Karen Elizabeth Welty-Wolf

Karen Elizabeth Welty-Wolf
Professor of Medicine

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2017

Contact Information

0570 Clin Res II, Durham, NC 27710
Duke Box 3518, Durham, NC 27710
welty001@mc.duke.edu (919) 684-4938

Background
Education, Training, & Certifications
- Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University 1990 - 1993
- Fellow in Infectious Diseases, Medicine, Duke University 1989 - 1990
- Medical Resident, Medicine, Duke University 1986 - 1989
- M.D., Duke University 1986
Duke Appointment History
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2007 - 2017
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1997 - 2007
- Associate in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1993 - 1997
Research
Selected Grants
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2020
- A Phase II Study of Inhaled Carbon Monoxide for the Treatment of ARDS 2018 - 2019
- Novel Dialysis-Like Therapeutics in Sepsis-induced Shock and Organ Failure 2015 - 2018
- Project 2: Regulation of Mitochondrial Quality Control by Heme Oxygenase-1 System in Sepsis awarded by Brigham and Women's Hospital 2011 - 2017
- Telephone-based coping skills training for COPD awarded by National Institutes of Health 2000 - 2014
- Mitochondrial biogenesis in sepsis-induced organ dysfunction awarded by National Institutes of Health 2009 - 2013
- Lung Injury Protection by Coagulation Blockade awarded by National Institutes of Health 2005 - 2010
- Acute Lung Injury Mechanisms And Therapy awarded by National Institutes of Health 1984 - 1999
- Acute Lung Injury - Mechanisms And Therapy awarded by National Institutes of Health 1984 - 1997
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kraft, Bryan D., Lingye Chen, Hagir B. Suliman, Claude A. Piantadosi, and Karen E. Welty-Wolf. “Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis..” Crit Care Med 47, no. 5 (May 2019): 651–58. https://doi.org/10.1097/CCM.0000000000003681.
    Full Text Link to Item
  - Chen, Lingye, Karen E. Welty-Wolf, and Bryan D. Kraft. “Nonhuman primate species as models of human bacterial sepsis..” Lab Anim (Ny) 48, no. 2 (February 2019): 57–65. https://doi.org/10.1038/s41684-018-0217-2.
    Full Text Link to Item
  - Fredenburgh, Laura E., Mark A. Perrella, Diana Barragan-Bradford, Dean R. Hess, Elizabeth Peters, Karen E. Welty-Wolf, Bryan D. Kraft, et al. “A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS..” Jci Insight 3, no. 23 (December 6, 2018). https://doi.org/10.1172/jci.insight.124039.
    Full Text Link to Item
  - Suliman, Hagir B., Bryan Kraft, Raquel Bartz, Lingye Chen, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice..” Am J Physiol Lung Cell Mol Physiol 313, no. 4 (October 1, 2017): L699–709. https://doi.org/10.1152/ajplung.00197.2017.
    Full Text Link to Item
  - Tsalik, Ephraim L., Yanhong Li, Lori L. Hudson, Vivian H. Chu, Tiffany Himmel, Alex T. Limkakeng, Jason N. Katz, et al. “Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients..” Ann Am Thorac Soc 13, no. 3 (March 2016): 401–13. https://doi.org/10.1513/AnnalsATS.201504-205OC.
    Full Text Open Access Copy Link to Item
  - Blumenthal, James A., Patrick J. Smith, Michael Durheim, Stephanie Mabe, Charles F. Emery, Tereza Martinu, Philip T. Diaz, Michael Babyak, Karen Welty-Wolf, and Scott Palmer. “Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial..” Psychosom Med 78, no. 2 (February 2016): 153–62. https://doi.org/10.1097/PSY.0000000000000260.
    Full Text Link to Item
  - Fredenburgh, Laura E., Bryan D. Kraft, Dean R. Hess, R Scott Harris, Monroe A. Wolf, Hagir B. Suliman, Victor L. Roggli, et al. “Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia..” Am J Physiol Lung Cell Mol Physiol 309, no. 8 (October 15, 2015): L834–46. https://doi.org/10.1152/ajplung.00240.2015.
