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Application of long-interval paired-pulse transcranial magnetic stimulation to motion-sensitive visual cortex does not lead to changes in motion discrimination.

Publication ,  Journal Article
Gamboa, OL; Brito, A; Abzug, Z; D'Arbeloff, T; Beynel, L; Wing, EA; Dannhauer, M; Palmer, H; Hilbig, SA; Crowell, CA; Liu, S; Donaldson, R ...
Published in: Neurosci Lett
June 21, 2020

The perception of visual motion is dependent on a set of occipitotemporal regions that are readily accessible to neuromodulation. The current study tested if paired-pulse Transcranial Magnetic Stimulation (ppTMS) could modulate motion perception by stimulating the occipital cortex as participants viewed near-threshold motion dot stimuli. In this sham-controlled study, fifteen subjects completed two sessions. On the first visit, resting motor threshold (RMT) was assessed, and participants performed an adaptive direction discrimination task to determine individual motion sensitivity. During the second visit, subjects performed the task with three difficulty levels as TMS pulses were delivered 150 and 50 ms prior to motion stimulus onset at 120% RMT, under the logic that the cumulative inhibitory effect of these pulses would alter motion sensitivity. ppTMS was delivered at one of two locations: 3 cm dorsal and 5 cm lateral to inion (scalp-based coordinate), or at the site of peak activation for "motion" according to the NeuroSynth fMRI database (meta-analytic coordinate). Sham stimulation was delivered on one-third of trials by tilting the coil 90°. Analyses showed no significant active-versus-sham effects of ppTMS when stimulation was delivered to the meta-analytic (p = 0.15) or scalp-based coordinates (p = 0.17), which were separated by 29 mm on average. Active-versus-sham stimulation differences did not interact with either stimulation location (p = 0.12) or difficulty (p = 0.33). These findings fail to support the hypothesis that long-interval ppTMS recruits inhibitory processes in motion-sensitive cortex but must be considered within the limited parameters used in this design.

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Published In

Neurosci Lett

DOI

EISSN

1872-7972

Publication Date

June 21, 2020

Volume

730

Start / End Page

135022

Location

Ireland

Related Subject Headings

  • Visual Cortex
  • Transcranial Magnetic Stimulation
  • Rest
  • Occipital Lobe
  • Neural Inhibition
  • Motor Cortex
  • Motion Perception
  • Male
  • Humans
  • Female
 

Citation

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Gamboa, O. L., Brito, A., Abzug, Z., D’Arbeloff, T., Beynel, L., Wing, E. A., … Appelbaum, L. G. (2020). Application of long-interval paired-pulse transcranial magnetic stimulation to motion-sensitive visual cortex does not lead to changes in motion discrimination. Neurosci Lett, 730, 135022. https://doi.org/10.1016/j.neulet.2020.135022
Gamboa, Olga Lucia, Alexandra Brito, Zachary Abzug, Tracy D’Arbeloff, Lysianne Beynel, Erik A. Wing, Moritz Dannhauer, et al. “Application of long-interval paired-pulse transcranial magnetic stimulation to motion-sensitive visual cortex does not lead to changes in motion discrimination.Neurosci Lett 730 (June 21, 2020): 135022. https://doi.org/10.1016/j.neulet.2020.135022.
Gamboa OL, Brito A, Abzug Z, D’Arbeloff T, Beynel L, Wing EA, et al. Application of long-interval paired-pulse transcranial magnetic stimulation to motion-sensitive visual cortex does not lead to changes in motion discrimination. Neurosci Lett. 2020 Jun 21;730:135022.
Gamboa, Olga Lucia, et al. “Application of long-interval paired-pulse transcranial magnetic stimulation to motion-sensitive visual cortex does not lead to changes in motion discrimination.Neurosci Lett, vol. 730, June 2020, p. 135022. Pubmed, doi:10.1016/j.neulet.2020.135022.
Gamboa OL, Brito A, Abzug Z, D’Arbeloff T, Beynel L, Wing EA, Dannhauer M, Palmer H, Hilbig SA, Crowell CA, Liu S, Donaldson R, Cabeza R, Davis SW, Peterchev AV, Sommer MA, Appelbaum LG. Application of long-interval paired-pulse transcranial magnetic stimulation to motion-sensitive visual cortex does not lead to changes in motion discrimination. Neurosci Lett. 2020 Jun 21;730:135022.
Journal cover image

Published In

Neurosci Lett

DOI

EISSN

1872-7972

Publication Date

June 21, 2020

Volume

730

Start / End Page

135022

Location

Ireland

Related Subject Headings

  • Visual Cortex
  • Transcranial Magnetic Stimulation
  • Rest
  • Occipital Lobe
  • Neural Inhibition
  • Motor Cortex
  • Motion Perception
  • Male
  • Humans
  • Female