Karen Elizabeth Welty-Wolf

Karen Elizabeth Welty-Wolf
Professor of Medicine

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2017

Contact Information

0570 Clin Res II, Durham, NC 27710
Duke Box 3518, Durham, NC 27710
welty001@mc.duke.edu (919) 684-4938

Background
Education, Training, & Certifications
- Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University 1990 - 1993
- Fellow in Infectious Diseases, Medicine, Duke University 1989 - 1990
- Medical Resident, Medicine, Duke University 1986 - 1989
- M.D., Duke University 1986
Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2007 - 2017
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1997 - 2007
- Associate in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1993 - 1997
Research
Selected Grants
- A Phase II Study of Inhaled Carbon Monoxide for the Treatment of ARDS awarded by Weill Medical College of Cornell University 2018 - 2022
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2021
- Novel Dialysis-Like Therapeutics in Sepsis-induced Shock and Organ Failure awarded by Defense Advanced Research Projects Agency 2015 - 2018
- Project 2: Regulation of Mitochondrial Quality Control by Heme Oxygenase-1 System in Sepsis awarded by Brigham and Women's Hospital 2011 - 2017
- Telephone-based coping skills training for COPD awarded by National Institutes of Health 2000 - 2014
- Mitochondrial biogenesis in sepsis-induced organ dysfunction awarded by National Institutes of Health 2009 - 2013
- Lung Injury Protection by Coagulation Blockade awarded by National Institutes of Health 2005 - 2010
- Acute Lung Injury Mechanisms And Therapy awarded by National Institutes of Health 1984 - 1999
- Acute Lung Injury - Mechanisms And Therapy awarded by National Institutes of Health 1984 - 1997
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Pleasants, Roy A., Armando D. Bedoya, Joel M. Boggan, Karen Welty-Wolf, and Robert M. Tighe. “The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation.” Pulm Ther 8, no. 3 (September 2022): 327–31. https://doi.org/10.1007/s41030-022-00198-5.
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  - Suliman, Hagir B., Zachary Healy, Fabio Zobi, Bryan D. Kraft, Karen Welty-Wolf, Joshua Smith, Christina Barkauskas, and Claude A. Piantadosi. “Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis.” Iscience 25, no. 1 (January 21, 2022): 103535. https://doi.org/10.1016/j.isci.2021.103535.
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  - Chen, Lingye, Bryan D. Kraft, Victor L. Roggli, Zachary R. Healy, Christopher W. Woods, Ephraim L. Tsalik, Geoffrey S. Ginsburg, et al. “Heparin-based blood purification attenuates organ injury in baboons with Streptococcus pneumoniae pneumonia.” Am J Physiol Lung Cell Mol Physiol 321, no. 2 (August 1, 2021): L321–35. https://doi.org/10.1152/ajplung.00337.2020.
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  - Bedoya, Armando, Roy A. Pleasants, Joel C. Boggan, Danielle Seaman, Anne Reihman, Lauren Howard, Robert Kundich, Karen Welty-Wolf, and Robert M. Tighe. “Interstitial lung disease in a veterans affairs regional network; a retrospective cohort study.” Plos One 16, no. 3 (2021): e0247316. https://doi.org/10.1371/journal.pone.0247316.
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  - Stanfield, Brent A., Todd Purves, Scott Palmer, Bruce Sullenger, Karen Welty-Wolf, Krista Haines, Suresh Agarwal, and George Kasotakis. “IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages.” Plos One 16, no. 1 (2021): e0245169. https://doi.org/10.1371/journal.pone.0245169.
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  - Kraft, Bryan D., Lingye Chen, Hagir B. Suliman, Claude A. Piantadosi, and Karen E. Welty-Wolf. “Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis.” Crit Care Med 47, no. 5 (May 2019): 651–58. https://doi.org/10.1097/CCM.0000000000003681.
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  - Chen, Lingye, Karen E. Welty-Wolf, and Bryan D. Kraft. “Nonhuman primate species as models of human bacterial sepsis.” Lab Anim (Ny) 48, no. 2 (February 2019): 57–65. https://doi.org/10.1038/s41684-018-0217-2.
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  - Fredenburgh, Laura E., Mark A. Perrella, Diana Barragan-Bradford, Dean R. Hess, Elizabeth Peters, Karen E. Welty-Wolf, Bryan D. Kraft, et al. “A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.” Jci Insight 3, no. 23 (December 6, 2018). https://doi.org/10.1172/jci.insight.124039.
