Skip to main content
Journal cover image

Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies.

Publication ,  Journal Article
Newgard, CB; Hohmeier, HE; Lu, D; Jensen, MV; Tran, VV; Chen, G; Burgess, S; Sherry, AD
Published in: Cell Biochem Biophys
2004

Type 1 and type 2 diabetes are both diseases of insulin insufficiency, although they develop by distinct pathways. The recent surge in the incidence of type 2 diabetes and the chronic ailments confronted by patients with either form of the disease highlight the need for better understanding of beta-cell biology. In this review, we present recent work focused on this goal. Our hope is that basic research being conducted in this and other laboratories will ultimately contribute to the development of methods for enhancing beta-cell function and survival in the context of both major forms of diabetes. Our strategy for understanding the beta-cell involves a multidisciplinary approach in which tools from the traditional fields of biochemistry, enzymology, and physiology are teamed with newer technologies from the fields of molecular biology, gene discovery, cell and developmental biology, and biophysical chemistry. We have focused on two important aspects of beta-cell biology in our studies: beta-cell function, specifically the metabolic regulatory mechanisms involved in glucose-stimulated insulin secretion, and beta-cell resistance to immune attack, with emphasis on resistance to inflammatory cytokines and reactive oxygen species.

Duke Scholars

Published In

Cell Biochem Biophys

DOI

EISSN

1559-0283

Publication Date

2004

Volume

40

Issue

3 Suppl

Start / End Page

159 / 168

Location

United States

Related Subject Headings

  • Reactive Oxygen Species
  • Pyruvic Acid
  • Models, Genetic
  • Magnetic Resonance Spectroscopy
  • Interleukin-1beta
  • Insulin-Secreting Cells
  • Insulin Secretion
  • Insulin
  • Inflammation
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Newgard, C. B., Hohmeier, H. E., Lu, D., Jensen, M. V., Tran, V. V., Chen, G., … Sherry, A. D. (2004). Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies. Cell Biochem Biophys, 40(3 Suppl), 159–168. https://doi.org/10.1385/cbb:40:3:159
Newgard, Christopher B., Hans E. Hohmeier, Danhong Lu, Mette Valentin Jensen, Veronique V. Tran, Guoxun Chen, Shawn Burgess, and A Dean Sherry. “Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies.Cell Biochem Biophys 40, no. 3 Suppl (2004): 159–68. https://doi.org/10.1385/cbb:40:3:159.
Newgard CB, Hohmeier HE, Lu D, Jensen MV, Tran VV, Chen G, et al. Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies. Cell Biochem Biophys. 2004;40(3 Suppl):159–68.
Newgard, Christopher B., et al. “Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies.Cell Biochem Biophys, vol. 40, no. 3 Suppl, 2004, pp. 159–68. Pubmed, doi:10.1385/cbb:40:3:159.
Newgard CB, Hohmeier HE, Lu D, Jensen MV, Tran VV, Chen G, Burgess S, Sherry AD. Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies. Cell Biochem Biophys. 2004;40(3 Suppl):159–168.
Journal cover image

Published In

Cell Biochem Biophys

DOI

EISSN

1559-0283

Publication Date

2004

Volume

40

Issue

3 Suppl

Start / End Page

159 / 168

Location

United States

Related Subject Headings

  • Reactive Oxygen Species
  • Pyruvic Acid
  • Models, Genetic
  • Magnetic Resonance Spectroscopy
  • Interleukin-1beta
  • Insulin-Secreting Cells
  • Insulin Secretion
  • Insulin
  • Inflammation
  • Humans