    Full Text Link to Item
  - Pecorella, Shelly R. H., Jennifer V. F. Potter, Anne D. Cherry, Dionne F. Peacher, Karen E. Welty-Wolf, Richard E. Moon, Claude A. Piantadosi, and Hagir B. Suliman. “The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle..” Am J Physiol Lung Cell Mol Physiol 309, no. 8 (October 15, 2015): L857–71. https://doi.org/10.1152/ajplung.00104.2015.
    Full Text Link to Item
  - Dalli, Jesmond, Bryan D. Kraft, Romain A. Colas, Masakazu Shinohara, Laura E. Fredenburgh, Dean R. Hess, Nan Chiang, et al. “The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide..” Am J Respir Cell Mol Biol 53, no. 3 (September 2015): 314–25. https://doi.org/10.1165/rcmb.2014-0299OC.
    Full Text Link to Item
  - Durheim, Michael T., Patrick J. Smith, Michael A. Babyak, Stephanie K. Mabe, Tereza Martinu, Karen E. Welty-Wolf, Charles F. Emery, Scott M. Palmer, and James A. Blumenthal. “Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group..” Ann Am Thorac Soc 12, no. 3 (March 2015): 349–56. https://doi.org/10.1513/AnnalsATS.201408-365OC.
    Full Text Link to Item
  - Blumenthal, James A., Charles F. Emery, Patrick J. Smith, Francis J. Keefe, Karen Welty-Wolf, Stephanie Mabe, Tereza Martinu, et al. “The effects of a telehealth coping skills intervention on outcomes in chronic obstructive pulmonary disease: primary results from the INSPIRE-II study..” Psychosom Med 76, no. 8 (October 2014): 581–92. https://doi.org/10.1097/PSY.0000000000000101.
    Full Text Link to Item
  - Kraft, Bryan D., Claude A. Piantadosi, Ashlee M. Benjamin, Joseph E. Lucas, Aimee K. Zaas, Marisol Betancourt-Quiroz, Christopher W. Woods, et al. “Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates..” Am J Respir Cell Mol Biol 50, no. 5 (May 2014): 995–1004. https://doi.org/10.1165/rcmb.2013-0340OC.
    Full Text Link to Item
  - Bartz, Raquel R., Ping Fu, Hagir B. Suliman, Stephen D. Crowley, Nancy Chou MacGarvey, Karen Welty-Wolf, and Claude A. Piantadosi. “Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice..” Plos One 9, no. 7 (2014). https://doi.org/10.1371/journal.pone.0100912.
    Full Text Link to Item
  - Doyle, Todd, Scott Palmer, Julie Johnson, Michael A. Babyak, Patrick Smith, Stephanie Mabe, Karen Welty-Wolf, Tereza Martinu, and James A. Blumenthal. “Association of anxiety and depression with pulmonary-specific symptoms in chronic obstructive pulmonary disease..” Int J Psychiatry Med 45, no. 2 (2013): 189–202. https://doi.org/10.2190/PM.45.2.g.
    Full Text Link to Item
  - Athale, Janhavi, Allison Ulrich, Nancy Chou MacGarvey, Raquel R. Bartz, Karen E. Welty-Wolf, Hagir B. Suliman, and Claude A. Piantadosi. “Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice..” Free Radic Biol Med 53, no. 8 (October 15, 2012): 1584–94. https://doi.org/10.1016/j.freeradbiomed.2012.08.009.
    Full Text Link to Item
  - Piantadosi, Claude A., Raquel R. Bartz, Martha S. Carraway, Andrew J. Ghio, Timothy J. McMahon, David M. Murdoch, Victor L. Roggli, et al. “The opprobrium of Big Tobacco..” Am J Respir Crit Care Med 185, no. 9 (May 1, 2012). https://doi.org/10.1164/ajrccm.185.9.1030.
    Full Text Link to Item
  - MacGarvey, Nancy Chou, Hagir B. Suliman, Raquel R. Bartz, Ping Fu, Crystal M. Withers, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis..” Am J Respir Crit Care Med 185, no. 8 (April 15, 2012): 851–61. https://doi.org/10.1164/rccm.201106-1152OC.
    Full Text Link to Item
  - Piantadosi, Claude A., Crystal M. Withers, Raquel R. Bartz, Nancy Chou MacGarvey, Ping Fu, Timothy E. Sweeney, Karen E. Welty-Wolf, and Hagir B. Suliman. “Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression..” J Biol Chem 286, no. 18 (May 6, 2011): 16374–85. https://doi.org/10.1074/jbc.M110.207738.
