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Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections.

Publication ,  Journal Article
Manickam, C; Reeves, RK
Published in: Front Microbiol
2014

Hepatitis C virus (HCV) infection has become a global public health burden costing billions of dollars in health care annually. Even with rapidly advancing scientific technologies this disease still poses a significant threat due to a lack of vaccines and affordable treatment options. The immune correlates of protection and predisposing factors toward chronicity remain major obstacles to development of HCV vaccines and immunotherapeutics due, at least in part, to lack of a tangible infection animal model. This review discusses the currently available animal models for HCV disease with a primary focus on GB virus B (GBV-B) infection of New World primates that recapitulates the dual Hepacivirus phenotypes of acute viral clearance and chronic pathologic disease. HCV and GBV-B are also closely phylogenetically related and advances in characterization of the immune systems of New World primates have already led to the use of this model for drug testing and vaccine trials. Herein, we discuss the benefits and caveats of the GBV-B infection model and discuss potential avenues for future development of novel vaccines and immunotherapies.

Duke Scholars

Published In

Front Microbiol

DOI

ISSN

1664-302X

Publication Date

2014

Volume

5

Start / End Page

690

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 0605 Microbiology
  • 0503 Soil Sciences
  • 0502 Environmental Science and Management
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Manickam, C., & Reeves, R. K. (2014). Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections. Front Microbiol, 5, 690. https://doi.org/10.3389/fmicb.2014.00690
Manickam, Cordelia, and R Keith Reeves. “Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections.Front Microbiol 5 (2014): 690. https://doi.org/10.3389/fmicb.2014.00690.
Manickam, Cordelia, and R. Keith Reeves. “Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections.Front Microbiol, vol. 5, 2014, p. 690. Pubmed, doi:10.3389/fmicb.2014.00690.

Published In

Front Microbiol

DOI

ISSN

1664-302X

Publication Date

2014

Volume

5

Start / End Page

690

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 0605 Microbiology
  • 0503 Soil Sciences
  • 0502 Environmental Science and Management