HNF-4alpha: from MODY to late-onset type 2 diabetes.
Publication
, Journal Article
Gupta, RK; Kaestner, KH
Published in: Trends Mol Med
November 2004
Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4alpha (HNF-4alpha). Odom and colleagues have combined chromatin immunoprecipitation with promoter microarrays to identify numerous promoters occupied by HNF-4alpha in the human liver and islet, suggesting a very broad role for HNF-4alpha in glucose homeostasis. This notion is supported by recent genetic studies linking HNF-4alpha to the much more common late-onset type 2 diabetes.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Trends Mol Med
DOI
ISSN
1471-4914
Publication Date
November 2004
Volume
10
Issue
11
Start / End Page
521 / 524
Location
England
Related Subject Headings
- Transcription, Genetic
- Transcription Factors
- Promoter Regions, Genetic
- Polymorphism, Single Nucleotide
- Phosphoproteins
- Islets of Langerhans
- Infant
- Immunology
- Humans
- Homeostasis
Citation
APA
Chicago
ICMJE
MLA
NLM
Gupta, R. K., & Kaestner, K. H. (2004). HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends Mol Med, 10(11), 521–524. https://doi.org/10.1016/j.molmed.2004.09.004
Gupta, Rana K., and Klaus H. Kaestner. “HNF-4alpha: from MODY to late-onset type 2 diabetes.” Trends Mol Med 10, no. 11 (November 2004): 521–24. https://doi.org/10.1016/j.molmed.2004.09.004.
Gupta RK, Kaestner KH. HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends Mol Med. 2004 Nov;10(11):521–4.
Gupta, Rana K., and Klaus H. Kaestner. “HNF-4alpha: from MODY to late-onset type 2 diabetes.” Trends Mol Med, vol. 10, no. 11, Nov. 2004, pp. 521–24. Pubmed, doi:10.1016/j.molmed.2004.09.004.
Gupta RK, Kaestner KH. HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends Mol Med. 2004 Nov;10(11):521–524.
Published In
Trends Mol Med
DOI
ISSN
1471-4914
Publication Date
November 2004
Volume
10
Issue
11
Start / End Page
521 / 524
Location
England
Related Subject Headings
- Transcription, Genetic
- Transcription Factors
- Promoter Regions, Genetic
- Polymorphism, Single Nucleotide
- Phosphoproteins
- Islets of Langerhans
- Infant
- Immunology
- Humans
- Homeostasis