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HNF-4alpha: from MODY to late-onset type 2 diabetes.

Publication ,  Journal Article
Gupta, RK; Kaestner, KH
Published in: Trends Mol Med
November 2004

Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4alpha (HNF-4alpha). Odom and colleagues have combined chromatin immunoprecipitation with promoter microarrays to identify numerous promoters occupied by HNF-4alpha in the human liver and islet, suggesting a very broad role for HNF-4alpha in glucose homeostasis. This notion is supported by recent genetic studies linking HNF-4alpha to the much more common late-onset type 2 diabetes.

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Published In

Trends Mol Med

DOI

ISSN

1471-4914

Publication Date

November 2004

Volume

10

Issue

11

Start / End Page

521 / 524

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Phosphoproteins
  • Islets of Langerhans
  • Infant
  • Immunology
  • Humans
  • Homeostasis
 

Citation

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Gupta, R. K., & Kaestner, K. H. (2004). HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends Mol Med, 10(11), 521–524. https://doi.org/10.1016/j.molmed.2004.09.004
Gupta, Rana K., and Klaus H. Kaestner. “HNF-4alpha: from MODY to late-onset type 2 diabetes.Trends Mol Med 10, no. 11 (November 2004): 521–24. https://doi.org/10.1016/j.molmed.2004.09.004.
Gupta RK, Kaestner KH. HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends Mol Med. 2004 Nov;10(11):521–4.
Gupta, Rana K., and Klaus H. Kaestner. “HNF-4alpha: from MODY to late-onset type 2 diabetes.Trends Mol Med, vol. 10, no. 11, Nov. 2004, pp. 521–24. Pubmed, doi:10.1016/j.molmed.2004.09.004.
Gupta RK, Kaestner KH. HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends Mol Med. 2004 Nov;10(11):521–524.
Journal cover image

Published In

Trends Mol Med

DOI

ISSN

1471-4914

Publication Date

November 2004

Volume

10

Issue

11

Start / End Page

521 / 524

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Phosphoproteins
  • Islets of Langerhans
  • Infant
  • Immunology
  • Humans
  • Homeostasis