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Review and recent development of angle-resolved low-coherence interferometry for detection of precancerous cells in human esophageal epithelium

Publication ,  Journal Article
Brown, WJ; Pyhtila, JW; Terry, NG; Chalut, KJ; D'Amico, TA; Sporn, TA; Obando, JV; Wax, A
Published in: IEEE Journal on Selected Topics in Quantum Electronics
January 1, 2008

The combination of low-coherence interferometry with angle-resolved light scattering measurements has been shown to be a powerful method for determining the structure of cell nuclei within intact tissue samples. The nuclear morphology data have been used as a biomarker of neoplastic change in a wide range of settings. Here, we review the development of angle-resolved lowcoherence interferometry (a/LCI) for assessing the health status of human esophageal epithelial tissues based on depth-resolved measurements of the morphology of cell nuclei. The design and implementation of clinical instrumentation are reviewed, and results from ex vivo human tissue measurements are presented to validate the capabilities of the technique. In addition to the review of earlier papers, new results are presented, which demonstrate the first application of a portable a/LCI system with a flexible endoscopic probe to assessing depth-resolved nuclear morphology in a clinical setting. High sensitivity for the detection of precancerous tissues is demonstrated. © 2008 IEEE.

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Published In

IEEE Journal on Selected Topics in Quantum Electronics

DOI

ISSN

1077-260X

Publication Date

January 1, 2008

Volume

14

Issue

1

Start / End Page

88 / 96

Related Subject Headings

  • Optoelectronics & Photonics
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4008 Electrical engineering
  • 0906 Electrical and Electronic Engineering
  • 0206 Quantum Physics
  • 0205 Optical Physics
 

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Brown, W. J., Pyhtila, J. W., Terry, N. G., Chalut, K. J., D’Amico, T. A., Sporn, T. A., … Wax, A. (2008). Review and recent development of angle-resolved low-coherence interferometry for detection of precancerous cells in human esophageal epithelium. IEEE Journal on Selected Topics in Quantum Electronics, 14(1), 88–96. https://doi.org/10.1109/JSTQE.2007.913969
Brown, W. J., J. W. Pyhtila, N. G. Terry, K. J. Chalut, T. A. D’Amico, T. A. Sporn, J. V. Obando, and A. Wax. “Review and recent development of angle-resolved low-coherence interferometry for detection of precancerous cells in human esophageal epithelium.” IEEE Journal on Selected Topics in Quantum Electronics 14, no. 1 (January 1, 2008): 88–96. https://doi.org/10.1109/JSTQE.2007.913969.
Brown WJ, Pyhtila JW, Terry NG, Chalut KJ, D’Amico TA, Sporn TA, et al. Review and recent development of angle-resolved low-coherence interferometry for detection of precancerous cells in human esophageal epithelium. IEEE Journal on Selected Topics in Quantum Electronics. 2008 Jan 1;14(1):88–96.
Brown, W. J., et al. “Review and recent development of angle-resolved low-coherence interferometry for detection of precancerous cells in human esophageal epithelium.” IEEE Journal on Selected Topics in Quantum Electronics, vol. 14, no. 1, Jan. 2008, pp. 88–96. Scopus, doi:10.1109/JSTQE.2007.913969.
Brown WJ, Pyhtila JW, Terry NG, Chalut KJ, D’Amico TA, Sporn TA, Obando JV, Wax A. Review and recent development of angle-resolved low-coherence interferometry for detection of precancerous cells in human esophageal epithelium. IEEE Journal on Selected Topics in Quantum Electronics. 2008 Jan 1;14(1):88–96.

Published In

IEEE Journal on Selected Topics in Quantum Electronics

DOI

ISSN

1077-260X

Publication Date

January 1, 2008

Volume

14

Issue

1

Start / End Page

88 / 96

Related Subject Headings

  • Optoelectronics & Photonics
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4008 Electrical engineering
  • 0906 Electrical and Electronic Engineering
  • 0206 Quantum Physics
  • 0205 Optical Physics