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Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions.

Publication ,  Journal Article
Wang, Z; Wu, QJ; Marks, LB; Larrier, N; Yin, F-F
Published in: Int J Radiat Oncol Biol Phys
December 1, 2007

PURPOSE: In this study, we investigate a technique of matching internal target volumes (ITVs) in four-dimensional (4D) simulation computed tomography (CT) to the composite target volume in free-breathing on-board cone-beam (CB) CT. The technique is illustrated by using both phantom and patient cases. METHODS AND MATERIALS: A dynamic phantom with a target ball simulating respiratory motion with various amplitude and cycle times was used to verify localization accuracy. The dynamic phantom was scanned using simulation CT with a phase-based retrospective sorting technique. The ITV was then determined based on 10 sets of sorted images. The size and epicenter of the ITV identified from 4D simulation CT images and the composite target volume identified from on-board CBCT images were compared to assess localization accuracy. Similarly, for two clinical cases of patients with lung cancer, ITVs defined from 4D simulation CT images and CBCT images were compared. RESULTS: For the phantom, localization accuracy between the ITV in 4D simulation CT and the composite target volume in CBCT was within 1 mm, and ITV was within 8.7%. For patient cases, ITVs on simulation CT and CBCT were within 8.0%. CONCLUSION: This study shows that CBCT is a useful tool to localize ITV for targets affected by respiratory motion. Verification of the ITV from 4D simulation CT using on-board free-breathing CBCT is feasible for the target localization of lung tumors.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

December 1, 2007

Volume

69

Issue

5

Start / End Page

1618 / 1624

Location

United States

Related Subject Headings

  • Tumor Burden
  • Stereotaxic Techniques
  • Respiration
  • Phantoms, Imaging
  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Humans
  • Cone-Beam Computed Tomography
  • 5105 Medical and biological physics
  • 3407 Theoretical and computational chemistry
 

Citation

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ICMJE
MLA
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Wang, Z., Wu, Q. J., Marks, L. B., Larrier, N., & Yin, F.-F. (2007). Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions. Int J Radiat Oncol Biol Phys, 69(5), 1618–1624. https://doi.org/10.1016/j.ijrobp.2007.08.030
Wang, Zhiheng, Q Jackie Wu, Lawrence B. Marks, Nicole Larrier, and Fang-Fang Yin. “Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions.Int J Radiat Oncol Biol Phys 69, no. 5 (December 1, 2007): 1618–24. https://doi.org/10.1016/j.ijrobp.2007.08.030.
Wang Z, Wu QJ, Marks LB, Larrier N, Yin F-F. Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions. Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1618–24.
Wang, Zhiheng, et al. “Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions.Int J Radiat Oncol Biol Phys, vol. 69, no. 5, Dec. 2007, pp. 1618–24. Pubmed, doi:10.1016/j.ijrobp.2007.08.030.
Wang Z, Wu QJ, Marks LB, Larrier N, Yin F-F. Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions. Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1618–1624.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

December 1, 2007

Volume

69

Issue

5

Start / End Page

1618 / 1624

Location

United States

Related Subject Headings

  • Tumor Burden
  • Stereotaxic Techniques
  • Respiration
  • Phantoms, Imaging
  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Humans
  • Cone-Beam Computed Tomography
  • 5105 Medical and biological physics
  • 3407 Theoretical and computational chemistry