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Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results.

Publication ,  Journal Article
McAdams, HP; Palmer, SM; Donnelly, LF; Charles, HC; Tapson, VF; MacFall, JR
Published in: AJR Am J Roentgenol
October 1999

OBJECTIVE: Bronchiolitis obliterans syndrome is the major cause of long-term graft failure in lung transplant recipients and may be partially reversible if diagnosed early and treated. Diagnosis is difficult because findings of transbronchial biopsy are often negative in patients with early disease. We are investigating a novel MR ventilation agent, hyperpolarized 3He, for evaluating ventilatory abnormalities in lung transplant recipients with suspected bronchiolitis obliterans syndrome. CONCLUSION: In this preliminary study, the extent of ventilatory defects revealed on 3He-enhanced MR images correlated with severity of bronchiolitis obliterans syndrome using an established clinical grading system. This new technique may hold potential for diagnosing bronchiolitis obliterans syndrome in lung transplant recipients.

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Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

October 1999

Volume

173

Issue

4

Start / End Page

955 / 959

Location

United States

Related Subject Headings

  • Postoperative Complications
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Lung Transplantation
  • Lung
  • Isotopes
  • Humans
  • Helium
 

Citation

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McAdams, H. P., Palmer, S. M., Donnelly, L. F., Charles, H. C., Tapson, V. F., & MacFall, J. R. (1999). Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results. AJR Am J Roentgenol, 173(4), 955–959. https://doi.org/10.2214/ajr.173.4.10511156
McAdams, H. P., S. M. Palmer, L. F. Donnelly, H. C. Charles, V. F. Tapson, and J. R. MacFall. “Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results.AJR Am J Roentgenol 173, no. 4 (October 1999): 955–59. https://doi.org/10.2214/ajr.173.4.10511156.
McAdams HP, Palmer SM, Donnelly LF, Charles HC, Tapson VF, MacFall JR. Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results. AJR Am J Roentgenol. 1999 Oct;173(4):955–9.
McAdams, H. P., et al. “Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results.AJR Am J Roentgenol, vol. 173, no. 4, Oct. 1999, pp. 955–59. Pubmed, doi:10.2214/ajr.173.4.10511156.
McAdams HP, Palmer SM, Donnelly LF, Charles HC, Tapson VF, MacFall JR. Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results. AJR Am J Roentgenol. 1999 Oct;173(4):955–959.

Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

October 1999

Volume

173

Issue

4

Start / End Page

955 / 959

Location

United States

Related Subject Headings

  • Postoperative Complications
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Lung Transplantation
  • Lung
  • Isotopes
  • Humans
  • Helium