    Full Text Link to Item
  - Bartz, Raquel R., Hagir B. Suliman, Ping Fu, Karen Welty-Wolf, Martha Sue Carraway, Nancy Chou MacGarvey, Crystal M. Withers, Timothy E. Sweeney, and Claude A. Piantadosi. “Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice..” Am J Respir Crit Care Med 183, no. 2 (January 15, 2011): 226–33. https://doi.org/10.1164/rccm.200911-1709OC.
    Full Text Link to Item
  - Sweeney, Timothy E., Hagir B. Suliman, John W. Hollingsworth, Karen E. Welty-Wolf, and Claude A. Piantadosi. “A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis..” Plos One 6, no. 9 (2011). https://doi.org/10.1371/journal.pone.0025249.
    Full Text Link to Item
  - Suliman, Hagir B., Abdelwahid Babiker, Crystal M. Withers, Timothy E. Sweeney, Martha S. Carraway, Lynn G. Tatro, Raquel R. Bartz, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice..” Free Radic Biol Med 48, no. 5 (March 1, 2010): 736–46. https://doi.org/10.1016/j.freeradbiomed.2009.12.019.
    Full Text Link to Item
  - Reynolds, Crystal M., Hagir B. Suliman, John W. Hollingsworth, Karen E. Welty-Wolf, Martha Sue Carraway, and Claude A. Piantadosi. “Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia..” Free Radic Biol Med 46, no. 5 (March 1, 2009): 564–72. https://doi.org/10.1016/j.freeradbiomed.2008.11.007.
    Full Text Link to Item
  - Reddy, Anita J., Christopher W. Woods, and Karen E. Welty-Wolf. “Eastern equine encephalitis leading to multi-organ failure and sepsis..” J Clin Virol 42, no. 4 (August 2008): 418–21. https://doi.org/10.1016/j.jcv.2008.03.008.
    Full Text Link to Item
  - Carraway, Martha S., Hagir B. Suliman, Corrine Kliment, Karen E. Welty-Wolf, Tim D. Oury, and Claude A. Piantadosi. “Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis..” Antioxid Redox Signal 10, no. 2 (February 2008): 269–75. https://doi.org/10.1089/ars.2007.1910.
    Full Text Link to Item
  - Suliman, Hagir B., Martha Sue Carraway, Abdelwahid S. Ali, Chrystal M. Reynolds, Karen E. Welty-Wolf, and Claude A. Piantadosi. “The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy..” J Clin Invest 117, no. 12 (December 2007): 3730–41. https://doi.org/10.1172/JCI32967.
    Full Text Open Access Copy Link to Item
  - Haden, Douglas W., Hagir B. Suliman, Martha Sue Carraway, Karen E. Welty-Wolf, Abdelwahid S. Ali, Hiroshi Shitara, Hiromichi Yonekawa, and Claude A. Piantadosi. “Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis..” Am J Respir Crit Care Med 176, no. 8 (October 15, 2007): 768–77. https://doi.org/10.1164/rccm.200701-161OC.
    Full Text Link to Item
  - Demchenko, Ivan T., Karen E. Welty-Wolf, Barry W. Allen, and Claude A. Piantadosi. “Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide..” Am J Physiol Lung Cell Mol Physiol 293, no. 1 (July 2007): L229–38. https://doi.org/10.1152/ajplung.00450.2006.
    Full Text Link to Item
  - Ware, Lorraine B., Eric Camerer, Karen Welty-Wolf, Marcus J. Schultz, and Michael A. Matthay. “Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury..” Am J Physiol Lung Cell Mol Physiol 291, no. 3 (September 2006): L307–11. https://doi.org/10.1152/ajplung.00157.2006.
    Full Text Link to Item
  - Roggli, Victor L., Claude A. Piantadosi, Neil R. MacIntyre, Stephen L. Young, Peter S. Kussin, Mark P. Steele, Martha Sue Carraway, et al. “Physician subsidies for tobacco advertising..” Am J Respir Crit Care Med 173, no. 2 (January 15, 2006). https://doi.org/10.1164/ajrccm.173.2.246.
