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Method of lesioning brainstem determines seizure probability.

Publication ,  Journal Article
Silver, JM; Bonhaus, DW; McNamara, JO
Published in: J Neurosci Methods
September 1986

We examined 3 different methods of brainstem lesioning to assess their propensities to evoke seizures in the early postoperative period. Lesioning by electrolysis or microinjection of the neurotoxin, N-methyl-D,L-aspartate, caused seizures, but lesioning by thermocoagulation (radiofrequency current) did not. In paradigms in which postoperative lesion-induced seizures could confound interpretation of experimental results, the thermocoagulative method offers an important advantage.

Duke Scholars

Published In

J Neurosci Methods

DOI

ISSN

0165-0270

Publication Date

September 1986

Volume

17

Issue

4

Start / End Page

303 / 310

Location

Netherlands

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Neurology
  • N-Methylaspartate
  • Male
  • Hot Temperature
  • Electric Injuries
  • Brain Stem
 

Citation

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Silver, J. M., Bonhaus, D. W., & McNamara, J. O. (1986). Method of lesioning brainstem determines seizure probability. J Neurosci Methods, 17(4), 303–310. https://doi.org/10.1016/0165-0270(86)90131-7
Silver, J. M., D. W. Bonhaus, and J. O. McNamara. “Method of lesioning brainstem determines seizure probability.J Neurosci Methods 17, no. 4 (September 1986): 303–10. https://doi.org/10.1016/0165-0270(86)90131-7.
Silver JM, Bonhaus DW, McNamara JO. Method of lesioning brainstem determines seizure probability. J Neurosci Methods. 1986 Sep;17(4):303–10.
Silver, J. M., et al. “Method of lesioning brainstem determines seizure probability.J Neurosci Methods, vol. 17, no. 4, Sept. 1986, pp. 303–10. Pubmed, doi:10.1016/0165-0270(86)90131-7.
Silver JM, Bonhaus DW, McNamara JO. Method of lesioning brainstem determines seizure probability. J Neurosci Methods. 1986 Sep;17(4):303–310.
Journal cover image

Published In

J Neurosci Methods

DOI

ISSN

0165-0270

Publication Date

September 1986

Volume

17

Issue

4

Start / End Page

303 / 310

Location

Netherlands

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Neurology
  • N-Methylaspartate
  • Male
  • Hot Temperature
  • Electric Injuries
  • Brain Stem