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Acute and chronic glutamate NMDA antagonist treatment attenuates dopamine D1 antagonist-induced reduction of nicotine self-administration in female rats.

Publication ,  Journal Article
Natarajan, S; Abass, G; Kim, L; Wells, C; Rezvani, AH; Levin, ED
Published in: Pharmacol Biochem Behav
January 2024

Multiple interacting neural systems are involved in sustaining nicotine reinforcement. We and others have shown that dopamine D1 receptors and glutamate NMDA receptors both play important roles in nicotine reinforcement. Blockade of D1 receptors with the antagonist SCH-23390 (0.02 mg/kg) both acutely and chronically significantly decreased nicotine self-administration in rats. Blockade of NMDA receptors (10 mg/kg) acutely with memantine significantly increased nicotine self-administration, but chronic blockade of NMDA receptors with memantine significantly decreased nicotine self-administration. The current study examined the interactions of acute and chronic administration of SCH-23390 and memantine on nicotine self-administration in female rats. Replicating earlier studies, acute and chronic SCH-23390 significantly decreased nicotine self-administration and memantine had a biphasic effect with acute administration increasing nicotine self-administration and chronic memantine showed a non-significant trend toward decreasing it. However, chronic interaction study showed that memantine significantly attenuated the decrease in nicotine self-administration caused by chronic SCH-23390. These studies provide important information that memantine attenuates the efficacy of D1 antagonist SCH 23390 in reducing nicotine-self-administration. These two drugs do not appear to have mutually potentiating effects to aid tobacco cessation.

Duke Scholars

Published In

Pharmacol Biochem Behav

DOI

EISSN

1873-5177

Publication Date

January 2024

Volume

234

Start / End Page

173678

Location

United States

Related Subject Headings

  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Dopamine D1
  • Rats, Sprague-Dawley
  • Rats
  • Nicotine
  • Neurology & Neurosurgery
  • N-Methylaspartate
  • Memantine
  • Female
  • Excitatory Amino Acid Antagonists
 

Citation

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Natarajan, S., Abass, G., Kim, L., Wells, C., Rezvani, A. H., & Levin, E. D. (2024). Acute and chronic glutamate NMDA antagonist treatment attenuates dopamine D1 antagonist-induced reduction of nicotine self-administration in female rats. Pharmacol Biochem Behav, 234, 173678. https://doi.org/10.1016/j.pbb.2023.173678
Natarajan, Sarabesh, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, and Edward D. Levin. “Acute and chronic glutamate NMDA antagonist treatment attenuates dopamine D1 antagonist-induced reduction of nicotine self-administration in female rats.Pharmacol Biochem Behav 234 (January 2024): 173678. https://doi.org/10.1016/j.pbb.2023.173678.
Natarajan S, Abass G, Kim L, Wells C, Rezvani AH, Levin ED. Acute and chronic glutamate NMDA antagonist treatment attenuates dopamine D1 antagonist-induced reduction of nicotine self-administration in female rats. Pharmacol Biochem Behav. 2024 Jan;234:173678.
Natarajan, Sarabesh, et al. “Acute and chronic glutamate NMDA antagonist treatment attenuates dopamine D1 antagonist-induced reduction of nicotine self-administration in female rats.Pharmacol Biochem Behav, vol. 234, Jan. 2024, p. 173678. Pubmed, doi:10.1016/j.pbb.2023.173678.
Natarajan S, Abass G, Kim L, Wells C, Rezvani AH, Levin ED. Acute and chronic glutamate NMDA antagonist treatment attenuates dopamine D1 antagonist-induced reduction of nicotine self-administration in female rats. Pharmacol Biochem Behav. 2024 Jan;234:173678.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

EISSN

1873-5177

Publication Date

January 2024

Volume

234

Start / End Page

173678

Location

United States

Related Subject Headings

  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Dopamine D1
  • Rats, Sprague-Dawley
  • Rats
  • Nicotine
  • Neurology & Neurosurgery
  • N-Methylaspartate
  • Memantine
  • Female
  • Excitatory Amino Acid Antagonists