Skip to main content
Journal cover image

Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins

Publication ,  Journal Article
Hoffman, AS; Stayton, PS; Shimoboji, T; Chen, G; Ding, Z; Chilkoti, A; Long, C; Miura, M; Chen, J; Park, T; Monji, N; Cole, CA; Harris, JM; Nakamae, K
Published in: Macromolecular Symposia
January 1, 1997

Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1-4) This presentation reviews the principles, methodolgies and applications of these "smart" polymer-biomolecule systems, with special focus on temperature-sensitive polymer-protein conjugates.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Macromolecular Symposia

DOI

ISSN

1022-1360

Publication Date

January 1, 1997

Volume

118

Start / End Page

553 / 562

Related Subject Headings

  • 3403 Macromolecular and materials chemistry
  • 0303 Macromolecular and Materials Chemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hoffman, A. S., Stayton, P. S., Shimoboji, T., Chen, G., Ding, Z., Chilkoti, A., … Nakamae, K. (1997). Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins. Macromolecular Symposia, 118, 553–562. https://doi.org/10.1002/masy.19971180173
Hoffman, A. S., P. S. Stayton, T. Shimoboji, G. Chen, Z. Ding, A. Chilkoti, C. Long, et al. “Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins.” Macromolecular Symposia 118 (January 1, 1997): 553–62. https://doi.org/10.1002/masy.19971180173.
Hoffman AS, Stayton PS, Shimoboji T, Chen G, Ding Z, Chilkoti A, et al. Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins. Macromolecular Symposia. 1997 Jan 1;118:553–62.
Hoffman, A. S., et al. “Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins.” Macromolecular Symposia, vol. 118, Jan. 1997, pp. 553–62. Scopus, doi:10.1002/masy.19971180173.
Hoffman AS, Stayton PS, Shimoboji T, Chen G, Ding Z, Chilkoti A, Long C, Miura M, Chen J, Park T, Monji N, Cole CA, Harris JM, Nakamae K. Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins. Macromolecular Symposia. 1997 Jan 1;118:553–562.
Journal cover image

Published In

Macromolecular Symposia

DOI

ISSN

1022-1360

Publication Date

January 1, 1997

Volume

118

Start / End Page

553 / 562

Related Subject Headings

  • 3403 Macromolecular and materials chemistry
  • 0303 Macromolecular and Materials Chemistry