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Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study.

Publication ,  Journal Article
Madden, DJ; Spaniol, J; Whiting, WL; Bucur, B; Provenzale, JM; Cabeza, R; White, LE; Huettel, SA
Published in: Neurobiol Aging
March 2007

We combined measures from event-related functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), and cognitive performance (visual search response time) to test the hypotheses that differences between younger and older adults in top-down (goal-directed) attention would be related to cortical activation, and that white matter integrity as measured by DTI (fractional anisotropy, FA) would be a mediator of this age-related effect. Activation in frontal and parietal cortical regions was overall greater for older adults than for younger adults. The relation between activation and search performance supported the hypothesis of age differences in top-down attention. When the task involved top-down control (increased target predictability), performance was associated with frontoparietal activation for older adults, but with occipital (fusiform) activation for younger adults. White matter integrity (FA) exhibited an age-related decline that was more pronounced for anterior brain regions than for posterior regions, but white matter integrity did not specifically mediate the age-related increase in activation of the frontoparietal attentional network.

Duke Scholars

Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

March 2007

Volume

28

Issue

3

Start / End Page

459 / 476

Location

United States

Related Subject Headings

  • Visual Perception
  • Visual Cortex
  • Statistics as Topic
  • Reaction Time
  • Photic Stimulation
  • Oxygen
  • Neurology & Neurosurgery
  • Multivariate Analysis
  • Male
  • Magnetic Resonance Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Madden, D. J., Spaniol, J., Whiting, W. L., Bucur, B., Provenzale, J. M., Cabeza, R., … Huettel, S. A. (2007). Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study. Neurobiol Aging, 28(3), 459–476. https://doi.org/10.1016/j.neurobiolaging.2006.01.005
Madden, David J., Julia Spaniol, Wythe L. Whiting, Barbara Bucur, James M. Provenzale, Roberto Cabeza, Leonard E. White, and Scott A. Huettel. “Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study.Neurobiol Aging 28, no. 3 (March 2007): 459–76. https://doi.org/10.1016/j.neurobiolaging.2006.01.005.
Madden DJ, Spaniol J, Whiting WL, Bucur B, Provenzale JM, Cabeza R, et al. Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study. Neurobiol Aging. 2007 Mar;28(3):459–76.
Madden, David J., et al. “Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study.Neurobiol Aging, vol. 28, no. 3, Mar. 2007, pp. 459–76. Pubmed, doi:10.1016/j.neurobiolaging.2006.01.005.
Madden DJ, Spaniol J, Whiting WL, Bucur B, Provenzale JM, Cabeza R, White LE, Huettel SA. Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study. Neurobiol Aging. 2007 Mar;28(3):459–476.
Journal cover image

Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

March 2007

Volume

28

Issue

3

Start / End Page

459 / 476

Location

United States

Related Subject Headings

  • Visual Perception
  • Visual Cortex
  • Statistics as Topic
  • Reaction Time
  • Photic Stimulation
  • Oxygen
  • Neurology & Neurosurgery
  • Multivariate Analysis
  • Male
  • Magnetic Resonance Imaging