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John Richard Guyton

Professor Emeritus of Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
Duke Box 3510, Durham, NC 27710
281 Baker House, Brown Zone-Duke South, Durham, NC 27710


Current research efforts focus on the role of niacin in clinical lipid practice. Despite the ending of a large clinical trial due to lack of benefit, niacin remains the second best lipid-modifying drug after statins. Why this trial did not replicate earlier success with niacin is a matter of great interest. Counterregulatory hormone responses may provide the answer. Another research focus is weight loss counseling in the busy clinic setting. Low glycemic dietary advice achieved average long-term weight loss of 3% (beyond 1 year) in a recently published study. One in four patients had long-term weight loss greater than 6%.

Dr. Guyton is recognized nationally as an expert in clinical management of lipid disorders and a leader in postgraduate education in this area. Both nationally and internationally, Dr. Guyton is known for his earlier work on lipid deposition in the arterial wall.

Key words: atherosclerosis, lipoproteins, statins, niacin, triglycerides, low density lipoproteins, high density lipoproteins

Current Appointments & Affiliations

Professor Emeritus of Medicine · 2023 - Present Medicine, Endocrinology, Metabolism, and Nutrition, Medicine

Education, Training & Certifications

Harvard University · 1973 M.D.
University of Mississippi · 1969 B.S.