Skip to main content
Journal cover image

Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans.

Publication ,  Journal Article
Hulver, MW; Berggren, JR; Carper, MJ; Miyazaki, M; Ntambi, JM; Hoffman, EP; Thyfault, JP; Stevens, R; Dohm, GL; Houmard, JA; Muoio, DM
Published in: Cell Metab
October 2005

Obesity and type 2 diabetes are strongly associated with abnormal lipid metabolism and accumulation of intramyocellular triacylglycerol, but the underlying cause of these perturbations are yet unknown. Herein, we show that the lipogenic gene, stearoyl-CoA desaturase 1 (SCD1), is robustly up-regulated in skeletal muscle from extremely obese humans. High expression and activity of SCD1, an enzyme that catalyzes the synthesis of monounsaturated fatty acids, corresponded with low rates of fatty acid oxidation, increased triacylglycerol synthesis and increased monounsaturation of muscle lipids. Elevated SCD1 expression and abnormal lipid partitioning were retained in primary skeletal myocytes derived from obese compared to lean donors, implying that these traits might be driven by epigenetic and/or heritable mechanisms. Overexpression of human SCD1 in myotubes from lean subjects was sufficient to mimic the obese phenotype. These results suggest that elevated expression of SCD1 in skeletal muscle contributes to abnormal lipid metabolism and progression of obesity.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Metab

DOI

ISSN

1550-4131

Publication Date

October 2005

Volume

2

Issue

4

Start / End Page

251 / 261

Location

United States

Related Subject Headings

  • Transfection
  • Thinness
  • Stearoyl-CoA Desaturase
  • Obesity
  • Muscle, Skeletal
  • Muscle Fibers, Skeletal
  • Microarray Analysis
  • Lipid Metabolism
  • In Vitro Techniques
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hulver, M. W., Berggren, J. R., Carper, M. J., Miyazaki, M., Ntambi, J. M., Hoffman, E. P., … Muoio, D. M. (2005). Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab, 2(4), 251–261. https://doi.org/10.1016/j.cmet.2005.09.002
Hulver, Matthew W., Jason R. Berggren, Michael J. Carper, Makoto Miyazaki, James M. Ntambi, Eric P. Hoffman, John P. Thyfault, et al. “Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans.Cell Metab 2, no. 4 (October 2005): 251–61. https://doi.org/10.1016/j.cmet.2005.09.002.
Hulver MW, Berggren JR, Carper MJ, Miyazaki M, Ntambi JM, Hoffman EP, et al. Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab. 2005 Oct;2(4):251–61.
Hulver, Matthew W., et al. “Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans.Cell Metab, vol. 2, no. 4, Oct. 2005, pp. 251–61. Pubmed, doi:10.1016/j.cmet.2005.09.002.
Hulver MW, Berggren JR, Carper MJ, Miyazaki M, Ntambi JM, Hoffman EP, Thyfault JP, Stevens R, Dohm GL, Houmard JA, Muoio DM. Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab. 2005 Oct;2(4):251–261.
Journal cover image

Published In

Cell Metab

DOI

ISSN

1550-4131

Publication Date

October 2005

Volume

2

Issue

4

Start / End Page

251 / 261

Location

United States

Related Subject Headings

  • Transfection
  • Thinness
  • Stearoyl-CoA Desaturase
  • Obesity
  • Muscle, Skeletal
  • Muscle Fibers, Skeletal
  • Microarray Analysis
  • Lipid Metabolism
  • In Vitro Techniques
  • Humans