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Disc formation in cholesterol-free liposomes during phase transition.

Publication ,  Journal Article
Ickenstein, LM; Arfvidsson, MC; Needham, D; Mayer, LD; Edwards, K
Published in: Biochimica et biophysica acta
August 2003

Cryogenic transmission electron microscopy (cryo-TEM) images of lysolipid-containing thermosensitive liposomes (LTSL) revealed that open liposomes and bilayer discs appeared when liposomes were cycled through the gel (Lbeta') to liquid-crystalline (Lalpha) phase transition. The amount of bilayer discs generated was dependent on the combined presence of PEG-lipid and lysolipid in the membrane. We hypothesize that micelle-forming membrane components stabilize the rim of bilayer openings and membrane discs that form when liposomes are cycled through TC.

Duke Scholars

Published In

Biochimica et biophysica acta

DOI

EISSN

1878-2434

ISSN

0006-3002

Publication Date

August 2003

Volume

1614

Issue

2

Start / End Page

135 / 138

Related Subject Headings

  • Temperature
  • Polyethylene Glycols
  • Phase Transition
  • Micelles
  • Liposomes
  • Lipid Bilayers
  • Cryoelectron Microscopy
  • 51 Physical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ickenstein, L. M., Arfvidsson, M. C., Needham, D., Mayer, L. D., & Edwards, K. (2003). Disc formation in cholesterol-free liposomes during phase transition. Biochimica et Biophysica Acta, 1614(2), 135–138. https://doi.org/10.1016/s0005-2736(03)00196-2
Ickenstein, Ludger M., Maria C. Arfvidsson, David Needham, Lawrence D. Mayer, and Katarina Edwards. “Disc formation in cholesterol-free liposomes during phase transition.Biochimica et Biophysica Acta 1614, no. 2 (August 2003): 135–38. https://doi.org/10.1016/s0005-2736(03)00196-2.
Ickenstein LM, Arfvidsson MC, Needham D, Mayer LD, Edwards K. Disc formation in cholesterol-free liposomes during phase transition. Biochimica et biophysica acta. 2003 Aug;1614(2):135–8.
Ickenstein, Ludger M., et al. “Disc formation in cholesterol-free liposomes during phase transition.Biochimica et Biophysica Acta, vol. 1614, no. 2, Aug. 2003, pp. 135–38. Epmc, doi:10.1016/s0005-2736(03)00196-2.
Ickenstein LM, Arfvidsson MC, Needham D, Mayer LD, Edwards K. Disc formation in cholesterol-free liposomes during phase transition. Biochimica et biophysica acta. 2003 Aug;1614(2):135–138.

Published In

Biochimica et biophysica acta

DOI

EISSN

1878-2434

ISSN

0006-3002

Publication Date

August 2003

Volume

1614

Issue

2

Start / End Page

135 / 138

Related Subject Headings

  • Temperature
  • Polyethylene Glycols
  • Phase Transition
  • Micelles
  • Liposomes
  • Lipid Bilayers
  • Cryoelectron Microscopy
  • 51 Physical sciences
  • 31 Biological sciences
  • 06 Biological Sciences