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Novel Acoustic Biomarker of Quality of Life in Left Ventricular Assist Device Recipients.

Publication ,  Journal Article
Mainsah, BO; Patel, PA; Chen, XJ; Olsen, C; Collins, LM; Karra, R
Published in: J Am Heart Assoc
March 16, 2021

Background Although technological advances to pump design have improved survival, left ventricular assist device (LVAD) recipients experience variable improvements in quality of life. Methods for optimizing LVAD support to improve quality of life are needed. We investigated whether acoustic signatures obtained from digital stethoscopes can predict patient-centered outcomes in LVAD recipients. Methods and Results We followed precordial sounds over 6 months in 24 LVAD recipients (8 HeartWare HVAD™, 16 HeartMate 3 [HM3]). Subjects recorded their precordial sounds with a digital stethoscope and completed a Kansas City Cardiomyopathy Questionnaire weekly. We developed a novel algorithm to filter LVAD sounds from recordings. Unsupervised clustering of LVAD-mitigated sounds revealed distinct groups of acoustic features. Of 16 HM3 recipients, 6 (38%) had a unique acoustic feature that we have termed the pulse synchronized sound based on its temporal association with the artificial pulse of the HM3. HM3 recipients with the pulse synchronized sound had significantly better Kansas City Cardiomyopathy Questionnaire scores at baseline (median, 89.1 [interquartile range, 86.2-90.4] versus 66.1 [interquartile range, 31.1-73.7]; P=0.03) and over the 6-month study period (marginal mean, 77.6 [95% CI, 66.3-88.9] versus 59.9 [95% CI, 47.9-70.0]; P<0.001). Mechanistically, the pulse synchronized sound shares acoustic features with patient-derived intrinsic sounds. Finally, we developed a machine learning algorithm to automatically detect the pulse synchronized sound within precordial sounds (area under the curve, 0.95, leave-one-subject-out cross-validation). Conclusions We have identified a novel acoustic biomarker associated with better quality of life in HM3 LVAD recipients, which may provide a method for assaying optimized LVAD support.

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Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

March 16, 2021

Volume

10

Issue

6

Start / End Page

e018588

Location

England

Related Subject Headings

  • Quality of Life
  • Middle Aged
  • Male
  • Humans
  • Heart-Assist Devices
  • Heart Failure
  • Follow-Up Studies
  • Female
  • Diagnostic Techniques, Cardiovascular
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Mainsah, B. O., Patel, P. A., Chen, X. J., Olsen, C., Collins, L. M., & Karra, R. (2021). Novel Acoustic Biomarker of Quality of Life in Left Ventricular Assist Device Recipients. J Am Heart Assoc, 10(6), e018588. https://doi.org/10.1161/JAHA.120.018588
Mainsah, Boyla O., Priyesh A. Patel, Xinlin J. Chen, Cameron Olsen, Leslie M. Collins, and Ravi Karra. “Novel Acoustic Biomarker of Quality of Life in Left Ventricular Assist Device Recipients.J Am Heart Assoc 10, no. 6 (March 16, 2021): e018588. https://doi.org/10.1161/JAHA.120.018588.
Mainsah BO, Patel PA, Chen XJ, Olsen C, Collins LM, Karra R. Novel Acoustic Biomarker of Quality of Life in Left Ventricular Assist Device Recipients. J Am Heart Assoc. 2021 Mar 16;10(6):e018588.
Mainsah, Boyla O., et al. “Novel Acoustic Biomarker of Quality of Life in Left Ventricular Assist Device Recipients.J Am Heart Assoc, vol. 10, no. 6, Mar. 2021, p. e018588. Pubmed, doi:10.1161/JAHA.120.018588.
Mainsah BO, Patel PA, Chen XJ, Olsen C, Collins LM, Karra R. Novel Acoustic Biomarker of Quality of Life in Left Ventricular Assist Device Recipients. J Am Heart Assoc. 2021 Mar 16;10(6):e018588.
Journal cover image

Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

March 16, 2021

Volume

10

Issue

6

Start / End Page

e018588

Location

England

Related Subject Headings

  • Quality of Life
  • Middle Aged
  • Male
  • Humans
  • Heart-Assist Devices
  • Heart Failure
  • Follow-Up Studies
  • Female
  • Diagnostic Techniques, Cardiovascular
  • Aged