    Full Text Link to Item
  - Welty-Wolf, Karen E., Martha S. Carraway, Thomas L. Ortel, Andrew J. Ghio, Steven Idell, Jack Egan, Xiaoyun Zhu, Jin-an Jiao, Hing C. Wong, and Claude A. Piantadosi. “Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure..” Am J Physiol Lung Cell Mol Physiol 290, no. 1 (January 2006): L21–31. https://doi.org/10.1152/ajplung.00155.2005.
    Full Text Link to Item
  - Suliman, Hagir B., Karen E. Welty-Wolf, Martha Sue Carraway, David A. Schwartz, John W. Hollingsworth, and Claude A. Piantadosi. “Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli..” Faseb J 19, no. 11 (September 2005): 1531–33. https://doi.org/10.1096/fj.04-3500fje.
    Full Text Link to Item
  - Suliman, Hagir B., Karen E. Welty-Wolf, Marthasue Carraway, Lynn Tatro, and Claude A. Piantadosi. “Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis..” Cardiovasc Res 64, no. 2 (November 1, 2004): 279–88. https://doi.org/10.1016/j.cardiores.2004.07.005.
    Full Text Link to Item
  - Suliman, Hagir B., Martha S. Carraway, Karen E. Welty-Wolf, A Richard Whorton, and Claude A. Piantadosi. “Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1..” J Biol Chem 278, no. 42 (October 17, 2003): 41510–18. https://doi.org/10.1074/jbc.M304719200.
    Full Text Link to Item
  - Carraway, Martha Sue, Karen E. Welty-Wolf, Debra L. Miller, Thomas L. Ortel, Steven Idell, Andrew J. Ghio, Lars C. Petersen, and Claude A. Piantadosi. “Blockade of tissue factor: treatment for organ injury in established sepsis..” Am J Respir Crit Care Med 167, no. 9 (May 1, 2003): 1200–1209. https://doi.org/10.1164/rccm.200204-287OC.
    Full Text Link to Item
  - Welty-Wolf, Karen E., Martha S. Carraway, Thomas L. Ortel, and Claude A. Piantadosi. “Coagulation and inflammation in acute lung injury..” Thromb Haemost 88, no. 1 (July 2002): 17–25.
    Link to Item
  - Miller, Debra L., Karen Welty-Wolf, Martha Sue Carraway, Mirella Ezban, Andrew Ghio, Hagir Suliman, and Claude A. Piantadosi. “Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide..” Am J Respir Cell Mol Biol 26, no. 6 (June 2002): 650–58. https://doi.org/10.1165/ajrcmb.26.6.4688.
    Full Text Link to Item
  - Welty-Wolf, K. E., M. S. Carraway, D. L. Miller, T. L. Ortel, M. Ezban, A. J. Ghio, S. Idell, and C. A. Piantadosi. “Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons..” Am J Respir Crit Care Med 164, no. 10 Pt 1 (November 15, 2001): 1988–96. https://doi.org/10.1164/ajrccm.164.10.2105027.
    Full Text Link to Item
  - Welty-Wolf, K. E., M. S. Carraway, S. Idell, T. L. Ortel, M. Ezban, and C. A. Piantadosi. “Tissue factor in experimental acute lung injury..” Semin Hematol 38, no. 4 Suppl 12 (October 2001): 35–38.
    Link to Item
  - Auten, R. L., S. N. Mason, D. T. Tanaka, K. Welty-Wolf, and M. H. Whorton. “Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats.” American Journal of Physiology Lung Cellular and Molecular Physiology 281, no. 2 25-2 (August 29, 2001).
  - Welty-Wolf, K. E., M. S. Carraway, Y. C. Huang, S. G. Simonson, S. P. Kantrow, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis..” Am J Respir Crit Care Med 163, no. 3 Pt 1 (March 2001): 665–73. https://doi.org/10.1164/ajrccm.163.3.2004191.
    Full Text Link to Item
  - Welty-Wolf, K. E., M. S. Carraway, S. Idell, T. L. Ortel, M. Ezban, and C. A. Piantadosi. “Tissue factor in experimental acute lung injury.” Seminars in Hematology 38, no. 4 SUPPL. 12 (January 1, 2001): 35–38.
  - Welty-Wolf, K. E., M. S. Carraway, A. Ghio, S. P. Kantrow, Y. C. Huang, and C. A. Piantadosi. “Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy..” Shock 13, no. 5 (May 2000): 404–9.
    Link to Item
  - Welty-Wolf, K. E., and C. A. Piantadosi. “LPS amplifies or attenuates endotoxin-induced acute lung injury in mice depending on route of priming exposure..” American Journal of Respiratory and Critical Care Medicine 159, no. 3 (March 1, 1999): A599–A599.
    Link to Item
  - Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. T. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons.” American Journal of Respiratory and Critical Care Medicine 157, no. 3 PART I (December 1, 1998): 938–49.
  - Welty-Wolf, K. E., M. S. Carraway, Y. C. Huang, S. G. Simonson, S. P. Kantrow, and C. A. Piantadosi. “Bacterial priming increases lung injury in gram-negative sepsis..” Am J Respir Crit Care Med 158, no. 2 (August 1998): 610–19. https://doi.org/10.1164/ajrccm.158.2.9704064.
    Full Text Link to Item
  - Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons..” Am J Respir Crit Care Med 157, no. 3 Pt 1 (March 1998): 938–49. https://doi.org/10.1164/ajrccm.157.3.9707129.
    Full Text Link to Item
  - Simonson, S. G., K. E. Welty-Wolf, Y. C. Huang, D. E. Taylor, S. P. Kantrow, M. S. Carraway, J. D. Crapo, and C. A. Piantadosi. “Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry..” J Appl Physiol (1985) 83, no. 2 (August 1997): 550–58. https://doi.org/10.1152/jappl.1997.83.2.550.
    Full Text Link to Item
  - Welty-Wolf, K. E., S. G. Simonson, Y. C. Huang, S. P. Kantrow, M. S. Carraway, L. Y. Chang, J. D. Crapo, and C. A. Piantadosi. “Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis..” J Appl Physiol (1985) 83, no. 2 (August 1997): 559–68. https://doi.org/10.1152/jappl.1997.83.2.559.
    Full Text Link to Item
  - Simonson, S. G., Y. C. Huang, P. J. Fracica, K. E. Welty-Wolf, R. E. Moon, S. L. Young, and C. A. Piantadosi. “Changes in the lung after prolonged positive pressure ventilation in normal baboons..” J Crit Care 12, no. 2 (June 1997): 72–82.
    Link to Item
  - Huang, Y. C., P. J. Fracica, S. G. Simonson, J. D. Crapo, S. L. Young, K. E. Welty-Wolf, R. E. Moon, and C. A. Piantadosi. “VA/Q abnormalities during gram negative sepsis..” Respir Physiol 105, no. 1–2 (August 1996): 109–21. https://doi.org/10.1016/0034-5687(96)00039-4.
    Full Text Link to Item
  - Kanj, S. S., K. Welty-Wolf, J. Madden, V. Tapson, M. A. Baz, R. D. Davis, and J. R. Perfect. “Fungal infections in lung and heart-lung transplant recipients. Report of 9 cases and review of the literature..” Medicine (Baltimore) 75, no. 3 (May 1996): 142–56. https://doi.org/10.1097/00005792-199605000-00004.
    Full Text Link to Item
  - Welty-Wolf, K. E., S. G. Simonson, Y. C. Huang, P. J. Fracica, J. W. Patterson, and C. A. Piantadosi. “Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis..” Shock 5, no. 5 (May 1996): 378–84.
    Link to Item
  - Piantadosi, C. A., P. J. Fracica, F. G. Duhaylongsod, Y. C. Huang, K. E. Welty-Wolf, J. D. Crapo, and S. L. Young. “Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis..” J Appl Physiol (1985) 78, no. 5 (May 1995): 1823–31. https://doi.org/10.1152/jappl.1995.78.5.1823.
    Full Text Link to Item
  - Welty-Wolf, K. “Pulmonary Function: A Guide for Clinicians.” Bmj 309, no. 6967 (December 3, 1994). https://doi.org/10.1136/bmj.309.6967.1521.
    Full Text
  - Simonson, S. G., K. Welty-Wolf, Y. T. Huang, J. A. Griebel, M. S. Caplan, P. J. Fracica, and C. A. Piantadosi. “Altered mitochondrial redox responses in gram negative septic shock in primates..” Circ Shock 43, no. 1 (May 1994): 34–43.
