Karen Elizabeth Welty-Wolf

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Current Appointments & Affiliations

Professor Emeritus of Medicine · 2025 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine

Recent Publications

Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons.

Journal Article Animal Model Exp Med · October 2025 BACKGROUND: Bacterial pneumonia remains a leading cause of morbidity and mortality worldwide despite the widespread availability of antibiotics. Novel pneumonia therapies and biomarkers are urgently needed to improve outcomes and advance personalized thera ... Full text Link to item Cite

Retraction Notice to: Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis.

Journal Article iScience · June 20, 2025 [This retracts the article DOI: 10.1016/j.isci.2021.103535.]. ... Full text Link to item Cite

Nondental Invasive Procedures and Risk of Infective Endocarditis: Time for a Revisit: A Science Advisory From the American Heart Association.

Journal Article Circulation · November 7, 2023 There have been no published prospective randomized clinical trials that have: (1) established an association between invasive dental and nondental invasive procedures and risk of infective endocarditis; or (2) defined the efficacy and safety of antibiotic ... Full text Link to item Cite

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Education, Training & Certifications

Duke University · 1986 M.D.

Karen Elizabeth Welty-Wolf

Overview

Current Appointments & Affiliations

Recent Publications

Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons.

Retraction Notice to: Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis.

Nondental Invasive Procedures and Risk of Infective Endocarditis: Time for a Revisit: A Science Advisory From the American Heart Association.

Recent Grants

A Phase II Study of Inhaled Carbon Monoxide for the Treatment of ARDS

A Phase 1b Study of Inhaled CO for the Treatment of Sepsis-Induced ARDS

Interdisciplinary Training Program in Lung Disease

Education, Training & Certifications