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  - Suliman, Hagir B., Bryan Kraft, Raquel Bartz, Lingye Chen, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice.” Am J Physiol Lung Cell Mol Physiol 313, no. 4 (October 1, 2017): L699–709. https://doi.org/10.1152/ajplung.00197.2017.
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  - Tsalik, Ephraim L., Yanhong Li, Lori L. Hudson, Vivian H. Chu, Tiffany Himmel, Alex T. Limkakeng, Jason N. Katz, et al. “Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.” Ann Am Thorac Soc 13, no. 3 (March 2016): 401–13. https://doi.org/10.1513/AnnalsATS.201504-205OC.
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  - Blumenthal, James A., Patrick J. Smith, Michael Durheim, Stephanie Mabe, Charles F. Emery, Tereza Martinu, Philip T. Diaz, Michael Babyak, Karen Welty-Wolf, and Scott Palmer. “Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial.” Psychosom Med 78, no. 2 (2016): 153–62. https://doi.org/10.1097/PSY.0000000000000260.
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  - Fredenburgh, Laura E., Bryan D. Kraft, Dean R. Hess, R Scott Harris, Monroe A. Wolf, Hagir B. Suliman, Victor L. Roggli, et al. “Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.” Am J Physiol Lung Cell Mol Physiol 309, no. 8 (October 15, 2015): L834–46. https://doi.org/10.1152/ajplung.00240.2015.
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  - Pecorella, Shelly R. H., Jennifer V. F. Potter, Anne D. Cherry, Dionne F. Peacher, Karen E. Welty-Wolf, Richard E. Moon, Claude A. Piantadosi, and Hagir B. Suliman. “The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle.” Am J Physiol Lung Cell Mol Physiol 309, no. 8 (October 15, 2015): L857–71. https://doi.org/10.1152/ajplung.00104.2015.
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  - Dalli, Jesmond, Bryan D. Kraft, Romain A. Colas, Masakazu Shinohara, Laura E. Fredenburgh, Dean R. Hess, Nan Chiang, et al. “The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide.” Am J Respir Cell Mol Biol 53, no. 3 (September 2015): 314–25. https://doi.org/10.1165/rcmb.2014-0299OC.
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  - Durheim, Michael T., Patrick J. Smith, Michael A. Babyak, Stephanie K. Mabe, Tereza Martinu, Karen E. Welty-Wolf, Charles F. Emery, Scott M. Palmer, and James A. Blumenthal. “Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group.” Ann Am Thorac Soc 12, no. 3 (March 2015): 349–56. https://doi.org/10.1513/AnnalsATS.201408-365OC.
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  - Blumenthal, James A., Charles F. Emery, Patrick J. Smith, Francis J. Keefe, Karen Welty-Wolf, Stephanie Mabe, Tereza Martinu, et al. “The effects of a telehealth coping skills intervention on outcomes in chronic obstructive pulmonary disease: primary results from the INSPIRE-II study.” Psychosom Med 76, no. 8 (October 2014): 581–92. https://doi.org/10.1097/PSY.0000000000000101.
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  - Kraft, Bryan D., Claude A. Piantadosi, Ashlee M. Benjamin, Joseph E. Lucas, Aimee K. Zaas, Marisol Betancourt-Quiroz, Christopher W. Woods, et al. “Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates.” Am J Respir Cell Mol Biol 50, no. 5 (May 2014): 995–1004. https://doi.org/10.1165/rcmb.2013-0340OC.
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  - Bartz, Raquel R., Ping Fu, Hagir B. Suliman, Stephen D. Crowley, Nancy Chou MacGarvey, Karen Welty-Wolf, and Claude A. Piantadosi. “Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice.” Plos One 9, no. 7 (2014): e100912. https://doi.org/10.1371/journal.pone.0100912.
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  - Doyle, Todd, Scott Palmer, Julie Johnson, Michael A. Babyak, Patrick Smith, Stephanie Mabe, Karen Welty-Wolf, Tereza Martinu, and James A. Blumenthal. “Association of anxiety and depression with pulmonary-specific symptoms in chronic obstructive pulmonary disease.” Int J Psychiatry Med 45, no. 2 (2013): 189–202. https://doi.org/10.2190/PM.45.2.g.
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  - Athale, Janhavi, Allison Ulrich, Nancy Chou MacGarvey, Raquel R. Bartz, Karen E. Welty-Wolf, Hagir B. Suliman, and Claude A. Piantadosi. “Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.” Free Radic Biol Med 53, no. 8 (October 15, 2012): 1584–94. https://doi.org/10.1016/j.freeradbiomed.2012.08.009.
