Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Universite Laval (Canada) 2012
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2017 - 2020
• Recognition
• 

  In the News

  • JAN 22, 2019

    Medical Xpress

    Branched-chain amino acids regulate the development and progression of cancer

  • MAY 18, 2018

    DIABETES RESEARCHERS FIND SWITCH FOR FATTY LIVER DISEASE Carbs, Fats and Protein: One molecule to rule them all?

  • APR 6, 2016

    Drop in body temperature linked to aging aggravates manifestations of Alzheimer's disease

  • FEB 2, 2016

    Six researchers each receive $1.625 million in "Pathway to Stop Diabetes®" awards

  • MAY 13, 2014

    Scientists make another breakthrough in finding cure for diabetes
• Expertise
• 

  Subject Headings

  • Fatty Liver
  • Heart Failure
  • Insulin Resistance
  • Metabolism
  • Non-insulin-dependent diabetes
  • Obesity
  • Physiology
• Research
• 

  Selected Grants

  • Mechanisms Connecting Dysregulated Branched-Chain Alpha-Ketoacid Metabolism to Cardiac Dysfunction awarded by National Institutes of Health 2022 - 2027
  • Leveraging glucagon activity to target hepatic steatosis, fibrosis, and inflammation awarded by Merck Sharp & Dohme 2022 - 2024
  • Quantifying Enteric Metabolism of Branched-chain Amino Acids in Relation to Other Dietary and Microbiota Nutrients awarded by National Institutes of Health 2022 - 2024
  • Mechanisms connecting dysregulated BCAA, glucose & lipid metabolism in the pathogenesis of metabolic disease awarded by National Institutes of Health 2019 - 2023
  • Reshaping Liver Branched-Chain Alpha-Keto Acid Metabolism to Prevent Diabetic Cardiomyopathy awarded by American Diabetes Association 2021 - 2022
  • A New Homeostatic Mechanism for Metabolic Control awarded by American Diabetes Association 2016 - 2022
  • Collaborative Study on Biomarkers of Fatty Liver Diseases awarded by Pfizer, Inc. 2017 - 2018
  • Manipulation of BCAA Metabolism for Therapy of Diabetes and its Co-morbidities awarded by Eli Lilly and Company 2017 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • McGarrah, Robert W., and Phillip J. White. “Branched-chain amino acids in cardiovascular disease.” Nat Rev Cardiol 20, no. 2 (February 2023): 77–89. https://doi.org/10.1038/s41569-022-00760-3.
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    • Sargsyan, Ashot, Ludivine Doridot, Sarah A. Hannou, Wenxin Tong, Harini Srinivasan, Rachael Ivison, Ruby Monn, et al. “HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.” Jci Insight 8, no. 1 (January 10, 2023). https://doi.org/10.1172/jci.insight.153740.
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    • Gumus Balikcioglu, Pinar, Catherine Jachthuber Trub, Metin Balikcioglu, Olga Ilkayeva, Phillip J. White, Michael Muehlbauer, James R. Bain, Sarah Armstrong, and Michael Freemark. “Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.” Endocrinol Diabetes Metab 6, no. 1 (January 2023): e388. https://doi.org/10.1002/edm2.388.
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    • Grenier-Larouche, Thomas, Lydia Coulter Kwee, Yann Deleye, Paola Leon-Mimila, Jacquelyn M. Walejko, Robert W. McGarrah, Simon Marceau, et al. “Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity.” Jci Insight 7, no. 15 (August 8, 2022). https://doi.org/10.1172/jci.insight.159204.
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    • Patel, Suraj J., Nan Liu, Sam Piaker, Anton Gulko, Maynara L. Andrade, Frankie D. Heyward, Tyler Sermersheim, et al. “Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.” Sci Transl Med 14, no. 637 (March 23, 2022): eabh3831. https://doi.org/10.1126/scitranslmed.abh3831.
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    • Chandra, Rashmi, Dipendra K. Aryal, Jonathan D. Douros, Rafiq Shahid, Supriya J. Davis, Jonathan E. Campbell, Olga Ilkayeya, et al. “Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.” Plos One 17, no. 6 (2022): e0270329. https://doi.org/10.1371/journal.pone.0270329.
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    • White, Phillip J., Robert W. McGarrah, Mark A. Herman, James R. Bain, Svati H. Shah, and Christopher B. Newgard. “Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.” Mol Metab 52 (October 2021): 101261. https://doi.org/10.1016/j.molmet.2021.101261.
