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Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney.

Publication ,  Journal Article
Mitnick, PD; Greenberg, A; DeOreo, PB; Weiner, BM; Coffman, TM; Walker, BR; Agus, ZS; Goldfarb, S
Published in: Clin Pharmacol Ther
November 1980

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been found to cause sodium retention and to decrease glomerular filtration rate (GFR). We studied the effects of two such drugs, indomethacin and oxaprozin, a new propionic acid derivative, on renal function of awake, normal human subjects during sustained water diuresis. Although neither drug had a long-term effect on GFR or sodium clearance (CNa), indomethacin (six subjects) but not oxaprozin (seven subjects) transiently reduced GFR and CNa. Given over the short term, oxaprozin caused a reduction in GFR from 113.7 +/- 5.7 to 99.8 +/- 4.7 ml/min (p < 0.01) and CNa from 0.84 +/- 0.07 to 0.61 +/- 0.08 ml/min (p < 0.005). The results were much the same when an additional dose of indomethacin was given to subjects who had been receiving the drug for a week. Inference from clearance data at a time when urinary osmolality (Uosm) remained constant but urine flow per GFR (V/GFR) fell suggests that both drugs stimulated proximal tubular sodium and fluid resorption. Both suppressed renin and aldosterone levels comparably and reduced potassium excretion transiently, but only indomethacin caused a sustained change in serum potassium concentration; serum potassium rose from 4.32 +/- 0.10 to 4.56 +/- 0.11 mEq/l (p < 0.05) after 1 wk. These disparate findings suggest that prostaglandin synthesis inhibition may not be the sole mechanism of action of NSAIDs.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

November 1980

Volume

28

Issue

5

Start / End Page

680 / 689

Location

United States

Related Subject Headings

  • Sodium
  • Renin
  • Prostaglandins
  • Propionates
  • Pharmacology & Pharmacy
  • Oxazoles
  • Oxaprozin
  • Male
  • Kidney Concentrating Ability
  • Kidney
 

Citation

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MLA
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Mitnick, P. D., Greenberg, A., DeOreo, P. B., Weiner, B. M., Coffman, T. M., Walker, B. R., … Goldfarb, S. (1980). Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney. Clin Pharmacol Ther, 28(5), 680–689. https://doi.org/10.1038/clpt.1980.221
Mitnick, P. D., A. Greenberg, P. B. DeOreo, B. M. Weiner, T. M. Coffman, B. R. Walker, Z. S. Agus, and S. Goldfarb. “Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney.Clin Pharmacol Ther 28, no. 5 (November 1980): 680–89. https://doi.org/10.1038/clpt.1980.221.
Mitnick PD, Greenberg A, DeOreo PB, Weiner BM, Coffman TM, Walker BR, et al. Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney. Clin Pharmacol Ther. 1980 Nov;28(5):680–9.
Mitnick, P. D., et al. “Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney.Clin Pharmacol Ther, vol. 28, no. 5, Nov. 1980, pp. 680–89. Pubmed, doi:10.1038/clpt.1980.221.
Mitnick PD, Greenberg A, DeOreo PB, Weiner BM, Coffman TM, Walker BR, Agus ZS, Goldfarb S. Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney. Clin Pharmacol Ther. 1980 Nov;28(5):680–689.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

November 1980

Volume

28

Issue

5

Start / End Page

680 / 689

Location

United States

Related Subject Headings

  • Sodium
  • Renin
  • Prostaglandins
  • Propionates
  • Pharmacology & Pharmacy
  • Oxazoles
  • Oxaprozin
  • Male
  • Kidney Concentrating Ability
  • Kidney