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  - Piantadosi, Claude A., Raquel R. Bartz, Martha S. Carraway, Andrew J. Ghio, Timothy J. McMahon, David M. Murdoch, Victor L. Roggli, et al. “The opprobrium of Big Tobacco.” Am J Respir Crit Care Med 185, no. 9 (May 1, 2012): 1030. https://doi.org/10.1164/ajrccm.185.9.1030.
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  - MacGarvey, Nancy Chou, Hagir B. Suliman, Raquel R. Bartz, Ping Fu, Crystal M. Withers, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis.” Am J Respir Crit Care Med 185, no. 8 (April 15, 2012): 851–61. https://doi.org/10.1164/rccm.201106-1152OC.
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  - Piantadosi, Claude A., Crystal M. Withers, Raquel R. Bartz, Nancy Chou MacGarvey, Ping Fu, Timothy E. Sweeney, Karen E. Welty-Wolf, and Hagir B. Suliman. “Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression.” J Biol Chem 286, no. 18 (May 6, 2011): 16374–85. https://doi.org/10.1074/jbc.M110.207738.
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  - Bartz, Raquel R., Hagir B. Suliman, Ping Fu, Karen Welty-Wolf, Martha Sue Carraway, Nancy Chou MacGarvey, Crystal M. Withers, Timothy E. Sweeney, and Claude A. Piantadosi. “Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice.” Am J Respir Crit Care Med 183, no. 2 (January 15, 2011): 226–33. https://doi.org/10.1164/rccm.200911-1709OC.
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  - Sweeney, Timothy E., Hagir B. Suliman, John W. Hollingsworth, Karen E. Welty-Wolf, and Claude A. Piantadosi. “A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.” Plos One 6, no. 9 (2011): e25249. https://doi.org/10.1371/journal.pone.0025249.
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  - Suliman, Hagir B., Abdelwahid Babiker, Crystal M. Withers, Timothy E. Sweeney, Martha S. Carraway, Lynn G. Tatro, Raquel R. Bartz, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice.” Free Radic Biol Med 48, no. 5 (March 1, 2010): 736–46. https://doi.org/10.1016/j.freeradbiomed.2009.12.019.
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  - Reynolds, Crystal M., Hagir B. Suliman, John W. Hollingsworth, Karen E. Welty-Wolf, Martha Sue Carraway, and Claude A. Piantadosi. “Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia.” Free Radic Biol Med 46, no. 5 (March 1, 2009): 564–72. https://doi.org/10.1016/j.freeradbiomed.2008.11.007.
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  - Reddy, Anita J., Christopher W. Woods, and Karen E. Welty-Wolf. “Eastern equine encephalitis leading to multi-organ failure and sepsis.” J Clin Virol 42, no. 4 (August 2008): 418–21. https://doi.org/10.1016/j.jcv.2008.03.008.
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  - Carraway, Martha S., Hagir B. Suliman, Corrine Kliment, Karen E. Welty-Wolf, Tim D. Oury, and Claude A. Piantadosi. “Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis.” Antioxid Redox Signal 10, no. 2 (February 2008): 269–75. https://doi.org/10.1089/ars.2007.1910.
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  - Suliman, Hagir B., Martha Sue Carraway, Abdelwahid S. Ali, Chrystal M. Reynolds, Karen E. Welty-Wolf, and Claude A. Piantadosi. “The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy.” J Clin Invest 117, no. 12 (December 2007): 3730–41. https://doi.org/10.1172/JCI32967.
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  - Haden, Douglas W., Hagir B. Suliman, Martha Sue Carraway, Karen E. Welty-Wolf, Abdelwahid S. Ali, Hiroshi Shitara, Hiromichi Yonekawa, and Claude A. Piantadosi. “Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis.” Am J Respir Crit Care Med 176, no. 8 (October 15, 2007): 768–77. https://doi.org/10.1164/rccm.200701-161OC.
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  - Demchenko, Ivan T., Karen E. Welty-Wolf, Barry W. Allen, and Claude A. Piantadosi. “Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide.” Am J Physiol Lung Cell Mol Physiol 293, no. 1 (July 2007): L229–38. https://doi.org/10.1152/ajplung.00450.2006.
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  - Ware, Lorraine B., Eric Camerer, Karen Welty-Wolf, Marcus J. Schultz, and Michael A. Matthay. “Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.” Am J Physiol Lung Cell Mol Physiol 291, no. 3 (September 2006): L307–11. https://doi.org/10.1152/ajplung.00157.2006.
