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Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation.

Publication ,  Journal Article
Perikamana, SKM; Seale, N; Hoque, J; Ryu, JH; Kumar, V; Shih, YV; Varghese, S
Published in: Adv Funct Mater
January 19, 2022

Encapsulation of therapeutic cells in a semipermeable device can mitigate the need for systemic immune suppression following cell transplantation by providing local immunoprotection while being permeable to nutrients, oxygen, and different cell-secreted biomolecules. However, fibrotic tissue deposition around the device has been shown to compromise the long-term function of the transplanted cells. Herein, a macroencapsulation device design that improves long-term survival and function of the transplanted cells is reported. The device is comprised of a semipermeable chitosan pouch with a tunable reservoir and molecularly engineered interface. The chitosan pouch interface decorated with 1,12-dodecanedioic acid (DDA), limits the cell adhesion and vigorous foreign body response while maintaining the barrier properties amenable to cell encapsulation. The device provides long-term protection to the encapsulated human primary hepatocytes in the subcutaneous space of immunocompetent mice. The device supports the encapsulated cells for up to 6 months as evident from cell viability and presence of human specific albumin in circulation. Solutions that integrate biomaterials and interfacial engineering such as the one described here may advance development of easy-to manufacture and retrievable devices for the transplantation of therapeutic cells in the absence of immunosuppression.

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Published In

Adv Funct Mater

DOI

ISSN

1616-301X

Publication Date

January 19, 2022

Volume

32

Issue

4

Location

Germany

Related Subject Headings

  • Materials
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences
 

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Perikamana, S. K. M., Seale, N., Hoque, J., Ryu, J. H., Kumar, V., Shih, Y. V., & Varghese, S. (2022). Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation. Adv Funct Mater, 32(4). https://doi.org/10.1002/adfm.202108221
Perikamana, Sajeesh Kumar Madhurakkat, Nailah Seale, Jiaul Hoque, Ji Hyun Ryu, Vardhman Kumar, Yuru Vernon Shih, and Shyni Varghese. “Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation.Adv Funct Mater 32, no. 4 (January 19, 2022). https://doi.org/10.1002/adfm.202108221.
Perikamana SKM, Seale N, Hoque J, Ryu JH, Kumar V, Shih YV, et al. Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation. Adv Funct Mater. 2022 Jan 19;32(4).
Perikamana, Sajeesh Kumar Madhurakkat, et al. “Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation.Adv Funct Mater, vol. 32, no. 4, Jan. 2022. Pubmed, doi:10.1002/adfm.202108221.
Perikamana SKM, Seale N, Hoque J, Ryu JH, Kumar V, Shih YV, Varghese S. Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation. Adv Funct Mater. 2022 Jan 19;32(4).
Journal cover image

Published In

Adv Funct Mater

DOI

ISSN

1616-301X

Publication Date

January 19, 2022

Volume

32

Issue

4

Location

Germany

Related Subject Headings

  • Materials
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences