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Branched-chain amino acids in cardiovascular disease.

Publication ,  Journal Article
McGarrah, RW; White, PJ
Published in: Nat Rev Cardiol
February 2023

Research conducted in the past 15 years has yielded crucial insights that are reshaping our understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism and the molecular mechanisms underlying the close relationship between BCAA homeostasis and cardiovascular health. The rapidly evolving literature paints a complex picture, in which numerous tissue-specific and disease-specific modes of BCAA regulation initiate a diverse set of molecular mechanisms that connect changes in BCAA homeostasis to the pathogenesis of cardiovascular diseases, including myocardial infarction, ischaemia-reperfusion injury, atherosclerosis, hypertension and heart failure. In this Review, we outline the current understanding of the major factors regulating BCAA abundance and metabolic fate, highlight molecular mechanisms connecting impaired BCAA homeostasis to cardiovascular disease, discuss the epidemiological evidence connecting BCAAs with various cardiovascular disease states and identify current knowledge gaps requiring further investigation.

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Published In

Nat Rev Cardiol

DOI

EISSN

1759-5010

Publication Date

February 2023

Volume

20

Issue

2

Start / End Page

77 / 89

Location

England

Related Subject Headings

  • Myocardial Infarction
  • Humans
  • Heart Failure
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Amino Acids, Branched-Chain
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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McGarrah, R. W., & White, P. J. (2023). Branched-chain amino acids in cardiovascular disease. Nat Rev Cardiol, 20(2), 77–89. https://doi.org/10.1038/s41569-022-00760-3
McGarrah, Robert W., and Phillip J. White. “Branched-chain amino acids in cardiovascular disease.Nat Rev Cardiol 20, no. 2 (February 2023): 77–89. https://doi.org/10.1038/s41569-022-00760-3.
McGarrah RW, White PJ. Branched-chain amino acids in cardiovascular disease. Nat Rev Cardiol. 2023 Feb;20(2):77–89.
McGarrah, Robert W., and Phillip J. White. “Branched-chain amino acids in cardiovascular disease.Nat Rev Cardiol, vol. 20, no. 2, Feb. 2023, pp. 77–89. Pubmed, doi:10.1038/s41569-022-00760-3.
McGarrah RW, White PJ. Branched-chain amino acids in cardiovascular disease. Nat Rev Cardiol. 2023 Feb;20(2):77–89.

Published In

Nat Rev Cardiol

DOI

EISSN

1759-5010

Publication Date

February 2023

Volume

20

Issue

2

Start / End Page

77 / 89

Location

England

Related Subject Headings

  • Myocardial Infarction
  • Humans
  • Heart Failure
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Amino Acids, Branched-Chain
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology