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Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: an observational study.

Publication ,  Journal Article
Aronow, HD; Topol, EJ; Roe, MT; Houghtaling, PL; Wolski, KE; Lincoff, AM; Harrington, RA; Califf, RM; Ohman, EM; Kleiman, NS; Keltai, M ...
Published in: Lancet
April 7, 2001

BACKGROUND: Lipid-lowering agents are known to reduce long-term mortality in patients with stable coronary disease or significant risk factors. However, the effect of lipid-lowering therapy on short-term mortality immediately after an acute coronary syndrome has not been determined. We did an observational study using data from two randomised trials to investigate this issue. METHODS: We used data from the GUSTO IIb and PURSUIT trials to compare all-cause mortality among patients with acute coronary syndromes who were discharged on lipid-lowering agents (n=3653) with those who were not (n=17,156). A propensity analysis was done to adjust for presumed selection biases in the prescription of lipid-lowering agents. FINDINGS: Lipid-lowering therapy was associated with a smaller proportion of deaths at 30 days (17 [0.5%] vs 179 [1.0%], hazard ratio 0.44 [95% CI 0.27-0.73], p=0.001) and at 6 months (63 [1.7%] vs 605 [3.5%], 0.48 [0.37-0.63], p<0.0001). After adjustment for the propensity to be prescribed lipid-lowering agents and other potential confounders, prescription of a lipid-lowering agent at discharge remained associated with a reduced risk of death at 6 months (0.67 [0.48-0.95], p=0.023). INTERPRETATION: Prescription of a lipid-lowering drug at hospital discharge was independently associated with reduced short-term mortality among patients after an acute coronary syndrome.

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Published In

Lancet

DOI

ISSN

0140-6736

Publication Date

April 7, 2001

Volume

357

Issue

9262

Start / End Page

1063 / 1068

Location

England

Related Subject Headings

  • Thrombolytic Therapy
  • Survival Rate
  • Randomized Controlled Trials as Topic
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Logistic Models
  • Hypolipidemic Agents
  • Hyperlipidemias
  • Humans
 

Citation

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Aronow, H. D., Topol, E. J., Roe, M. T., Houghtaling, P. L., Wolski, K. E., Lincoff, A. M., … Lauer, M. S. (2001). Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: an observational study. Lancet, 357(9262), 1063–1068. https://doi.org/10.1016/S0140-6736(00)04257-4
Aronow, H. D., E. J. Topol, M. T. Roe, P. L. Houghtaling, K. E. Wolski, A. M. Lincoff, R. A. Harrington, et al. “Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: an observational study.Lancet 357, no. 9262 (April 7, 2001): 1063–68. https://doi.org/10.1016/S0140-6736(00)04257-4.
Aronow HD, Topol EJ, Roe MT, Houghtaling PL, Wolski KE, Lincoff AM, et al. Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: an observational study. Lancet. 2001 Apr 7;357(9262):1063–8.
Aronow, H. D., et al. “Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: an observational study.Lancet, vol. 357, no. 9262, Apr. 2001, pp. 1063–68. Pubmed, doi:10.1016/S0140-6736(00)04257-4.
Aronow HD, Topol EJ, Roe MT, Houghtaling PL, Wolski KE, Lincoff AM, Harrington RA, Califf RM, Ohman EM, Kleiman NS, Keltai M, Wilcox RG, Vahanian A, Armstrong PW, Lauer MS. Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: an observational study. Lancet. 2001 Apr 7;357(9262):1063–1068.
Journal cover image

Published In

Lancet

DOI

ISSN

0140-6736

Publication Date

April 7, 2001

Volume

357

Issue

9262

Start / End Page

1063 / 1068

Location

England

Related Subject Headings

  • Thrombolytic Therapy
  • Survival Rate
  • Randomized Controlled Trials as Topic
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Logistic Models
  • Hypolipidemic Agents
  • Hyperlipidemias
  • Humans