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Micro-CT imaging of multiple K-edge elements using GaAs and CdTe photon counting detectors.

Publication ,  Journal Article
Allphin, AJ; Clark, DP; Thuering, T; Bhandari, P; Ghaghada, KB; Badea, CT
Published in: Phys Med Biol
April 12, 2023

Objective.To evaluate the performance of two photon-counting (PC) detectors based on different detector materials, gallium arsenide (GaAs) and cadmium telluride (CdTe), for PC micro-CT imaging of phantoms with multiple contrast materials. Another objective is to determine if combining these two detectors in the same micro-CT system can offer higher spectral performance and significant artifact reduction compared to a single detector system.Approach. We have constructed a dual-detector, micro-CT system equipped with two PCDs based on different detector materials: gallium arsenide (GaAs) and cadmium telluride (CdTe). We demonstrate the performance of these detectors for PC micro-CT imaging of phantoms with up to 5 contrast materials with K-edges spread across the x-ray spectrum ranging from iodine with a K-edge at 33.2 keV to bismuth with a K-edge at 90.5 keV. We also demonstrate the use of our system to image a mouse prepared with both iodine and bismuth contrast agents to target different biological systems.Main results.When using the same dose and scan parameters, GaAs shows increased low energy (<50 keV) spectral sensitivity and specificity compared to CdTe. However, GaAs performance at high energies suffers from spectral artifacts and has comparatively low photon counts indicating wasted radiation dose. We demonstrate that combining a GaAs-based and a CdTe-based PC detector in the same micro-CT system offers higher spectral performance and significant artifact reduction compared to a single detector system.Significance.More accurate PC micro-CT using a GaAs PCD alone or in combination with a CdTe PCD could serve for developing new contrast agents such as nanoparticles that show promise in the developing field of theranostics (therapy and diagnostics).

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Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

April 12, 2023

Volume

68

Issue

8

Location

England

Related Subject Headings

  • X-Ray Microtomography
  • Tellurium
  • Quantum Dots
  • Nuclear Medicine & Medical Imaging
  • Mice
  • Iodine
  • Contrast Media
  • Cadmium Compounds
  • Bismuth
  • Animals
 

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Allphin, A. J., Clark, D. P., Thuering, T., Bhandari, P., Ghaghada, K. B., & Badea, C. T. (2023). Micro-CT imaging of multiple K-edge elements using GaAs and CdTe photon counting detectors. Phys Med Biol, 68(8). https://doi.org/10.1088/1361-6560/acc77e
Allphin, A. J., D. P. Clark, T. Thuering, P. Bhandari, K. B. Ghaghada, and C. T. Badea. “Micro-CT imaging of multiple K-edge elements using GaAs and CdTe photon counting detectors.Phys Med Biol 68, no. 8 (April 12, 2023). https://doi.org/10.1088/1361-6560/acc77e.
Allphin AJ, Clark DP, Thuering T, Bhandari P, Ghaghada KB, Badea CT. Micro-CT imaging of multiple K-edge elements using GaAs and CdTe photon counting detectors. Phys Med Biol. 2023 Apr 12;68(8).
Allphin, A. J., et al. “Micro-CT imaging of multiple K-edge elements using GaAs and CdTe photon counting detectors.Phys Med Biol, vol. 68, no. 8, Apr. 2023. Pubmed, doi:10.1088/1361-6560/acc77e.
Allphin AJ, Clark DP, Thuering T, Bhandari P, Ghaghada KB, Badea CT. Micro-CT imaging of multiple K-edge elements using GaAs and CdTe photon counting detectors. Phys Med Biol. 2023 Apr 12;68(8).
Journal cover image

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

April 12, 2023

Volume

68

Issue

8

Location

England

Related Subject Headings

  • X-Ray Microtomography
  • Tellurium
  • Quantum Dots
  • Nuclear Medicine & Medical Imaging
  • Mice
  • Iodine
  • Contrast Media
  • Cadmium Compounds
  • Bismuth
  • Animals