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Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up.

Publication ,  Journal Article
Fowler, VG; Sanders, LL; Kong, LK; McClelland, RS; Gottlieb, GS; Li, J; Ryan, T; Sexton, DJ; Roussakis, G; Harrell, LJ; Corey, GR
Published in: Clin Infect Dis
January 1999

Fifty-nine consecutive patients with definite Staphylococcus aureus infective endocarditis (IE) by the Duke criteria were prospectively identified at our hospital over a 3-year period. Twenty-seven (45.8%) of the 59 patients had hospital-acquired S. aureus bacteremia. The presumed source of infection was an intravascular device in 50.8% of patients. Transthoracic echocardiography (TTE) revealed evidence of IE in 20 patients (33.9%), whereas transesophageal echocardiography (TEE) revealed evidence of IE in 48 patients (81.4%). The outcome for patients was strongly associated with echocardiographic findings: 13 (68.4%) of 19 patients with vegetations visualized by TTE had an embolic event or died of their infection vs. five (16.7%) of 30 patients whose vegetations were visualized only by TEE (P < .01). Most patients with S. aureus IE developed their infection as a consequence of a nosocomial or intravascular device-related infection. TEE established the diagnosis of S. aureus IE in many instances when TTE was nondiagnostic. Visualization of vegetations by TTE may provide prognostic information for patients with S. aureus IE.

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Published In

Clin Infect Dis

DOI

ISSN

1058-4838

Publication Date

January 1999

Volume

28

Issue

1

Start / End Page

106 / 114

Location

United States

Related Subject Headings

  • Vancomycin
  • Treatment Outcome
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prospective Studies
  • Middle Aged
  • Microbiology
  • Male
  • Lactams
  • Humans
 

Citation

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Fowler, V. G., Sanders, L. L., Kong, L. K., McClelland, R. S., Gottlieb, G. S., Li, J., … Corey, G. R. (1999). Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up. Clin Infect Dis, 28(1), 106–114. https://doi.org/10.1086/515076
Fowler, V. G., L. L. Sanders, L. K. Kong, R. S. McClelland, G. S. Gottlieb, J. Li, T. Ryan, et al. “Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up.Clin Infect Dis 28, no. 1 (January 1999): 106–14. https://doi.org/10.1086/515076.
Fowler VG, Sanders LL, Kong LK, McClelland RS, Gottlieb GS, Li J, et al. Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up. Clin Infect Dis. 1999 Jan;28(1):106–14.
Fowler, V. G., et al. “Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up.Clin Infect Dis, vol. 28, no. 1, Jan. 1999, pp. 106–14. Pubmed, doi:10.1086/515076.
Fowler VG, Sanders LL, Kong LK, McClelland RS, Gottlieb GS, Li J, Ryan T, Sexton DJ, Roussakis G, Harrell LJ, Corey GR. Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up. Clin Infect Dis. 1999 Jan;28(1):106–114.

Published In

Clin Infect Dis

DOI

ISSN

1058-4838

Publication Date

January 1999

Volume

28

Issue

1

Start / End Page

106 / 114

Location

United States

Related Subject Headings

  • Vancomycin
  • Treatment Outcome
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prospective Studies
  • Middle Aged
  • Microbiology
  • Male
  • Lactams
  • Humans