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Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.

Publication ,  Journal Article
Li, JH; Lao, XQ; Tillmann, HL; Rowell, J; Patel, K; Thompson, A; Suchindran, S; Muir, AJ; Guyton, JR; Gardner, SD; McHutchison, JG; McCarthy, JJ
Published in: Hepatology
June 2010

UNLABELLED: Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda gene region were associated with response to IFN-based treatment of hepatitis C infection. Both infection with the hepatitis C virus and IFN therapy are associated with decreased serum cholesterol and high cholesterol has been associated with increased likelihood to respond to IFN. We sought to determine if the IFN-lambda gene variant was also associated with serum lipid levels in chronic hepatitis C patients. We compared genotypes of the rs12979860 polymorphism, located proximal to the IL28 gene, with serum lipid and apolipoprotein levels in 746 subjects with chronic hepatitis C virus infection, not currently undergoing treatment, using multivariable analysis of variance. Levels of total cholesterol (P = 6.0 x 10(-4)), apolipoprotein B (P = 1.3 x 10(-6)) and low-density lipoprotein (LDL) cholesterol (P = 8.9 x 10(-10)) were significantly higher in subjects carrying the rs12979860 CC responder genotype compared with those with the CT or TT genotype. Levels of triglycerides (P = 0.03), apolipoprotein A-I (P = 0.06), and apolipoprotein E (P = 0.01) were slightly lower in the rs12979860 CC genotype group, whereas levels of high-density lipoprotein cholesterol (P = 0.78) and apolipoprotein C-III (P = 0.74) did not vary by rs12979860 genotype. CONCLUSION: Our results suggest that low levels of LDL cholesterol in chronic hepatitis C patients may be a marker of host endogenous IFN response to hepatitis C and that subjects with the rs12979860 CC responder genotype may have a lower endogenous IFN response to the virus.

Duke Scholars

Published In

Hepatology

DOI

EISSN

1527-3350

Publication Date

June 2010

Volume

51

Issue

6

Start / End Page

1904 / 1911

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Interleukins
  • Interferons
  • Humans
  • Hepatitis C, Chronic
  • Genotype
  • Genetic Association Studies
  • Gastroenterology & Hepatology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, J. H., Lao, X. Q., Tillmann, H. L., Rowell, J., Patel, K., Thompson, A., … McCarthy, J. J. (2010). Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection. Hepatology, 51(6), 1904–1911. https://doi.org/10.1002/hep.23592
Li, Josephine H., Xiang Qian Lao, Hans L. Tillmann, Jennifer Rowell, Keyur Patel, Alexander Thompson, Sunil Suchindran, et al. “Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.Hepatology 51, no. 6 (June 2010): 1904–11. https://doi.org/10.1002/hep.23592.
Li JH, Lao XQ, Tillmann HL, Rowell J, Patel K, Thompson A, et al. Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection. Hepatology. 2010 Jun;51(6):1904–11.
Li, Josephine H., et al. “Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.Hepatology, vol. 51, no. 6, June 2010, pp. 1904–11. Pubmed, doi:10.1002/hep.23592.
Li JH, Lao XQ, Tillmann HL, Rowell J, Patel K, Thompson A, Suchindran S, Muir AJ, Guyton JR, Gardner SD, McHutchison JG, McCarthy JJ. Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection. Hepatology. 2010 Jun;51(6):1904–1911.
Journal cover image

Published In

Hepatology

DOI

EISSN

1527-3350

Publication Date

June 2010

Volume

51

Issue

6

Start / End Page

1904 / 1911

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Interleukins
  • Interferons
  • Humans
  • Hepatitis C, Chronic
  • Genotype
  • Genetic Association Studies
  • Gastroenterology & Hepatology