Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins
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, Journal Article
Hoffman, AS; Stayton, PS; Shimoboji, T; Chen, G; Ding, Z; Chilkoti, A; Long, C; Miura, M; Chen, J; Park, T; Monji, N; Cole, CA; Harris, JM; Nakamae, K
Published in: Macromolecular Symposia
January 1, 1997
Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1-4) This presentation reviews the principles, methodolgies and applications of these "smart" polymer-biomolecule systems, with special focus on temperature-sensitive polymer-protein conjugates.
Duke Scholars
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Published In
Macromolecular Symposia
DOI
ISSN
1022-1360
Publication Date
January 1, 1997
Volume
118
Start / End Page
553 / 562
Related Subject Headings
- 3403 Macromolecular and materials chemistry
- 0303 Macromolecular and Materials Chemistry
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Hoffman, A. S., Stayton, P. S., Shimoboji, T., Chen, G., Ding, Z., Chilkoti, A., … Nakamae, K. (1997). Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins. Macromolecular Symposia, 118, 553–562. https://doi.org/10.1002/masy.19971180173
Hoffman, A. S., P. S. Stayton, T. Shimoboji, G. Chen, Z. Ding, A. Chilkoti, C. Long, et al. “Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins.” Macromolecular Symposia 118 (January 1, 1997): 553–62. https://doi.org/10.1002/masy.19971180173.
Hoffman AS, Stayton PS, Shimoboji T, Chen G, Ding Z, Chilkoti A, et al. Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins. Macromolecular Symposia. 1997 Jan 1;118:553–62.
Hoffman, A. S., et al. “Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins.” Macromolecular Symposia, vol. 118, Jan. 1997, pp. 553–62. Scopus, doi:10.1002/masy.19971180173.
Hoffman AS, Stayton PS, Shimoboji T, Chen G, Ding Z, Chilkoti A, Long C, Miura M, Chen J, Park T, Monji N, Cole CA, Harris JM, Nakamae K. Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins. Macromolecular Symposia. 1997 Jan 1;118:553–562.
Published In
Macromolecular Symposia
DOI
ISSN
1022-1360
Publication Date
January 1, 1997
Volume
118
Start / End Page
553 / 562
Related Subject Headings
- 3403 Macromolecular and materials chemistry
- 0303 Macromolecular and Materials Chemistry