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Nitric oxide and redox mechanisms in the immune response.

Publication ,  Journal Article
Wink, DA; Hines, HB; Cheng, RYS; Switzer, CH; Flores-Santana, W; Vitek, MP; Ridnour, LA; Colton, CA
Published in: J Leukoc Biol
June 2011

The role of redox molecules, such as NO and ROS, as key mediators of immunity has recently garnered renewed interest and appreciation. To regulate immune responses, these species trigger the eradication of pathogens on the one hand and modulate immunosuppression during tissue-restoration and wound-healing processes on the other. In the acidic environment of the phagosome, a variety of RNS and ROS is produced, thereby providing a cauldron of redox chemistry, which is the first line in fighting infection. Interestingly, fluctuations in the levels of these same reactive intermediates orchestrate other phases of the immune response. NO activates specific signal transduction pathways in tumor cells, endothelial cells, and monocytes in a concentration-dependent manner. As ROS can react directly with NO-forming RNS, NO bioavailability and therefore, NO response(s) are changed. The NO/ROS balance is also important during Th1 to Th2 transition. In this review, we discuss the chemistry of NO and ROS in the context of antipathogen activity and immune regulation and also discuss similarities and differences between murine and human production of these intermediates.

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Published In

J Leukoc Biol

DOI

EISSN

1938-3673

Publication Date

June 2011

Volume

89

Issue

6

Start / End Page

873 / 891

Location

England

Related Subject Headings

  • Signal Transduction
  • Oxidation-Reduction
  • Nitric Oxide
  • Immunology
  • Immunity, Cellular
  • Humans
  • Animals
  • 3204 Immunology
  • 1107 Immunology
  • 0601 Biochemistry and Cell Biology
 

Citation

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Chicago
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Wink, D. A., Hines, H. B., Cheng, R. Y. S., Switzer, C. H., Flores-Santana, W., Vitek, M. P., … Colton, C. A. (2011). Nitric oxide and redox mechanisms in the immune response. J Leukoc Biol, 89(6), 873–891. https://doi.org/10.1189/jlb.1010550
Wink, David A., Harry B. Hines, Robert Y. S. Cheng, Christopher H. Switzer, Wilmarie Flores-Santana, Michael P. Vitek, Lisa A. Ridnour, and Carol A. Colton. “Nitric oxide and redox mechanisms in the immune response.J Leukoc Biol 89, no. 6 (June 2011): 873–91. https://doi.org/10.1189/jlb.1010550.
Wink DA, Hines HB, Cheng RYS, Switzer CH, Flores-Santana W, Vitek MP, et al. Nitric oxide and redox mechanisms in the immune response. J Leukoc Biol. 2011 Jun;89(6):873–91.
Wink, David A., et al. “Nitric oxide and redox mechanisms in the immune response.J Leukoc Biol, vol. 89, no. 6, June 2011, pp. 873–91. Pubmed, doi:10.1189/jlb.1010550.
Wink DA, Hines HB, Cheng RYS, Switzer CH, Flores-Santana W, Vitek MP, Ridnour LA, Colton CA. Nitric oxide and redox mechanisms in the immune response. J Leukoc Biol. 2011 Jun;89(6):873–891.

Published In

J Leukoc Biol

DOI

EISSN

1938-3673

Publication Date

June 2011

Volume

89

Issue

6

Start / End Page

873 / 891

Location

England

Related Subject Headings

  • Signal Transduction
  • Oxidation-Reduction
  • Nitric Oxide
  • Immunology
  • Immunity, Cellular
  • Humans
  • Animals
  • 3204 Immunology
  • 1107 Immunology
  • 0601 Biochemistry and Cell Biology