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    • Jachthuber Trub, Catherine, Metin Balikcioglu, Michael Freemark, James Bain, Michael Muehlbauer, Olga Ilkayeva, Phillip J. White, et al. “Impact of lifestyle Intervention on branched-chain amino acid catabolism and insulin sensitivity in adolescents with obesity.” Endocrinol Diabetes Metab 4, no. 3 (July 2021): e00250. https://doi.org/10.1002/edm2.250.
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    • Lee, Jennifer, Archana Vijayakumar, Phillip J. White, Yuping Xu, Olga Ilkayeva, Christopher J. Lynch, Christopher B. Newgard, and Barbara B. Kahn. “BCAA Supplementation in Mice with Diet-induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis.” Endocrinology 162, no. 7 (July 1, 2021). https://doi.org/10.1210/endocr/bqab062.
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    • Choi, Béatrice S-Y, Noëmie Daniel, Vanessa P. Houde, Adia Ouellette, Bruno Marcotte, Thibault V. Varin, Cécile Vors, et al. “Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice.” Nat Commun 12, no. 1 (June 7, 2021): 3377. https://doi.org/10.1038/s41467-021-23782-w.
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    • Yoneshiro, Takeshi, Naoya Kataoka, Jacquelyn M. Walejko, Kenji Ikeda, Zachary Brown, Momoko Yoneshiro, Scott B. Crown, et al. “Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever.” Elife 10 (May 4, 2021). https://doi.org/10.7554/eLife.66865.
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    • Walejko, Jacquelyn M., Bridgette A. Christopher, Scott B. Crown, Guo-Fang Zhang, Adrian Pickar-Oliver, Takeshi Yoneshiro, Matthew W. Foster, et al. “Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart.” Nat Commun 12, no. 1 (March 15, 2021): 1680. https://doi.org/10.1038/s41467-021-21962-2.
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    • White, Phillip J., and Manal F. Abdelmalek. “Insights Into Metabolic Mechanisms and Their Application in the Treatment of NASH.” Clin Liver Dis (Hoboken) 17, no. 1 (January 2021): 29–32. https://doi.org/10.1002/cld.1062.
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    • White, Phillip J., Amanda L. Lapworth, Robert W. McGarrah, Lydia Coulter Kwee, Scott B. Crown, Olga Ilkayeva, Jie An, et al. “Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.” Cell Rep 33, no. 6 (November 10, 2020): 108375. https://doi.org/10.1016/j.celrep.2020.108375.
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    • McGarrah, Robert W., Guo-Fang Zhang, Bridgette A. Christopher, Yann Deleye, Jacquelyn M. Walejko, Stephani Page, Olga Ilkayeva, Phillip J. White, and Christopher B. Newgard. “Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats.” Am J Physiol Endocrinol Metab 318, no. 2 (February 1, 2020): E216–23. https://doi.org/10.1152/ajpendo.00334.2019.
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    • Huang, Rong, Xiaohua Zong, Puviindran Nadesan, Janet L. Huebner, Virginia B. Kraus, James P. White, Phillip J. White, and Gurpreet S. Baht. “Lowering circulating apolipoprotein E levels improves aged bone fracture healing.” Jci Insight 4, no. 18 (September 19, 2019). https://doi.org/10.1172/jci.insight.129144.
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    • Hung, Yu-Han, Matt Kanke, C Lisa Kurtz, Rebecca Cubitt, Rodica P. Bunaciu, Ji Miao, Liye Zhou, et al. “Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice.” Physiol Genomics 51, no. 8 (August 1, 2019): 379–89. https://doi.org/10.1152/physiolgenomics.00037.2019.
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    • Yoneshiro, Takeshi, Qiang Wang, Kazuki Tajima, Mami Matsushita, Hiroko Maki, Kaori Igarashi, Zhipeng Dai, et al. “BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.” Nature 572, no. 7771 (August 2019): 614–19. https://doi.org/10.1038/s41586-019-1503-x.
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    • Ericksen, Russell E., Siew Lan Lim, Eoin McDonnell, Wai Ho Shuen, Maya Vadiveloo, Phillip J. White, Zhaobing Ding, et al. “Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression.” Cell Metab 29, no. 5 (May 7, 2019): 1151-1165.e6. https://doi.org/10.1016/j.cmet.2018.12.020.
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    • White, Phillip J., and Christopher B. Newgard. “Branched-chain amino acids in disease.” Science 363, no. 6427 (February 8, 2019): 582–83. https://doi.org/10.1126/science.aav0558.
