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Age-related slowing of memory retrieval: contributions of perceptual speed and cerebral white matter integrity.

Publication ,  Journal Article
Bucur, B; Madden, DJ; Spaniol, J; Provenzale, JM; Cabeza, R; White, LE; Huettel, SA
Published in: Neurobiol Aging
July 2008

Previous research suggests that, in reaction time (RT) measures of episodic memory retrieval, the unique effects of adult age are relatively small compared to the effects aging shares with more elementary abilities such as perceptual speed. Little is known, however, regarding the mechanisms of perceptual speed. We used diffusion tensor imaging (DTI) to test the hypothesis that white matter integrity, as indexed by fractional anisotropy (FA), serves as one mechanism of perceptual slowing in episodic memory retrieval. Results indicated that declines in FA in the pericallosal frontal region and in the genu of the corpus callosum, but not in other regions, mediated the relationship between perceptual speed and episodic retrieval RT. This relation held, though to a different degree, for both hits and correct rejections. These findings suggest that white matter integrity in prefrontal regions is one mechanism underlying the relation between individual differences in perceptual speed and episodic retrieval.

Duke Scholars

Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

July 2008

Volume

29

Issue

7

Start / End Page

1070 / 1079

Location

United States

Related Subject Headings

  • Task Performance and Analysis
  • Speech Perception
  • Reaction Time
  • Neurology & Neurosurgery
  • Nerve Fibers, Myelinated
  • Middle Aged
  • Mental Recall
  • Male
  • Humans
  • Female
 

Citation

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ICMJE
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Bucur, B., Madden, D. J., Spaniol, J., Provenzale, J. M., Cabeza, R., White, L. E., & Huettel, S. A. (2008). Age-related slowing of memory retrieval: contributions of perceptual speed and cerebral white matter integrity. Neurobiol Aging, 29(7), 1070–1079. https://doi.org/10.1016/j.neurobiolaging.2007.02.008
Bucur, Barbara, David J. Madden, Julia Spaniol, James M. Provenzale, Roberto Cabeza, Leonard E. White, and Scott A. Huettel. “Age-related slowing of memory retrieval: contributions of perceptual speed and cerebral white matter integrity.Neurobiol Aging 29, no. 7 (July 2008): 1070–79. https://doi.org/10.1016/j.neurobiolaging.2007.02.008.
Bucur B, Madden DJ, Spaniol J, Provenzale JM, Cabeza R, White LE, et al. Age-related slowing of memory retrieval: contributions of perceptual speed and cerebral white matter integrity. Neurobiol Aging. 2008 Jul;29(7):1070–9.
Bucur, Barbara, et al. “Age-related slowing of memory retrieval: contributions of perceptual speed and cerebral white matter integrity.Neurobiol Aging, vol. 29, no. 7, July 2008, pp. 1070–79. Pubmed, doi:10.1016/j.neurobiolaging.2007.02.008.
Bucur B, Madden DJ, Spaniol J, Provenzale JM, Cabeza R, White LE, Huettel SA. Age-related slowing of memory retrieval: contributions of perceptual speed and cerebral white matter integrity. Neurobiol Aging. 2008 Jul;29(7):1070–1079.
Journal cover image

Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

July 2008

Volume

29

Issue

7

Start / End Page

1070 / 1079

Location

United States

Related Subject Headings

  • Task Performance and Analysis
  • Speech Perception
  • Reaction Time
  • Neurology & Neurosurgery
  • Nerve Fibers, Myelinated
  • Middle Aged
  • Mental Recall
  • Male
  • Humans
  • Female