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  - Roggli, Victor L., Claude A. Piantadosi, Neil R. MacIntyre, Stephen L. Young, Peter S. Kussin, Mark P. Steele, Martha Sue Carraway, et al. “Physician subsidies for tobacco advertising.” Am J Respir Crit Care Med 173, no. 2 (January 15, 2006): 246. https://doi.org/10.1164/ajrccm.173.2.246.
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  - Welty-Wolf, Karen E., Martha S. Carraway, Thomas L. Ortel, Andrew J. Ghio, Steven Idell, Jack Egan, Xiaoyun Zhu, Jin-an Jiao, Hing C. Wong, and Claude A. Piantadosi. “Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure.” Am J Physiol Lung Cell Mol Physiol 290, no. 1 (January 2006): L21–31. https://doi.org/10.1152/ajplung.00155.2005.
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  - Suliman, Hagir B., Karen E. Welty-Wolf, Martha Sue Carraway, David A. Schwartz, John W. Hollingsworth, and Claude A. Piantadosi. “Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli.” Faseb J 19, no. 11 (September 2005): 1531–33. https://doi.org/10.1096/fj.04-3500fje.
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  - Suliman, Hagir B., Karen E. Welty-Wolf, Marthasue Carraway, Lynn Tatro, and Claude A. Piantadosi. “Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis.” Cardiovasc Res 64, no. 2 (November 1, 2004): 279–88. https://doi.org/10.1016/j.cardiores.2004.07.005.
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  - Suliman, Hagir B., Martha S. Carraway, Karen E. Welty-Wolf, A Richard Whorton, and Claude A. Piantadosi. “Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1.” J Biol Chem 278, no. 42 (October 17, 2003): 41510–18. https://doi.org/10.1074/jbc.M304719200.
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  - Carraway, Martha Sue, Karen E. Welty-Wolf, Debra L. Miller, Thomas L. Ortel, Steven Idell, Andrew J. Ghio, Lars C. Petersen, and Claude A. Piantadosi. “Blockade of tissue factor: treatment for organ injury in established sepsis.” Am J Respir Crit Care Med 167, no. 9 (May 1, 2003): 1200–1209. https://doi.org/10.1164/rccm.200204-287OC.
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  - Welty-Wolf, Karen E., Martha S. Carraway, Thomas L. Ortel, and Claude A. Piantadosi. “Coagulation and inflammation in acute lung injury.” Thromb Haemost 88, no. 1 (July 2002): 17–25.
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  - Miller, Debra L., Karen Welty-Wolf, Martha Sue Carraway, Mirella Ezban, Andrew Ghio, Hagir Suliman, and Claude A. Piantadosi. “Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide.” Am J Respir Cell Mol Biol 26, no. 6 (June 2002): 650–58. https://doi.org/10.1165/ajrcmb.26.6.4688.
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  - Welty-Wolf, K. E., M. S. Carraway, D. L. Miller, T. L. Ortel, M. Ezban, A. J. Ghio, S. Idell, and C. A. Piantadosi. “Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons.” Am J Respir Crit Care Med 164, no. 10 Pt 1 (November 15, 2001): 1988–96. https://doi.org/10.1164/ajrccm.164.10.2105027.
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  - Welty-Wolf, K. E., M. S. Carraway, S. Idell, T. L. Ortel, M. Ezban, and C. A. Piantadosi. “Tissue factor in experimental acute lung injury.” Semin Hematol 38, no. 4 Suppl 12 (October 2001): 35–38. https://doi.org/10.1053/shem.2001.29505.
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  - Auten, R. L., S. N. Mason, D. T. Tanaka, K. Welty-Wolf, and M. H. Whorton. “Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats.” Am J Physiol Lung Cell Mol Physiol 281, no. 2 (August 2001): L336–44. https://doi.org/10.1152/ajplung.2001.281.2.L336.
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  - Welty-Wolf, K. E., M. S. Carraway, Y. C. Huang, S. G. Simonson, S. P. Kantrow, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis.” Am J Respir Crit Care Med 163, no. 3 Pt 1 (March 2001): 665–73. https://doi.org/10.1164/ajrccm.163.3.2004191.
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  - Welty-Wolf, K. E., M. S. Carraway, S. Idell, T. L. Ortel, M. Ezban, and C. A. Piantadosi. “Tissue factor in experimental acute lung injury.” Seminars in Hematology 38, no. 4 SUPPL. 12 (January 1, 2001): 35–38. https://doi.org/10.1016/s0037-1963(01)90145-3.