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    • Hung, Yu-Han, Matt Kanke, Catherine Lisa Kurtz, Rebecca L. Cubitt, Rodica P. Bunaciu, Liye Zhou, Phillip J. White, et al. “MiR-29 Regulates de novo Lipogenesis in the Liver and Circulating Triglyceride Levels in a Sirt1-Dependent Manner.” Front Physiol 10 (2019): 1367. https://doi.org/10.3389/fphys.2019.01367.
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    • White, Phillip J., Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M. Haldeman, Thomas Grenier-Larouche, et al. “The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.” Cell Metab 27, no. 6 (June 5, 2018): 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015.
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    • Gurley, Jami M., Olga Ilkayeva, Robert M. Jackson, Beth A. Griesel, Phillip White, Satochi Matsuzaki, Rizwan Qaisar, et al. “Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism.” Diabetes 65, no. 12 (December 2016): 3585–97. https://doi.org/10.2337/db16-0709.
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    • Vandal, Milene, Philip J. White, Marine Tournissac, Cyntia Tremblay, Isabelle St-Amour, Janelle Drouin-Ouellet, Melanie Bousquet, et al. “Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease.” Neurobiol Aging 43 (July 2016): 47–57. https://doi.org/10.1016/j.neurobiolaging.2016.03.024.
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    • White, Phillip J., Amanda L. Lapworth, Jie An, Liping Wang, Robert W. McGarrah, Robert D. Stevens, Olga Ilkayeva, et al. “Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export.” Mol Metab 5, no. 7 (July 2016): 538–51. https://doi.org/10.1016/j.molmet.2016.04.006.
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    • Vandal, Milene, Phillip J. White, Geneviève Chevrier, Cyntia Tremblay, Isabelle St-Amour, Emmanuel Planel, Andre Marette, and Frederic Calon. “Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease.” Faseb J 29, no. 10 (October 2015): 4273–84. https://doi.org/10.1096/fj.14-268482.
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    • Glynn, Erin L., Lucy W. Piner, Kim M. Huffman, Cris A. Slentz, Lorraine Elliot-Penry, Hiba AbouAssi, Phillip J. White, et al. “Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.” Diabetologia 58, no. 10 (October 2015): 2324–35. https://doi.org/10.1007/s00125-015-3705-6.
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    • White, P. J., P. L. Mitchell, M. Schwab, J. Trottier, J. X. Kang, O. Barbier, and A. Marette. “Erratum: Transgenic ω -3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins (Metab Clin Exp (2015): 64 (666-676)).” Metabolism: Clinical and Experimental 64, no. 9 (September 1, 2015): E7–8. https://doi.org/10.1016/j.metabol.2015.04.007.
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    • White, Phillip J., Patricia L. Mitchell, Michael Schwab, Jocelyn Trottier, Jing X. Kang, Olivier Barbier, and André Marette. “Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins.” Metabolism 64, no. 6 (June 2015): 666–76. https://doi.org/10.1016/j.metabol.2015.01.017.
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    • Vandal, Milene, Phillip J. White, Cyntia Tremblay, Isabelle St-Amour, Geneviève Chevrier, Vincent Emond, Dominique Lefrançois, et al. “Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease.” Diabetes 63, no. 12 (December 2014): 4291–4301. https://doi.org/10.2337/db14-0375.
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    • Shin, Andrew C., Martin Fasshauer, Nika Filatova, Linus A. Grundell, Elizabeth Zielinski, Jian-Ying Zhou, Thomas Scherer, et al. “Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.” Cell Metab 20, no. 5 (November 4, 2014): 898–909. https://doi.org/10.1016/j.cmet.2014.09.003.
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    • White, Phillip J., Philippe St-Pierre, Alexandre Charbonneau, Patricia L. Mitchell, Emmanuelle St-Amand, Bruno Marcotte, and André Marette. “Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis.” Nat Med 20, no. 6 (June 2014): 664–69. https://doi.org/10.1038/nm.3549.
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    • White, Phillip J., and André Marette. “Potential role of omega-3-derived resolution mediators in metabolic inflammation.” Immunol Cell Biol 92, no. 4 (April 2014): 324–30. https://doi.org/10.1038/icb.2013.112.
