Skip to main content
Journal cover image

Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.

Publication ,  Journal Article
Callahan, DJ; Liu, W; Li, X; Dreher, MR; Hassouneh, W; Kim, M; Marszalek, P; Chilkoti, A
Published in: Nano letters
April 2012

To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nano letters

DOI

EISSN

1530-6992

ISSN

1530-6984

Publication Date

April 2012

Volume

12

Issue

4

Start / End Page

2165 / 2170

Related Subject Headings

  • Peptides
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Micelles
  • Hydrogen-Ion Concentration
  • Histidine
  • Drug Carriers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Callahan, D. J., Liu, W., Li, X., Dreher, M. R., Hassouneh, W., Kim, M., … Chilkoti, A. (2012). Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution. Nano Letters, 12(4), 2165–2170. https://doi.org/10.1021/nl300630c
Callahan, Daniel J., Wenge Liu, Xinghai Li, Matthew R. Dreher, Wafa Hassouneh, Minkyu Kim, Piotr Marszalek, and Ashutosh Chilkoti. “Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.Nano Letters 12, no. 4 (April 2012): 2165–70. https://doi.org/10.1021/nl300630c.
Callahan DJ, Liu W, Li X, Dreher MR, Hassouneh W, Kim M, et al. Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution. Nano letters. 2012 Apr;12(4):2165–70.
Callahan, Daniel J., et al. “Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.Nano Letters, vol. 12, no. 4, Apr. 2012, pp. 2165–70. Epmc, doi:10.1021/nl300630c.
Callahan DJ, Liu W, Li X, Dreher MR, Hassouneh W, Kim M, Marszalek P, Chilkoti A. Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution. Nano letters. 2012 Apr;12(4):2165–2170.
Journal cover image

Published In

Nano letters

DOI

EISSN

1530-6992

ISSN

1530-6984

Publication Date

April 2012

Volume

12

Issue

4

Start / End Page

2165 / 2170

Related Subject Headings

  • Peptides
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Micelles
  • Hydrogen-Ion Concentration
  • Histidine
  • Drug Carriers