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Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.

Publication ,  Journal Article
Selznick, LA; Shamji, MF; Fecci, P; Gromeier, M; Friedman, AH; Sampson, J
Published in: Neurosurg Rev
April 2008

The standard treatment paradigm of surgery, radiation, and chemotherapy for malignant gliomas has only a modest effect on survival. It is well emphasized in the literature that despite aggressive multimodal therapy, most patients survive approximately 1 year after diagnosis, and less than 10% survive beyond 2 years. This dismal prognosis provides the impetus for ongoing investigations in search of improved therapeutics. Standard multimodal therapy has largely reached a plateau in terms of effectiveness, and there is now a growing body of literature on novel molecular approaches for the treatment of malignant gliomas. Gene therapy, oncolytic virotherapy, and immunotherapy are the major investigational approaches that have demonstrated promise in preclinical and early clinical studies. These new molecular technologies each have distinct advantages and limitations, and none has yet demonstrated a significant survival benefit in a phase II or III clinical trial. Molecular approaches may not lead to the discovery of a "magic bullet" for these aggressive tumors, but they may ultimately prove synergistic with more conventional approaches and lead to a broadening of the multimodal approach that is the current standard of care. This review will discuss the scientific background, therapeutic potential, and clinical limitations of these novel strategies with a focus on those that have made it to clinical trials.

Duke Scholars

Published In

Neurosurg Rev

DOI

ISSN

0344-5607

Publication Date

April 2008

Volume

31

Issue

2

Start / End Page

141 / 155

Location

Germany

Related Subject Headings

  • Oncolytic Virotherapy
  • Neurology & Neurosurgery
  • Immunotherapy
  • Humans
  • Glioma
  • Genetic Therapy
  • Cancer Vaccines
  • Brain Neoplasms
  • Animals
  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Selznick, L. A., Shamji, M. F., Fecci, P., Gromeier, M., Friedman, A. H., & Sampson, J. (2008). Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines. Neurosurg Rev, 31(2), 141–155. https://doi.org/10.1007/s10143-008-0121-0
Selznick, Lee A., Mohammed F. Shamji, Peter Fecci, Matthias Gromeier, Allan H. Friedman, and John Sampson. “Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.Neurosurg Rev 31, no. 2 (April 2008): 141–55. https://doi.org/10.1007/s10143-008-0121-0.
Selznick LA, Shamji MF, Fecci P, Gromeier M, Friedman AH, Sampson J. Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines. Neurosurg Rev. 2008 Apr;31(2):141–55.
Selznick, Lee A., et al. “Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.Neurosurg Rev, vol. 31, no. 2, Apr. 2008, pp. 141–55. Pubmed, doi:10.1007/s10143-008-0121-0.
Selznick LA, Shamji MF, Fecci P, Gromeier M, Friedman AH, Sampson J. Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines. Neurosurg Rev. 2008 Apr;31(2):141–155.
Journal cover image

Published In

Neurosurg Rev

DOI

ISSN

0344-5607

Publication Date

April 2008

Volume

31

Issue

2

Start / End Page

141 / 155

Location

Germany

Related Subject Headings

  • Oncolytic Virotherapy
  • Neurology & Neurosurgery
  • Immunotherapy
  • Humans
  • Glioma
  • Genetic Therapy
  • Cancer Vaccines
  • Brain Neoplasms
  • Animals
  • 3209 Neurosciences