 3 (September 1999): 296–97. https://doi.org/10.1165/ajrcmb.21.3.f164.
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    • Marshall, H. E., K. P. Keenan, and E. M. McDowell. “The stathmokinetic and morphological response of the hamster respiratory epithelium to intralaryngeal instillations of saline and ferric oxide in saline.” Fundam Appl Toxicol 9, no. 4 (November 1987): 705–14. https://doi.org/10.1016/0272-0590(87)90177-1.
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    • III, H. E. M., K. P. Keenan, and E. M. McDowell. “The stathmokinetic and morphological response of the hamster respiratory epithelium to intralaryngeal instillations of saline and ferric oxide in saline.” Fundamental and Applied Toxicology 9, no. 4 (1987): 705–14.

  • Book Sections

    • Marshall, H. E., L. G. Que, J. S. Stamler, and B. Gaston. “S-nitrosothiols in lung inflammation.” In Therapeutic Targets in Airway Inflammation, 123–42, 2003.

  • Conference Papers

    • Foster, M. W., Z. T. Kelleher, M. T. Forrester, D. E. Bowles, M. A. Moseley, and H. E. Marshall. “Quantitative Proteomics Of The Cytokine-Modulated Nos2 Interactome In Airway Epithelium.” In American Journal of Respiratory and Critical Care Medicine, Vol. 183. AMER THORACIC SOC, 2011.
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• Teaching & Mentoring
• 

  Recent Courses

  • MEDICINE 430C: Pulmonary Medicine 2021
  • MEDICINE 430C: Pulmonary Medicine 2020
  • MEDICINE 430C: Pulmonary Medicine 2019

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