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Chronic nicotinic stimulation and blockade effects on working memory.

Publication ,  Journal Article
Levin, ED; Briggs, SJ; Christopher, NC; Rose, JE
Published in: Behav Pharmacol
April 1993

Acute and chronic nicotine treatment has been found to improve learning and memory function in a variety of tasks. In several studies we have found that chronic nicotine infusion improves working memory performance. Replicating these results, the current study showed that chronic nicotine treatment (12mg/kg/day) significantly improved working memory performance in the radial-arm maze. The nicotine effect did not diminish during the 2 weeks following withdrawal. The nicotine-induced improvement was eliminated when the nicotinic antagonist mecamylamine (3mg/kg/day) was given concurrently, suggesting that the nicotine effect was mediated via actions on the nicotinic receptor. Surprisingly, when this chronic dose of mecamylamine was given alone, it caused a transient improvement in choice accuracy during the first week of administration. This improvement subsequently became attenuated and was not evident at all by the third and fourth weeks of administration.

Duke Scholars

Published In

Behav Pharmacol

EISSN

1473-5849

Publication Date

April 1993

Volume

4

Issue

2

Start / End Page

179 / 182

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • 5202 Biological psychology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Levin, E. D., Briggs, S. J., Christopher, N. C., & Rose, J. E. (1993). Chronic nicotinic stimulation and blockade effects on working memory. Behav Pharmacol, 4(2), 179–182.
Levin, E. D., S. J. Briggs, N. C. Christopher, and J. E. Rose. “Chronic nicotinic stimulation and blockade effects on working memory.Behav Pharmacol 4, no. 2 (April 1993): 179–82.
Levin ED, Briggs SJ, Christopher NC, Rose JE. Chronic nicotinic stimulation and blockade effects on working memory. Behav Pharmacol. 1993 Apr;4(2):179–82.
Levin, E. D., et al. “Chronic nicotinic stimulation and blockade effects on working memory.Behav Pharmacol, vol. 4, no. 2, Apr. 1993, pp. 179–82.
Levin ED, Briggs SJ, Christopher NC, Rose JE. Chronic nicotinic stimulation and blockade effects on working memory. Behav Pharmacol. 1993 Apr;4(2):179–182.

Published In

Behav Pharmacol

EISSN

1473-5849

Publication Date

April 1993

Volume

4

Issue

2

Start / End Page

179 / 182

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • 5202 Biological psychology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
  • 1115 Pharmacology and Pharmaceutical Sciences