Phillip James White | Scholars@Duke

Phillip James White
Assistant Professor in Medicine

Phillip White is an Assistant Professor in the Department of Medicine, Division of Endocrinology, Metabolism and Nutrition. Phillip Co-Leads the White-McGarrah Lab with Robert McGarrah at the Duke Molecular Physiology Institue. Projects in the White-McGarrah Lab relate to the integrative physiology of metabolism with an emphasis on liver and heart function and the metabolic crosstalk that exists between these two vital organs.

Current Research Interests

Liver Related Projects:

Mechanisms of hepatic lipogenesis and gluconeogenesis.
Determinants of NAFLD status in Bariatric Surgery Patients.
Defining the impact of heart failure on liver metabolism.

Heart Related Projects:

Metabolic determinants of cardiac function.
Role of hepatic metabolic alterations in heart failure pathogenesis.
Functional significance of acylcarnitine associations with cardiac outcomes.

Current Appointments & Affiliations

Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2017
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2017

Contact Information

Background
Education, Training, & Certifications
- Ph.D., Universite Laval (Canada) 2012
Recognition
In the News
- JAN 22, 2019 Medical Xpress
  
  Branched-chain amino acids regulate the development and progression of cancer
- MAY 18, 2018
  
  DIABETES RESEARCHERS FIND SWITCH FOR FATTY LIVER DISEASE Carbs, Fats and Protein: One molecule to rule them all?
- APR 6, 2016
  
  Drop in body temperature linked to aging aggravates manifestations of Alzheimer's disease
- FEB 2, 2016
  
  Six researchers each receive $1.625 million in "Pathway to Stop Diabetes®" awards
- MAY 13, 2014
  
  Scientists make another breakthrough in finding cure for diabetes
Expertise
Subject Headings
Research
Selected Grants
- A New Homeostatic Mechanism for Metabolic Control awarded by American Diabetes Association 2016 - 2019
- Collaborative Study on Biomarkers of Fatty Liver Diseases awarded by Pfizer, Inc. 2017 - 2018
- Eli Lilly Collaboration awarded by Eli Lilly and Company 2017 - 2018
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ericksen, RE, Lim, SL, McDonnell, E, Shuen, WH, Vadiveloo, M, White, PJ, Ding, Z, Kwok, R, Lee, P, Radda, GK, Toh, HC, Hirschey, MD, and Han, W. "Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression." Cell Metabolism 29, no. 5 (May 2019): 1151-1165.e6. Full Text
  - White, PJ, and Newgard, CB. "Branched-chain amino acids in disease." Science (New York, N.Y.) 363, no. 6427 (February 2019): 582-583. Full Text
  - White, PJ, McGarrah, RW, Grimsrud, PA, Tso, S-C, Yang, W-H, Haldeman, JM, Grenier-Larouche, T, An, J, Lapworth, AL, Astapova, I, Hannou, SA, George, T, Arlotto, M, Olson, LB, Lai, M, Zhang, G-F, Ilkayeva, O, Herman, MA, Wynn, RM, Chuang, DT, and Newgard, CB. "The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase." Cell Metabolism 27, no. 6 (June 2018): 1281-1293.e7. Full Text
  - Gurley, JM, Ilkayeva, O, Jackson, RM, Griesel, BA, White, P, Matsuzaki, S, Qaisar, R, Van Remmen, H, Humphries, KM, Newgard, CB, and Olson, AL. "Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism." Diabetes 65, no. 12 (December 2016): 3585-3597. Full Text
  - Vandal, M, White, PJ, Tournissac, M, Tremblay, C, St-Amour, I, Drouin-Ouellet, J, Bousquet, M, Traversy, M-T, Planel, E, Marette, A, and Calon, F. "Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease." Neurobiology of Aging 43 (July 2016): 47-57. Full Text
  - White, PJ, Lapworth, AL, An, J, Wang, L, McGarrah, RW, Stevens, RD, Ilkayeva, O, George, T, Muehlbauer, MJ, Bain, JR, Trimmer, JK, Brosnan, MJ, Rolph, TP, and Newgard, CB. "Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export." Molecular Metabolism 5, no. 7 (July 2016): 538-551. Full Text
  - Glynn, EL, Piner, LW, Huffman, KM, Slentz, CA, Elliot-Penry, L, AbouAssi, H, White, PJ, Bain, JR, Muehlbauer, MJ, Ilkayeva, OR, Stevens, RD, Porter Starr, KN, Bales, CW, Volpi, E, Brosnan, MJ, Trimmer, JK, Rolph, TP, Newgard, CB, and Kraus, WE. "Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans." Diabetologia 58, no. 10 (October 2015): 2324-2335. Full Text
  - Vandal, M, White, PJ, Chevrier, G, Tremblay, C, St-Amour, I, Planel, E, Marette, A, and Calon, F. "Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 29, no. 10 (October 2015): 4273-4284. Full Text
  - White, PJ, Mitchell, PL, Schwab, M, Trottier, J, Kang, JX, Barbier, O, and Marette, A. "Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins." Metabolism: Clinical and Experimental 64, no. 6 (June 2015): 666-676. Full Text
  - White, PJ, Mitchell, PL, Schwab, M, Trottier, J, Kang, JX, Barbier, O, and Marette, A. "Erratum: Transgenic ω -3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins (Metab Clin Exp (2015): 64 (666-676))." Metabolism: Clinical and Experimental 64, no. 9 (January 1, 2015): E7-E8. Full Text
  - Vandal, M, White, PJ, Tremblay, C, St-Amour, I, Chevrier, G, Emond, V, Lefrançois, D, Virgili, J, Planel, E, Giguere, Y, Marette, A, and Calon, F. "Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease." Diabetes 63, no. 12 (December 2014): 4291-4301. Full Text
  - Shin, AC, Fasshauer, M, Filatova, N, Grundell, LA, Zielinski, E, Zhou, J-Y, Scherer, T, Lindtner, C, White, PJ, Lapworth, AL, Ilkayeva, O, Knippschild, U, Wolf, AM, Scheja, L, Grove, KL, Smith, RD, Qian, W-J, Lynch, CJ, Newgard, CB, and Buettner, C. "Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism." Cell Metabolism 20, no. 5 (November 2014): 898-909. Full Text
  - White, PJ, St-Pierre, P, Charbonneau, A, Mitchell, PL, St-Amand, E, Marcotte, B, and Marette, A. "Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis." Nature Medicine 20, no. 6 (June 2014): 664-669. Full Text
  - White, PJ, and Marette, A. "Potential role of omega-3-derived resolution mediators in metabolic inflammation." Immunology and Cell Biology 92, no. 4 (April 2014): 324-330. (Review) Full Text
  - Shin, AC, Fasshauer, M, Filatova, N, Grundell, LA, Zielinski, E, Zhou, JY, Scherer, T, Lindtner, C, White, PJ, Lapworth, AL, Ilkayeva, O, Knippschild, U, Wolf, AM, Scheja, L, Grove, KL, Smith, RD, Qian, WJ, Lynch, CJ, Newgard, CB, and Buettner, C. "Brain insulin lowers circulating bcaa levels by inducing hepatic bcaa catabolism." Cell Metabolism 20, no. 5 (January 1, 2014): 898-909. Full Text
  - Turner, N, Kowalski, GM, Leslie, SJ, Risis, S, Yang, C, Lee-Young, RS, Babb, JR, Meikle, PJ, Lancaster, GI, Henstridge, DC, White, PJ, Kraegen, EW, Marette, A, Cooney, GJ, Febbraio, MA, and Bruce, CR. "Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding." Diabetologia 56, no. 7 (July 2013): 1638-1648. Full Text
  - Pilon, G, Ruzzin, J, Rioux, L-E, Lavigne, C, White, PJ, Frøyland, L, Jacques, H, Bryl, P, Beaulieu, L, and Marette, A. "Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat-fed rats." Metabolism: Clinical and Experimental 60, no. 8 (August 2011): 1122-1130. Full Text
  - Pilon, G, Charbonneau, A, White, PJ, Dallaire, P, Perreault, M, Kapur, S, and Marette, A. "Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle." Plos One 5, no. 12 (December 28, 2011): e15912-null. Full Text
  - White, PJ, Arita, M, Taguchi, R, Kang, JX, and Marette, A. "Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice." Diabetes 59, no. 12 (December 2010): 3066-3073. Full Text
  - White, PJ, Charbonneau, A, Cooney, GJ, and Marette, A. "Nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species." American Journal of Physiology. Endocrinology and Metabolism 299, no. 6 (December 2010): E868-E878. (Review) Full Text
  - Gingras, A-A, White, PJ, Chouinard, PY, Julien, P, Davis, TA, Dombrowski, L, Couture, Y, Dubreuil, P, Myre, A, Bergeron, K, Marette, A, and Thivierge, MC. "Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity." The Journal of Physiology 579, no. Pt 1 (February 2007): 269-284. Full Text
  - White, PJ, and Marette, A. "Is omega-3 key to unlocking inflammation in obesity?." Diabetologia 49, no. 9 (September 2006): 1999-2001. Full Text

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Education, Training, & Certifications

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles