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Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration.

Publication ,  Journal Article
Rosenthal, R; Wohlleben, H; Malek, G; Schlichting, L; Thieme, H; Bowes Rickman, C; Strauss, O
Published in: Biochem Biophys Res Commun
October 29, 2004

Choroidal neovascularization (CNV) is a debilitating complication of age-related macular degeneration and a leading cause of vision loss. Along with other angiogenic factors like vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF)-1 and its receptor, IGF-1R, have been implicated in CNV. IGF-1 is produced in neurons and retinal pigment epithelium (RPE) but its targets and impact in CNV are not understood. IGF-1 immunoreactivity was abundant throughout surgically isolated human CNV tissues and RPE cells were immunopositive for IGF-1R. Cultured RPE cells obtained from CNV tissues expressed IGF-1R. IGF-1 stimulation of cultured cells from CNV tissues induced monophasic sustained rises in intracellular free Ca(2+). VEGF concentration in the medium of unstimulated RPE cell cultures from CNV tissues increased with time to a steady-state (8h) which was increased twofold by IGF-1 stimulation. Thus, in RPE cells IGF-1 stimulates the second messenger Ca(2+) and increases VEGF secretion which, in turn, induces neovascularization.

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Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

October 29, 2004

Volume

323

Issue

4

Start / End Page

1203 / 1208

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Tissue Distribution
  • Pigment Epithelium of Eye
  • Middle Aged
  • Male
  • Macular Degeneration
  • Insulin-Like Growth Factor I
  • Humans
  • Female
  • Culture Techniques
 

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Rosenthal, R., Wohlleben, H., Malek, G., Schlichting, L., Thieme, H., Bowes Rickman, C., & Strauss, O. (2004). Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration. Biochem Biophys Res Commun, 323(4), 1203–1208. https://doi.org/10.1016/j.bbrc.2004.08.219
Rosenthal, Rita, Hendrik Wohlleben, Goldis Malek, Lars Schlichting, Hagen Thieme, Catherine Bowes Rickman, and Olaf Strauss. “Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration.Biochem Biophys Res Commun 323, no. 4 (October 29, 2004): 1203–8. https://doi.org/10.1016/j.bbrc.2004.08.219.
Rosenthal R, Wohlleben H, Malek G, Schlichting L, Thieme H, Bowes Rickman C, et al. Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration. Biochem Biophys Res Commun. 2004 Oct 29;323(4):1203–8.
Rosenthal, Rita, et al. “Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration.Biochem Biophys Res Commun, vol. 323, no. 4, Oct. 2004, pp. 1203–08. Pubmed, doi:10.1016/j.bbrc.2004.08.219.
Rosenthal R, Wohlleben H, Malek G, Schlichting L, Thieme H, Bowes Rickman C, Strauss O. Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration. Biochem Biophys Res Commun. 2004 Oct 29;323(4):1203–1208.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

October 29, 2004

Volume

323

Issue

4

Start / End Page

1203 / 1208

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Tissue Distribution
  • Pigment Epithelium of Eye
  • Middle Aged
  • Male
  • Macular Degeneration
  • Insulin-Like Growth Factor I
  • Humans
  • Female
  • Culture Techniques