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Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet

Linking proteostasis, aging, and brain ischemia

Publication ,  Chapter
Yang, W; Li, R; Li, X; Turner, DA
January 1, 2021

Cardiac arrest and ischemic stroke can lead to severe brain dysfunction, due to metabolic stress and loss of protein homeostasis (proteostasis). Further, both metabolic resilience and proteostasis deteriorate with aging, which renders cells inefficient in coping with pathologic consequences of brain ischemia. We describe how aging affects both intrinsic metabolic processes and proteostasis, including several branches of processing by which cells maintain a functional proteome. These pathways of proteostasis include the unfolded protein response, ubiquitination, SUMOylation, and autophagy. Our review further discusses the clinical relevance and how these elements can be pathologically modulated with cardiac arrest and ischemic stroke, as well as potential treatment strategies that may improve resilience and outcome with aging.

Duke Scholars

DOI

ISBN

9780128179901

Publication Date

January 1, 2021

Start / End Page

313 / 324
 

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Yang, W., Li, R., Li, X., & Turner, D. A. (2021). Linking proteostasis, aging, and brain ischemia. In Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet (pp. 313–324). https://doi.org/10.1016/B978-0-12-817990-1.00028-7
Yang, W., R. Li, X. Li, and D. A. Turner. “Linking proteostasis, aging, and brain ischemia.” In Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet, 313–24, 2021. https://doi.org/10.1016/B978-0-12-817990-1.00028-7.
Yang W, Li R, Li X, Turner DA. Linking proteostasis, aging, and brain ischemia. In: Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet. 2021. p. 313–24.
Yang, W., et al. “Linking proteostasis, aging, and brain ischemia.” Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet, 2021, pp. 313–24. Scopus, doi:10.1016/B978-0-12-817990-1.00028-7.
Yang W, Li R, Li X, Turner DA. Linking proteostasis, aging, and brain ischemia. Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet. 2021. p. 313–324.
Journal cover image

DOI

ISBN

9780128179901

Publication Date

January 1, 2021

Start / End Page

313 / 324