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  - Welty-Wolf, K. E., M. S. Carraway, A. Ghio, S. P. Kantrow, Y. C. Huang, and C. A. Piantadosi. “Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy.” Shock 13, no. 5 (May 2000): 404–9. https://doi.org/10.1097/00024382-200005000-00010.
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  - Welty-Wolf, K. E., and C. A. Piantadosi. “LPS amplifies or attenuates endotoxin-induced acute lung injury in mice depending on route of priming exposure.” American Journal of Respiratory and Critical Care Medicine 159, no. 3 (March 1, 1999): A599–A599.
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  - Welty-Wolf, K. E., M. S. Carraway, Y. C. Huang, S. G. Simonson, S. P. Kantrow, and C. A. Piantadosi. “Bacterial priming increases lung injury in gram-negative sepsis.” Am J Respir Crit Care Med 158, no. 2 (August 1998): 610–19. https://doi.org/10.1164/ajrccm.158.2.9704064.
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  - Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons.” Am J Respir Crit Care Med 157, no. 3 Pt 1 (March 1998): 938–49. https://doi.org/10.1164/ajrccm.157.3.9707129.
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  - Simonson, S. G., K. E. Welty-Wolf, Y. C. Huang, D. E. Taylor, S. P. Kantrow, M. S. Carraway, J. D. Crapo, and C. A. Piantadosi. “Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry.” J Appl Physiol (1985) 83, no. 2 (August 1997): 550–58. https://doi.org/10.1152/jappl.1997.83.2.550.
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  - Welty-Wolf, K. E., S. G. Simonson, Y. C. Huang, S. P. Kantrow, M. S. Carraway, L. Y. Chang, J. D. Crapo, and C. A. Piantadosi. “Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis.” J Appl Physiol (1985) 83, no. 2 (August 1997): 559–68. https://doi.org/10.1152/jappl.1997.83.2.559.
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  - Simonson, S. G., Y. C. Huang, P. J. Fracica, K. E. Welty-Wolf, R. E. Moon, S. L. Young, and C. A. Piantadosi. “Changes in the lung after prolonged positive pressure ventilation in normal baboons.” J Crit Care 12, no. 2 (June 1997): 72–82. https://doi.org/10.1016/s0883-9441(97)90004-6.
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  - Huang, Y. C., P. J. Fracica, S. G. Simonson, J. D. Crapo, S. L. Young, K. E. Welty-Wolf, R. E. Moon, and C. A. Piantadosi. “VA/Q abnormalities during gram negative sepsis.” Respir Physiol 105, no. 1–2 (August 1996): 109–21. https://doi.org/10.1016/0034-5687(96)00039-4.
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  - Welty-Wolf, K. E., S. G. Simonson, Y. C. Huang, P. J. Fracica, J. W. Patterson, and C. A. Piantadosi. “Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis.” Shock 5, no. 5 (May 1996): 378–84. https://doi.org/10.1097/00024382-199605000-00011.
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  - Kanj, S. S., K. Welty-Wolf, J. Madden, V. Tapson, M. A. Baz, R. D. Davis, and J. R. Perfect. “Fungal infections in lung and heart-lung transplant recipients. Report of 9 cases and review of the literature.” Medicine (Baltimore) 75, no. 3 (May 1996): 142–56. https://doi.org/10.1097/00005792-199605000-00004.
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  - Piantadosi, C. A., P. J. Fracica, F. G. Duhaylongsod, Y. C. Huang, K. E. Welty-Wolf, J. D. Crapo, and S. L. Young. “Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis.” J Appl Physiol (1985) 78, no. 5 (May 1995): 1823–31. https://doi.org/10.1152/jappl.1995.78.5.1823.
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  - Welty-Wolf, K. “Pulmonary Function: A Guide for Clinicians.” Bmj 309, no. 6967 (December 3, 1994): 1521. https://doi.org/10.1136/bmj.309.6967.1521.
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  - Simonson, S. G., K. Welty-Wolf, Y. T. Huang, J. A. Griebel, M. S. Caplan, P. J. Fracica, and C. A. Piantadosi. “Altered mitochondrial redox responses in gram negative septic shock in primates.” Circ Shock 43, no. 1 (May 1994): 34–43.
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  - Kim, J. H., R. A. Cooper, K. E. Welty-Wolf, L. J. Harrell, P. Zwadyk, and M. E. Klotman. “Pseudomonas putrefaciens bacteremia.” Rev Infect Dis 11, no. 1 (1989): 97–104.