    Link to Item
  - Kim, J. H., R. A. Cooper, K. E. Welty-Wolf, L. J. Harrell, P. Zwadyk, and M. E. Klotman. “Pseudomonas putrefaciens bacteremia..” Rev Infect Dis 11, no. 1 (January 1989): 97–104.
    Link to Item
- Conference Papers
  - Chen, L., B. D. Kraft, V. L. Roggli, H. B. Suliman, C. A. Piantadosi, and K. E. Welty-Wolf. “Severe Pneumococcal Pneumonia Causes Cardiac and Skeletal Muscle Injuries in Baboons.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Pleasants, R. A., A. Bedoya, R. Kundich, J. Boggan, A. Reihman, D. Seaman, L. Howard, K. E. Welty-Wolf, and R. M. Tighe. “Characteristics of Connective Tissue Related Interstitial Lung Disease in the Mid- Atlantic Veterans Affairs Regional Network.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Reihman, A., A. Bedoya, R. A. Pleasants, J. Boggan, L. Howard, R. Kundich, K. E. Welty-Wolf, and R. M. Tighe. “Initial Pulmonary Function Patterns Define Clinical Characteristics in Veterans Affairs Cohort with Interstitial Lung Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Bedoya, A. D., R. Pleasants, J. Boggan, D. Seaman, L. Howard, A. Reihman, K. Welty-Wolf, and R. M. Tighe. “Characteristics Of Interstitial Lung Disease In The Mid-Atlantic Veterans Affairs Regional Network.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
    Link to Item
  - Kraft, B., C. A. Piantadosi, H. B. Suliman, G. S. Ginsburg, R. R. Bartz, A. Zaas, M. Betancourt, and K. E. Welty-Wolf. “Pneumococcal Pneumonia And Sepsis In Baboons Mirrors The Human Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.
    Link to Item
  - Piantadosi, Claude A., Crystal M. Withers, Raquel R. Bartz, Nancy C. MacGarvey, Timothy E. Sweeney, Karen E. Welty-Wolf, and Hagir B. Suliman. “Redox Activation of Mitochondrial Biogenesis by Heme Oxygenase-1 Exerts Counter-regulatory Control over NF-kB-dependent Cytokine Production.” In Faseb Journal, Vol. 25. FEDERATION AMER SOC EXP BIOL, 2011.
    Link to Item
  - Reynolds, Crystal M., Hagir B. Suliman, Matha Sue Carraway, John W. Hollingsworth, Kern E. Welty-Wolf, and Claude A. Piantadosi. “Nitric oxide and toll-like receptor 4 are required for cardiac mitochondrial biogenesis after endotoxemia.” In Free Radical Biology and Medicine, 43:S144–S144. ELSEVIER SCIENCE INC, 2007.
    Link to Item
  - Babiker, Abdelwahid Saeed, Hagir B. Suliman, Martha Sue Carraway, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Mitochondrial biogenesis in sepsis: a role for inducible nitric oxide synthase.” In Free Radical Biology and Medicine, 41:S47–S47. ELSEVIER SCIENCE INC, 2006.
    Link to Item
  - Suliman, Hagir B., Martha Sue Carraway, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Carbon monoxide protects against mitochondrial damage in doxorubicin-induced myocardial dysfunction.” In Free Radical Biology and Medicine, 41:S152–S152. ELSEVIER SCIENCE INC, 2006.
    Link to Item
  - Piantadosi, Claude A., Martha Sue Carraway, Karen E. Welty-Wolf, and Hagir B. Suliman. “OXIDATIVE DAMAGE OF MITOCHONDRIA AND MITOCHONDRIAL DNA IN SEPSIS..” In Shock, 21:57–57. Ovid Technologies (Wolters Kluwer Health), 2004. https://doi.org/10.1097/00024382-200403001-00228.
    Full Text
  - Miller, D. L., K. E. Welty-Wolf, M. S. Carraway, C. A. Piantadosi, and L. C. Petersen. “Competitive inhibition of Factor VIIa regulates bronchoalveolar lavage cell activation after intratracheal lipopolysaccharide.” In Faseb Journal, 17:C71–C71. FEDERATION AMER SOC EXP BIOL, 2003.
    Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers