Arthritis syndromes associated with human T cell lymphotropic virus type I infection.

Arthritis syndromes occur associated with HTLV-I infection both in the presence and in the absence of clinical ATL, and polyarthritis may be the presenting manifestation of HTLV-I-associated ATL. In both clinical settings, HTLV-I-infected T cells home to affected joints, and tax-transgenic mouse studies have suggested a pathogenic role for the HTLV-I tax gene in inducing synovial cell proliferation in HAA. Understanding the pathogenesis of rheumatoid arthritis-like arthritis syndromes that occur in the setting of HTLV-I infection should also provide insights into understanding of cellular and molecular mechanisms of synovial cell proliferation in HTLV-I-negative rheumatoid arthritis.

Duke Scholars

Author Rex Monroe McCallum Medicine, Rheumatology and Immunology

Author Dhavalkumar Dhirajlal Patel Medicine, Rheumatology and Immunology

Author Joseph Odell Moore Medicine, Hematological Malignancies

Author Barton Ford Haynes Medicine, Duke Human Vaccine Institute