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    • Turner, N., G. M. Kowalski, S. J. Leslie, S. Risis, C. Yang, R. S. Lee-Young, J. R. Babb, et al. “Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding.” Diabetologia 56, no. 7 (July 2013): 1638–48. https://doi.org/10.1007/s00125-013-2913-1.
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    • Vandal, Milene, Cyntia Tremblay, Isabelle St‐Amour, Janelle Drouin‐Ouellet, Phillip White, Melanie Bousquet, Emmanuel Planel, André Marette, and Frederic Calon. “P2–417: A self‐amplifying loop between thermogenesis and Alzheimer's disease neuropathology in 3xTg‐AD mice.” Alzheimer’S &Amp; Dementia 9, no. 4S_Part_13 (July 2013). https://doi.org/10.1016/j.jalz.2013.05.1067.
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    • Vandal, Milene, Phillip White, Cyntia Tremblay, Janelle Drouin‐Ouellet, Melanie Bousquet, Emmanuel Planel, Andre Marette, and Frederic Calon. “O1‐02‐03: Metabolic defects in the 3xTg‐AD model of Alzheimer's disease are further enhanced by diet‐induced obesity.” Alzheimer’S &Amp; Dementia 8, no. 4S_Part_2 (July 2012). https://doi.org/10.1016/j.jalz.2012.05.210.
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    • Pilon, Geneviève, Jérôme Ruzzin, Laurie-Eve Rioux, Charles Lavigne, Phillip J. White, Livar Frøyland, Hélène Jacques, Piotr Bryl, Lucie Beaulieu, and André Marette. “Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat-fed rats.” Metabolism 60, no. 8 (August 2011): 1122–30. https://doi.org/10.1016/j.metabol.2010.12.005.
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    • Pilon, Geneviève, Alexandre Charbonneau, Phillip J. White, Patrice Dallaire, Mylène Perreault, Sonia Kapur, and André Marette. “Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle.” Plos One 5, no. 12 (December 28, 2010): e15912. https://doi.org/10.1371/journal.pone.0015912.
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    • White, Phillip J., Alexandre Charbonneau, Gregory J. Cooney, and André Marette. “Nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species.” Am J Physiol Endocrinol Metab 299, no. 6 (December 2010): E868–78. https://doi.org/10.1152/ajpendo.00510.2010.
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    • White, Phillip J., Makoto Arita, Ryo Taguchi, Jing X. Kang, and André Marette. “Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice.” Diabetes 59, no. 12 (December 2010): 3066–73. https://doi.org/10.2337/db10-0054.
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    • Gingras, Andrée-Anne, Phillip James White, P Yvan Chouinard, Pierre Julien, Teresa A. Davis, Luce Dombrowski, Yvon Couture, et al. “Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity.” J Physiol 579, no. Pt 1 (February 15, 2007): 269–84. https://doi.org/10.1113/jphysiol.2006.121079.
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    • White, P. J., and A. Marette. “Is omega-3 key to unlocking inflammation in obesity?” Diabetologia 49, no. 9 (September 2006): 1999–2001. https://doi.org/10.1007/s00125-006-0346-9.
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  • Preprints

    • Abdi, Khadar, Ramona Rodriguiz, William Wetsel, Michelle Arlotto, Robert McGarrah, and Phillip White. “Nervous system reduction in branched-chain amino acid metabolism disrupts hippocampal neurogenesis and memory.” BioRxiv, June 13, 2022. https://doi.org/10.1101/2022.06.10.495711.
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    • Hung, Yu-Han, Ramja Sritharan, Marie-Claude Vohl, Olga Ilkayeva, Laurent Biertho, André Tchernof, Phillip White, and Praveen Sethupathy. “Super-enhancer signature reveals key mechanisms associated with resistance to non-alcoholic steatohepatitis in humans with obesity.” BioRxiv, August 21, 2021. https://doi.org/10.1101/2021.08.20.457162.
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• Scholarly, Clinical, & Service Activities
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  Service to the Profession

  • Concept review panel. Department of Medicine, Research Development Council. 2019  2019
  • Editorial Board Member. Diabetes. American Diabetes Association. 2019  2019
  • Research Grant Review Committee. American Diabetes Association. 2019  2019

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