Electroclinical Syndromes: Neonatal Onset
Theneonatal-onset electroclinical syndromes can be categorized as selflimiteddisorders or Early Infantile Developmental and Epileptic Encephalopathies(EIDEE). Self-limited syndromes include Self-Limited Neonatal Epilepsy (SeLNE)and Self-Limited Familial Neonatal Epilepsy (SeLFNE). EIDEE includes twooverlapping variants: Ohtahara syndrome and Early Myoclonic Encephalopathy(EME). Given remarkable advances in genetics that have been applied to neonatalonset and other epilepsies, as well as the increasing use of bedside video-EEGmonitoring and novel imaging techniques, we now recognize an expanding numberof underlying etiologies and characteristics related to neonatal-onset electroclinicalsyndromes. This has also enhanced our understanding of theirpathophysiological mechanisms and prognoses, which is beginning to provideinsight into potential effective therapies, hopefully eventually leading to individualizedprecision therapies based on etiology and pathophysiology.
