Reducing systemic toxicity in local tumor gene therapy using an alginate solution
Publication
, Journal Article
Wang, Y; Hu, JK; Krol, A; Li, YP; Li, CY; Yuan, F
Published in: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
December 1, 2002
To reduce dissemination of viral vectors and their gene products during and after local gene therapy, we mixed adenoviral vectors with an alginate solution and subsequently injected the mixture into mouse tumors. We found that the alginate solution significantly reduced the dissemination of adenoviral vectors for EGFP and IL-12 into the liver and the IL-12 concentration in the serum. On the other hand, the alginate solution had no effects on EGFP and IL-12 expressions in tumors as well as the growth of IL-12 vector treated tumors.
Duke Scholars
Published In
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN
0589-1019
Publication Date
December 1, 2002
Volume
1
Start / End Page
565
Citation
APA
Chicago
ICMJE
MLA
NLM
Wang, Y., Hu, J. K., Krol, A., Li, Y. P., Li, C. Y., & Yuan, F. (2002). Reducing systemic toxicity in local tumor gene therapy using an alginate solution. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 1, 565.
Wang, Y., J. K. Hu, A. Krol, Y. P. Li, C. Y. Li, and F. Yuan. “Reducing systemic toxicity in local tumor gene therapy using an alginate solution.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 1 (December 1, 2002): 565.
Wang Y, Hu JK, Krol A, Li YP, Li CY, Yuan F. Reducing systemic toxicity in local tumor gene therapy using an alginate solution. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2002 Dec 1;1:565.
Wang, Y., et al. “Reducing systemic toxicity in local tumor gene therapy using an alginate solution.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 1, Dec. 2002, p. 565.
Wang Y, Hu JK, Krol A, Li YP, Li CY, Yuan F. Reducing systemic toxicity in local tumor gene therapy using an alginate solution. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2002 Dec 1;1:565.
Published In
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN
0589-1019
Publication Date
December 1, 2002
Volume
1
Start / End Page
565