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The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation.

Publication ,  Journal Article
Pleasants, RA; Bedoya, AD; Boggan, JM; Welty-Wolf, K; Tighe, RM
Published in: Pulm Ther
September 2022

INTRODUCTION: The disease origins of idiopathic pulmonary fibrosis (IPF), which occurs at higher rates in certain races/ethnicities, are not understood. The highest rates occur in white persons of European descent, particularly those with light skin, who are also susceptible to lysosomal organelle dysfunction of the skin leading to fibroproliferative disease . We had observed clinically that the vast majority of patients with IPF had light-colored eyes, suggesting a phenotypic characteristic. METHODS: We pursued this observation through a research database from the USA Veterans Administration, a population that has a high occurrence of IPF due to predominance of elderly male smokers. Using this medical records database, which included facial photos, we compared the frequency of light (blue, green, hazel) and dark (light brown, brown) eyes among white patients diagnosed with IPF compared with a control group of lung granuloma only (no other radiologic evidence of interstitial lung disease). RESULTS: Light eye color was significantly more prevalent in patients with IPF than in the control group with lung granuloma [114/147 (77.6%) versus 129/263 (49.0%], p < 0.001), indicating that light-colored eyes are a phenotype associated with IPF . CONCLUSION: We provide evidence that light eye color is predominant among white persons with IPF.

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Published In

Pulm Ther

DOI

EISSN

2364-1746

Publication Date

September 2022

Volume

8

Issue

3

Start / End Page

327 / 331

Location

United States
 

Citation

APA
Chicago
ICMJE
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Pleasants, R. A., Bedoya, A. D., Boggan, J. M., Welty-Wolf, K., & Tighe, R. M. (2022). The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation. Pulm Ther, 8(3), 327–331. https://doi.org/10.1007/s41030-022-00198-5
Pleasants, Roy A., Armando D. Bedoya, Joel M. Boggan, Karen Welty-Wolf, and Robert M. Tighe. “The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation.Pulm Ther 8, no. 3 (September 2022): 327–31. https://doi.org/10.1007/s41030-022-00198-5.
Pleasants RA, Bedoya AD, Boggan JM, Welty-Wolf K, Tighe RM. The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation. Pulm Ther. 2022 Sep;8(3):327–31.
Pleasants, Roy A., et al. “The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation.Pulm Ther, vol. 8, no. 3, Sept. 2022, pp. 327–31. Pubmed, doi:10.1007/s41030-022-00198-5.
Pleasants RA, Bedoya AD, Boggan JM, Welty-Wolf K, Tighe RM. The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation. Pulm Ther. 2022 Sep;8(3):327–331.
Journal cover image

Published In

Pulm Ther

DOI

EISSN

2364-1746

Publication Date

September 2022

Volume

8

Issue

3

Start / End Page

327 / 331

Location

United States