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Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo.

Publication ,  Journal Article
Zalutsky, M; Magistretti, P; Gallagher, P; Ghidoni, R
Published in: Pharmacol Res Commun
October 1985

Ganglioside GM1 was labeled with 125I either directly or after conjugation to tyramine. Direct iodination of the sphingosine chain resulted in a compound which dehalogenated rapidly both in vitro and in vivo. The binding of the 125I[GM1-tyramine] conjugate to neuronal membranes in vitro was similar to that reported for 3H-GM1. The biodistribution of 125I activity after intravenous injection of 0.5 uM and 5 uM 125I[GM1-tyramine] in mice was also similar to that reported for 3H-GM1. This radioiodinated GM1 derivative might be useful for the study of ganglioside GM1 function in vivo.

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Published In

Pharmacol Res Commun

DOI

ISSN

0031-6989

Publication Date

October 1985

Volume

17

Issue

10

Start / End Page

897 / 912

Location

United States

Related Subject Headings

  • Tissue Distribution
  • Time Factors
  • Rats, Inbred Strains
  • Rats
  • Neurons
  • Micelles
  • Male
  • Iodine Radioisotopes
  • G(M1) Ganglioside
  • Animals
 

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Zalutsky, M., Magistretti, P., Gallagher, P., & Ghidoni, R. (1985). Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo. Pharmacol Res Commun, 17(10), 897–912. https://doi.org/10.1016/0031-6989(85)90032-3
Zalutsky, M., P. Magistretti, P. Gallagher, and R. Ghidoni. “Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo.Pharmacol Res Commun 17, no. 10 (October 1985): 897–912. https://doi.org/10.1016/0031-6989(85)90032-3.
Zalutsky M, Magistretti P, Gallagher P, Ghidoni R. Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo. Pharmacol Res Commun. 1985 Oct;17(10):897–912.
Zalutsky, M., et al. “Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo.Pharmacol Res Commun, vol. 17, no. 10, Oct. 1985, pp. 897–912. Pubmed, doi:10.1016/0031-6989(85)90032-3.
Zalutsky M, Magistretti P, Gallagher P, Ghidoni R. Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo. Pharmacol Res Commun. 1985 Oct;17(10):897–912.

Published In

Pharmacol Res Commun

DOI

ISSN

0031-6989

Publication Date

October 1985

Volume

17

Issue

10

Start / End Page

897 / 912

Location

United States

Related Subject Headings

  • Tissue Distribution
  • Time Factors
  • Rats, Inbred Strains
  • Rats
  • Neurons
  • Micelles
  • Male
  • Iodine Radioisotopes
  • G(M1) Ganglioside
  • Animals