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- Conference Papers
  - Kaur, A., A. Reihman, R. A. Pleasants, J. Boggan, L. Howard, R. Kundich, K. E. Welty-Wolf, A. Bedoya, and R. M. Tighe. “Assessing the Frequency of Pulmonary Function Testing in Veterans with Idiopathic Pulmonary Fibrosis at Time of Diagnosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Chen, L., B. D. Kraft, V. L. Roggli, H. Suliman, C. A. Piantadosi, and K. E. Welty-Wolf. “Blood Filtration Using Dialysis-Like Therapy Attenuates Organ Injury in Nonhuman Primates with Severe Streptococcus Pneumoniae Sepsis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
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  - Chen, L., B. D. Kraft, V. L. Roggli, H. B. Suliman, C. A. Piantadosi, and K. E. Welty-Wolf. “Severe Pneumococcal Pneumonia Causes Cardiac and Skeletal Muscle Injuries in Baboons.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Pleasants, R. A., A. Bedoya, R. Kundich, J. Boggan, A. Reihman, D. Seaman, L. Howard, K. E. Welty-Wolf, and R. M. Tighe. “Characteristics of Connective Tissue Related Interstitial Lung Disease in the Mid- Atlantic Veterans Affairs Regional Network.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Reihman, A., A. Bedoya, R. A. Pleasants, J. Boggan, L. Howard, R. Kundich, K. E. Welty-Wolf, and R. M. Tighe. “Initial Pulmonary Function Patterns Define Clinical Characteristics in Veterans Affairs Cohort with Interstitial Lung Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Bedoya, A. D., R. Pleasants, J. Boggan, D. Seaman, L. Howard, A. Reihman, K. Welty-Wolf, and R. M. Tighe. “Characteristics Of Interstitial Lung Disease In The Mid-Atlantic Veterans Affairs Regional Network.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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  - Kraft, B., C. A. Piantadosi, H. B. Suliman, G. S. Ginsburg, R. R. Bartz, A. Zaas, M. Betancourt, and K. E. Welty-Wolf. “Pneumococcal Pneumonia And Sepsis In Baboons Mirrors The Human Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.
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  - Piantadosi, Claude A., Crystal M. Withers, Raquel R. Bartz, Nancy C. MacGarvey, Timothy E. Sweeney, Karen E. Welty-Wolf, and Hagir B. Suliman. “Redox Activation of Mitochondrial Biogenesis by Heme Oxygenase-1 Exerts Counter-regulatory Control over NF-kB-dependent Cytokine Production.” In Faseb Journal, Vol. 25. FEDERATION AMER SOC EXP BIOL, 2011.
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  - Reynolds, Crystal M., Hagir B. Suliman, Matha Sue Carraway, John W. Hollingsworth, Kern E. Welty-Wolf, and Claude A. Piantadosi. “Nitric oxide and toll-like receptor 4 are required for cardiac mitochondrial biogenesis after endotoxemia.” In Free Radical Biology and Medicine, 43:S144–S144. ELSEVIER SCIENCE INC, 2007.
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  - Babiker, Abdelwahid Saeed, Hagir B. Suliman, Martha Sue Carraway, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Mitochondrial biogenesis in sepsis: a role for inducible nitric oxide synthase.” In Free Radical Biology and Medicine, 41:S47–S47. ELSEVIER SCIENCE INC, 2006.
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  - Suliman, Hagir B., Martha Sue Carraway, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Carbon monoxide protects against mitochondrial damage in doxorubicin-induced myocardial dysfunction.” In Free Radical Biology and Medicine, 41:S152–S152. ELSEVIER SCIENCE INC, 2006.
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  - Piantadosi, Claude A., Martha Sue Carraway, Karen E. Welty-Wolf, and Hagir B. Suliman. “OXIDATIVE DAMAGE OF MITOCHONDRIA AND MITOCHONDRIAL DNA IN SEPSIS.” In Shock, 21:57–57. Ovid Technologies (Wolters Kluwer Health), 2004. https://doi.org/10.1097/00024382-200403001-00228.
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  - Miller, D. L., K. E. Welty-Wolf, M. S. Carraway, C. A. Piantadosi, and L. C. Petersen. “Competitive inhibition of Factor VIIa regulates bronchoalveolar lavage cell activation after intratracheal lipopolysaccharide.” In Faseb Journal, 17:C71–C71. FEDERATION AMER SOC EXP BIOL, 2003.
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