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Impact of Using Uniform Attenuation Coefficients for Heterogeneously Dense Breasts in a Dedicated Breast PET/X-ray Scanner.

Publication ,  Journal Article
MacDonald, LR; Lo, JY; Sturgeon, GM; Zeng, C; Harrison, RL; Kinahan, PE; Segars, WP
Published in: IEEE Trans Radiat Plasma Med Sci
September 2020

We investigated PET image quantification when using a uniform attenuation coefficient (μ) for attenuation correction (AC) of anthropomorphic density phantoms derived from high-resolution breast CT scans. A breast PET system was modeled with perfect data corrections except for AC. Using uniform μ for AC resulted in quantitative errors roughly proportional to the difference between μ used in AC (μ AC) and local μ, yielding approximately ± 5% bias, corresponding to the variation of μ for 511 keV photons in breast tissue. Global bias was lowest when uniform μ AC was equal to the phantom mean μ (μ mean). Local bias in 10-mm spheres increased as the sphere μ deviated from μ mean, but remained only 2-3% when the μ sphere was 6.5% higher than μ mean. Bias varied linearly with and was roughly proportional to local μ mismatch. Minimizing local bias, e.g., in a small sphere, required the use of a uniform μ value between the local μ and the μ mean. Thus, biases from using uniform-μ AC are low when local μ sphere is close to μ mean. As the μ sphere increasingly differs from the phantom μ mean, bias increases, and the optimal uniform μ is less predictable, having a value between μ sphere and the phantom μ mean.

Duke Scholars

Published In

IEEE Trans Radiat Plasma Med Sci

DOI

ISSN

2469-7311

Publication Date

September 2020

Volume

4

Issue

5

Start / End Page

585 / 593

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
MacDonald, L. R., Lo, J. Y., Sturgeon, G. M., Zeng, C., Harrison, R. L., Kinahan, P. E., & Segars, W. P. (2020). Impact of Using Uniform Attenuation Coefficients for Heterogeneously Dense Breasts in a Dedicated Breast PET/X-ray Scanner. IEEE Trans Radiat Plasma Med Sci, 4(5), 585–593. https://doi.org/10.1109/trpms.2020.2991120
MacDonald, Lawrence R., Joseph Y. Lo, Gregory M. Sturgeon, Chengeng Zeng, Robert L. Harrison, Paul E. Kinahan, and William Paul Segars. “Impact of Using Uniform Attenuation Coefficients for Heterogeneously Dense Breasts in a Dedicated Breast PET/X-ray Scanner.IEEE Trans Radiat Plasma Med Sci 4, no. 5 (September 2020): 585–93. https://doi.org/10.1109/trpms.2020.2991120.
MacDonald LR, Lo JY, Sturgeon GM, Zeng C, Harrison RL, Kinahan PE, et al. Impact of Using Uniform Attenuation Coefficients for Heterogeneously Dense Breasts in a Dedicated Breast PET/X-ray Scanner. IEEE Trans Radiat Plasma Med Sci. 2020 Sep;4(5):585–93.
MacDonald, Lawrence R., et al. “Impact of Using Uniform Attenuation Coefficients for Heterogeneously Dense Breasts in a Dedicated Breast PET/X-ray Scanner.IEEE Trans Radiat Plasma Med Sci, vol. 4, no. 5, Sept. 2020, pp. 585–93. Pubmed, doi:10.1109/trpms.2020.2991120.
MacDonald LR, Lo JY, Sturgeon GM, Zeng C, Harrison RL, Kinahan PE, Segars WP. Impact of Using Uniform Attenuation Coefficients for Heterogeneously Dense Breasts in a Dedicated Breast PET/X-ray Scanner. IEEE Trans Radiat Plasma Med Sci. 2020 Sep;4(5):585–593.

Published In

IEEE Trans Radiat Plasma Med Sci

DOI

ISSN

2469-7311

Publication Date

September 2020

Volume

4

Issue

5

Start / End Page

585 / 593

Location

United States