Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo.
Publication
, Journal Article
Zalutsky, M; Magistretti, P; Gallagher, P; Ghidoni, R
Published in: Pharmacol Res Commun
October 1985
Ganglioside GM1 was labeled with 125I either directly or after conjugation to tyramine. Direct iodination of the sphingosine chain resulted in a compound which dehalogenated rapidly both in vitro and in vivo. The binding of the 125I[GM1-tyramine] conjugate to neuronal membranes in vitro was similar to that reported for 3H-GM1. The biodistribution of 125I activity after intravenous injection of 0.5 uM and 5 uM 125I[GM1-tyramine] in mice was also similar to that reported for 3H-GM1. This radioiodinated GM1 derivative might be useful for the study of ganglioside GM1 function in vivo.
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Published In
Pharmacol Res Commun
DOI
ISSN
0031-6989
Publication Date
October 1985
Volume
17
Issue
10
Start / End Page
897 / 912
Location
United States
Related Subject Headings
- Tissue Distribution
- Time Factors
- Rats, Inbred Strains
- Rats
- Neurons
- Micelles
- Male
- Iodine Radioisotopes
- G(M1) Ganglioside
- Animals
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Zalutsky, M., Magistretti, P., Gallagher, P., & Ghidoni, R. (1985). Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo. Pharmacol Res Commun, 17(10), 897–912. https://doi.org/10.1016/0031-6989(85)90032-3
Zalutsky, M., P. Magistretti, P. Gallagher, and R. Ghidoni. “Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo.” Pharmacol Res Commun 17, no. 10 (October 1985): 897–912. https://doi.org/10.1016/0031-6989(85)90032-3.
Zalutsky M, Magistretti P, Gallagher P, Ghidoni R. Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo. Pharmacol Res Commun. 1985 Oct;17(10):897–912.
Zalutsky, M., et al. “Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo.” Pharmacol Res Commun, vol. 17, no. 10, Oct. 1985, pp. 897–912. Pubmed, doi:10.1016/0031-6989(85)90032-3.
Zalutsky M, Magistretti P, Gallagher P, Ghidoni R. Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo. Pharmacol Res Commun. 1985 Oct;17(10):897–912.
Published In
Pharmacol Res Commun
DOI
ISSN
0031-6989
Publication Date
October 1985
Volume
17
Issue
10
Start / End Page
897 / 912
Location
United States
Related Subject Headings
- Tissue Distribution
- Time Factors
- Rats, Inbred Strains
- Rats
- Neurons
- Micelles
- Male
- Iodine Radioisotopes
- G(M1) Ganglioside
- Animals