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Effect of surface topography on in vitro osteoblast function and mechanical performance of 3D printed titanium.

Publication ,  Journal Article
Abar, B; Kelly, C; Pham, A; Allen, N; Barber, H; Kelly, A; Mirando, AJ; Hilton, MJ; Gall, K; Adams, SB
Published in: J Biomed Mater Res A
October 2021

Critical-sized defects remain a significant challenge in orthopaedics. 3D printed scaffolds are a promising treatment but are still limited due to inconsistent osseous integration. The goal of the study is to understand how changing the surface roughness of 3D printed titanium either by surface treatment or artificially printing rough topography impacts the mechanical and biological properties of 3D printed titanium. Titanium tensile samples and discs were printed via laser powder bed fusion. Roughness was manipulated by post-processing printed samples or by directly printing rough features. Experimental groups in order of increasing surface roughness were Polished, Blasted, As Built, Sprouts, and Rough Sprouts. Tensile behavior of samples showed reduced strength with increasing surface roughness. MC3T3 pre-osteoblasts were seeded on discs and analyzed for cellular proliferation, differentiation, and matrix deposition at 0, 2, and 4 weeks. Printing roughness diminished mechanical properties such as tensile strength and ductility without clear benefit to cell growth. Roughness features were printed on mesoscale, unlike samples in literature in which roughness on microscale demonstrated an increase in cell activity. The data suggest that printing artificial roughness on titanium scaffold is not an effective strategy to promote osseous integration.

Duke Scholars

Published In

J Biomed Mater Res A

DOI

EISSN

1552-4965

Publication Date

October 2021

Volume

109

Issue

10

Start / End Page

1792 / 1802

Location

United States

Related Subject Headings

  • Titanium
  • Tensile Strength
  • Surface Properties
  • Stress, Mechanical
  • Printing, Three-Dimensional
  • Osteocalcin
  • Osteoblasts
  • Mice
  • Collagen
  • Cell Line
 

Citation

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Chicago
ICMJE
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Abar, B., Kelly, C., Pham, A., Allen, N., Barber, H., Kelly, A., … Adams, S. B. (2021). Effect of surface topography on in vitro osteoblast function and mechanical performance of 3D printed titanium. J Biomed Mater Res A, 109(10), 1792–1802. https://doi.org/10.1002/jbm.a.37172
Abar, Bijan, Cambre Kelly, Anh Pham, Nicholas Allen, Helena Barber, Alexander Kelly, Anthony J. Mirando, Matthew J. Hilton, Ken Gall, and Samuel B. Adams. “Effect of surface topography on in vitro osteoblast function and mechanical performance of 3D printed titanium.J Biomed Mater Res A 109, no. 10 (October 2021): 1792–1802. https://doi.org/10.1002/jbm.a.37172.
Abar B, Kelly C, Pham A, Allen N, Barber H, Kelly A, et al. Effect of surface topography on in vitro osteoblast function and mechanical performance of 3D printed titanium. J Biomed Mater Res A. 2021 Oct;109(10):1792–802.
Abar, Bijan, et al. “Effect of surface topography on in vitro osteoblast function and mechanical performance of 3D printed titanium.J Biomed Mater Res A, vol. 109, no. 10, Oct. 2021, pp. 1792–802. Pubmed, doi:10.1002/jbm.a.37172.
Abar B, Kelly C, Pham A, Allen N, Barber H, Kelly A, Mirando AJ, Hilton MJ, Gall K, Adams SB. Effect of surface topography on in vitro osteoblast function and mechanical performance of 3D printed titanium. J Biomed Mater Res A. 2021 Oct;109(10):1792–1802.
Journal cover image

Published In

J Biomed Mater Res A

DOI

EISSN

1552-4965

Publication Date

October 2021

Volume

109

Issue

10

Start / End Page

1792 / 1802

Location

United States

Related Subject Headings

  • Titanium
  • Tensile Strength
  • Surface Properties
  • Stress, Mechanical
  • Printing, Three-Dimensional
  • Osteocalcin
  • Osteoblasts
  • Mice
  • Collagen
  • Cell Line