Conceptual and technical approaches to human neural ensemble recordings
The ability to perform either multineuron or local field/EEG recordings from the nervous system is a critical requirement to develop a new generation of neuroprosthetics that can sense the brain’s intent for action (Nicolelis 2001, 2003). This form of sensing neuroprosthesis builds upon the concept of current neuroprosthetic devices, which are primarily for macrostimulation of neural elements, such as deep brain stimulation (DBS); (Abosch, Hutchison et al. 2002; Rodriguez-Oroz, Obeso et al. 2005). A key aspect of this evolving technology is the translation of preclinical multineuron recording and analysis technology into the clinical arena (Donoghue 2002; Carmena, Lebedev et al. 2003; Mussa-Ivaldi, Miller et al. 2003). This translation requires the use of medical-grade components at all levels of electrodes, connections, and electronics, and the stabilization of technology and software for the long process of Food and Drug Administration (FDA) approval.
