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Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ.

Publication ,  Journal Article
Liu, W; McDaniel, J; Li, X; Asai, D; Quiroz, FG; Schaal, J; Park, JS; Zalutsky, M; Chilkoti, A
Published in: Cancer Res
November 15, 2012

Brachytherapy is a common clinical technique involving implantation of sealed radioactive "seeds" within a tumor to selectively irradiate the tumor mass while minimizing systemic toxicity. To mitigate the disadvantages associated with complex surgical implantation and subsequent device removal procedures, we have developed an alternative approach using a genetically encoded peptide polymer solution composed of a thermally responsive elastin-like polypeptide (ELP) radiolabeled with (131)I that self-assembles into radionuclide seeds upon intratumoral injection. The formation of these nontoxic and biodegradable polymer seeds led to prolonged intratumoral retention (~85% ID/tumor 7 days postinjection) of the radionuclide, elicited a tumor growth delay in 100% of the tumors in two human xenografts (FaDu and PC-3), and cured more than 67% of tumor-bearing animals after a single administration of labeled ELP. These results suggest that in situ self-assembly of biodegradable and injectable radionuclide-containing polypeptide seeds could be a promising therapeutic alternative to conventional brachytherapy.

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Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

November 15, 2012

Volume

72

Issue

22

Start / End Page

5956 / 5965

Location

United States

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Tandem Repeat Sequences
  • Prostatic Neoplasms
  • Peptides
  • Oncology & Carcinogenesis
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Iodine Radioisotopes
 

Citation

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Liu, W., McDaniel, J., Li, X., Asai, D., Quiroz, F. G., Schaal, J., … Chilkoti, A. (2012). Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ. Cancer Res, 72(22), 5956–5965. https://doi.org/10.1158/0008-5472.CAN-12-2127
Liu, Wenge, Jonathan McDaniel, Xinghai Li, Daisuke Asai, Felipe Garcia Quiroz, Jeffery Schaal, Ji Sun Park, Michael Zalutsky, and Ashutosh Chilkoti. “Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ.Cancer Res 72, no. 22 (November 15, 2012): 5956–65. https://doi.org/10.1158/0008-5472.CAN-12-2127.
Liu W, McDaniel J, Li X, Asai D, Quiroz FG, Schaal J, et al. Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ. Cancer Res. 2012 Nov 15;72(22):5956–65.
Liu, Wenge, et al. “Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ.Cancer Res, vol. 72, no. 22, Nov. 2012, pp. 5956–65. Pubmed, doi:10.1158/0008-5472.CAN-12-2127.
Liu W, McDaniel J, Li X, Asai D, Quiroz FG, Schaal J, Park JS, Zalutsky M, Chilkoti A. Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ. Cancer Res. 2012 Nov 15;72(22):5956–5965.

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

November 15, 2012

Volume

72

Issue

22

Start / End Page

5956 / 5965

Location

United States

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Tandem Repeat Sequences
  • Prostatic Neoplasms
  • Peptides
  • Oncology & Carcinogenesis
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Iodine Radioisotopes