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Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure.

Publication ,  Journal Article
He, L; Cui, X; Li, Z; Teng, Y; Barkjohn, KK; Norris, C; Fang, L; Lin, L; Wang, Q; Zhou, X; Hong, J; Li, F; Zhang, Y; Schauer, JJ; Black, M ...
Published in: Environmental science & technology
September 2020

Fine particulate matter (PM2.5) and ozone (O3) may exert oxidative damage in the nose, which is hypothesized to be associated with worsened asthma symptoms. This study, hence, is to explore whether an oxidative stress biomarker, malondialdehyde (MDA) in the nasal fluid, has the potential to aid personalized asthma control. In a panel study of 43 asthmatic children, 5-13 years old, each child was measured 4 times with a 2-week interval between consecutive clinic visits. At each visit, nasal fluid and urine samples were collected, and fractional exhaled nitric oxide (FeNO) was measured as a biomarker of pulmonary inflammation. In addition to nasal MDA, urinary MDA and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured as biomarkers of systemic oxidative stress. We also assessed asthma symptoms using the Childhood Asthma-Control Test (C-ACT). We found that interquartile range (IQR) increases in 24 h average personal PM2.5 exposure (22.2-33.5 μg/m3), estimated 0 to 5 days prior to a clinic visit, were associated with increased nasal MDA concentrations by 38.6-54.9%. Similarly, IQR increases in 24 h average personal O3 exposure (7.7-8.2 ppb) estimated 2 to 4 days prior were associated with increased nasal MDA by 22.1-69.4%. Only increased PM2.5 exposure was associated with increased FeNO. Increased nasal MDA concentration was associated with decreased total and individual C-ACT scores, indicating worsening of asthma symptoms. However, no significant associations were observed between urinary MDA or 8-OHdG and C-ACT scores. The results confirm that oxidative stress plays an important role in linking air pollution exposure and adverse respiratory health effects. These findings support that MDA in the nasal fluid may serve as a useful biomarker for monitoring asthma status, especially in relation to PM2.5 and O3 exposures, two known risk factors of asthma exacerbation.

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Published In

Environmental science & technology

DOI

EISSN

1520-5851

ISSN

0013-936X

Publication Date

September 2020

Volume

54

Issue

18

Start / End Page

11405 / 11413

Related Subject Headings

  • Particulate Matter
  • Malondialdehyde
  • Humans
  • Environmental Sciences
  • Environmental Exposure
  • Child, Preschool
  • Child
  • Biomarkers
  • Asthma
  • Air Pollution
 

Citation

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ICMJE
MLA
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He, L., Cui, X., Li, Z., Teng, Y., Barkjohn, K. K., Norris, C., … Zhang, J. J. (2020). Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure. Environmental Science & Technology, 54(18), 11405–11413. https://doi.org/10.1021/acs.est.0c02558
He, Linchen, Xiaoxing Cui, Zhen Li, Yanbo Teng, Karoline K. Barkjohn, Christina Norris, Lin Fang, et al. “Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure.Environmental Science & Technology 54, no. 18 (September 2020): 11405–13. https://doi.org/10.1021/acs.est.0c02558.
He L, Cui X, Li Z, Teng Y, Barkjohn KK, Norris C, et al. Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure. Environmental science & technology. 2020 Sep;54(18):11405–13.
He, Linchen, et al. “Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure.Environmental Science & Technology, vol. 54, no. 18, Sept. 2020, pp. 11405–13. Epmc, doi:10.1021/acs.est.0c02558.
He L, Cui X, Li Z, Teng Y, Barkjohn KK, Norris C, Fang L, Lin L, Wang Q, Zhou X, Hong J, Li F, Zhang Y, Schauer JJ, Black M, Bergin MH, Zhang JJ. Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure. Environmental science & technology. 2020 Sep;54(18):11405–11413.
Journal cover image

Published In

Environmental science & technology

DOI

EISSN

1520-5851

ISSN

0013-936X

Publication Date

September 2020

Volume

54

Issue

18

Start / End Page

11405 / 11413

Related Subject Headings

  • Particulate Matter
  • Malondialdehyde
  • Humans
  • Environmental Sciences
  • Environmental Exposure
  • Child, Preschool
  • Child
  • Biomarkers
  • Asthma
  • Air Pollution